A normal spring morning cascades into a nightmare world for Mera Stevens as 1.8 billion children simultaneously fall ill and then vanish from the face of the earth. Her son, Jeremy, is one of them. Increased natural disasters, onslaught of disease and other phenomena throws the world into chaos as it balances on the brink of extinction. With communications down, Mera gathers the courage and strength she needs to trek across a dying country in search of a daughter she desperately hopes is alive.

Since childhood Nila Carter has been made to spend every weekend at the family cabin. In her teenage years she believes it to be a prison; as an adult it becomes her sanctuary and means to survive. When a mysterious outbreak occurs in India, Nila's brother, Bobby, a virologist with the CDC, places the family on a precautionary alert to be ready to bug out. Unlike anything he's ever seen, the rabies-like virus is not just deadly; it causes extreme violent behavior in those infected.

One of the greatest threats to mankind's existence has become a reality. The Yellowstone Caldera erupts with a force of a thousand nuclear warheads, expelling seven hundred cubic miles of ash and rock all at once into the sky. And it's not finished . . .

It happens on a routine red-eye from Las Vegas to New York. Just as the plane breaks the early morning sky, in a blink of an eye, 144 passengers onboard flight 6520 die. There is no rhyme or reason. Experts scramble to find an explanation on how and why those on Flight 6520 met their demise so quickly and violently. It is hurriedly explained as a terror attack to the public, but General Buford Cane knows better. He has spent his entire career dedicated to the investigation and prevention of globe-threatening events.

After emerging from a coma, Faye Wills opens her eyes to complete darkness and the feeling of being trapped. Soon she discovers she is in no less than a nightmare world and awakens in the worst place imaginable. She is one of thousands of bodies in a makeshift mass grave that was once a football stadium. Left for dead. There are no signs of life and the only sound she hears is the buzzing of flies that follow the stench of death.

After the killing of a prominent mob lawyer, NYPD homicide detectives Jacob Jackson and Caitlin Grimes start receive chilling, written “rules” for how to commit the perfect murder. "Rule number one for the perfect murder: Evidence is your enemy. Leave none behind." Jackson (Reid Scott) and Grimes (Cobie Smulders) race to find the killer, setting them on a collision course with the city’s crime underbelly, and a perpetrator who seems happy to toy with them. “Rule number two. No crimes of passion. The perfect murder is always business, never pleasure.”

Kidnappers grabbed Jenna in broad daylight, right in front of her children and their horrified classmates. Her family was issued an insane ransom demand: $25 million in cash and jewels, payable by the end of the school day, otherwise they’ll never see her again. As Jenna’s mother scrambles to gather the money, detectives Mo Butler and George Ortega follow the trail of the kidnappers, which will lead them through a sordid landscape of jealous lovers, broken dreamers, and twisted schemers. But every second counts, and there’s one thing Jenna Wade doesn’t have: very much time.

When Heather McKinley dreamed of becoming a doctor, she imagined curing sick kids and sporting pink stethoscopes. She never anticipated the sleepless nights, grueling exams, and endless labs. And she certainly never knew that her medical school earned the nickname Dead Med thanks to the tragic history of students overdosing on illegal drugs. But Heather would never consider doing anything like that. That is, until her longtime boyfriend dumps her, she finds herself failing anatomy, and her world starts to crumble.

Lowen Ashleigh is a struggling writer on the brink of financial ruin when she accepts the job offer of a lifetime. Jeremy Crawford, husband of best-selling author Verity Crawford, has hired Lowen to complete the remaining books in a successful series his injured wife is unable to finish. Lowen arrives at the Crawford home, ready to sort through years of Verity's notes and outlines, hoping to find enough material to get her started. What Lowen doesn't expect to uncover in the chaotic office is an unfinished autobiography Verity never intended for anyone to read.

Cassie thinks she has met the perfect man. Joel is sweet, handsome, romantic, and best of all, he’s crazy about Cassie. She thinks she’s found the guy she’ll spend the rest of her life with. Have children with. Grow old with. Yes, she knows about his perfect ex-girlfriend, Francesca. The beautiful, brilliant chef, beloved by all his friends. But she thinks Francesca is out of the picture. She thinks Francesca is gone for good. Think again, Cassie.

Jazz Bashara is a criminal. Well, sort of. Life on Artemis, the first and only city on the moon, is tough if you're not a rich tourist or an eccentric billionaire. So smuggling in the occasional harmless bit of contraband barely counts, right? Not when you've got debts to pay and your job as a porter barely covers the rent. Everything changes when Jazz sees the chance to commit the perfect crime, with a reward too lucrative to turn down.

Sloan will go through hell and back for those she loves. And she does so, every single day. Caught up with the alluring Asa Jackson, a notorious drug trafficker, Sloan has finally found a lifeline to cling to, even if it’s meant compromising her morals. She was in dire straits trying to pay for her brother’s care until she met Asa. But as Sloan became emotionally and economically reliant on him, he in turn developed a disturbing obsession with her—one that becomes increasingly dangerous every day.

Jenny sits in the same seat on the same train every week, seeing familiar faces come and go. Until a chance encounter shatters her world. Sixteen years ago, Jenny survived a traumatic ordeal that left her best friend, Susie, missing and presumed dead. The world has its theories about what happened to Susie Patterson, and one of those theories points the finger at Jenny. Now she lives a quiet life, volunteering at a crisis helpline while trying to deal with her own anxiety and the true crime fans obsessed with finding her missing friend.

They were madly in love. The perfect couple. That was the story everyone in South River believed...until Gin Talcott and Adam Archer are found shot in their bed. Adam is dead at the scene. Gin is fighting for her life. Detectives Greta Jessup and Finn Pate are assigned to the case. Greta has a long history with Gin’s first husband, Eddie, and is determined to protect his 18-year-old twins. Piper discovered the bodies. Daniel is missing—and so is Adam’s gun.

As Charly struggles to recover from her brain injury, she begins to realize that the events of that fateful night are trapped in the damaged right side of her brain. Now, she must put the jigsaw pieces together to discover the identity of the man who tried to kill her...before he finishes the job he started.