Featuring a slide presentation and related discussion from Dr Surbhi Sidana, including the following topics:

• Key clinical data of FDA-approved chimeric antigen receptor (CAR) T-cell therapies (0:00)
• Real-world evidence evaluating utility of CAR T-cell therapies in the clinic (8:08)
• Impact of prior BCMA-targeted treatment on CAR T-cell therapy efficacy (12:55)
• Investigational CAR T-cell therapies in clinical development (15:08)
• Incidence and management of toxicities associated with CAR T-cell therapy (18:21)

CME information and select publications

Featuring slide presentations and related discussion from Dr Joyce O'Shaughnessy, Dr Mark Pegram and Prof Peter Schmid, including the following topics:

• Strategies to Identify Patients with HER2-Low and HER2-Ultralow Breast Cancer (0:00)
• Case: A woman in her mid 50s initially presenting with ER-positive, HER2 IHC 1+ locally advanced breast cancer who experiences progression to HER2 0 metastatic disease (20:53)
• Case: A woman in her early 60s with ER-positive, HER2 IHC 1+ metastatic breast cancer (mBC) who experiences disease progression 8 months after starting first-line CDK4/6 and aromatase inhibitor (29:14)
• Expanding the Spectrum of Targeted Therapy (38:52)
• Case: A woman in her early 60s with HR-positive, HER2 IHC 1+ mBC who receives fifth-line T-DXd resulting in stable disease (1:04:13)
• Case: A woman in her early 50s with progressive HR-positive, HER2 IHC 0 mBC and an ESR1 mutation who has ultralow HER2 expression on rebiopsy of new liver lesions (1:12:35)
• Identification and Management of Adverse Events with T-DXd (1:20:27)
• Case: A woman in her late 40s with HR-positive, HER2 IHC 2+ mBC who experienced persistent low-grade nausea with T-DXd that resolved with olanzapine (1:34:02)
• Case: A woman in her early 60s with ER-positive, HER2 2+ mBC who received T-DXd resulting in fatigue and asymptomatic interstitial lung disease (1:48:58)

CME information and select publications

Featuring perspectives from Dr Anthony El-Khoueiry, Dr Richard S Finn, Dr Aiwu Ruth He and Dr Stacey Stein, moderated by Dr Stephen “Fred” Divers, including the following topics:

• Adjuvant Systemic Therapy for Early-Stage Hepatocellular Carcinoma (HCC) — Dr El-Khoueiry
  • Introduction (0:00)
  • Faculty Presentation (3:08)
  • IMbrave050: Adjuvant systemic treatment for high-risk resected HCC — Robin K (Katie) Kelley, MD and Thomas A Abrams, MD (13:43)
  • Neoadjuvant systemic therapy for patients with borderline resectable HCC — Dr Abrams (20:15)
  • Case: A man in his early 70s with locally advanced HCC and tumor thrombus that extends into the right atrium — Ghassan Abou-Alfa, MD, MBA (24:34)
• Recent Developments in the Management of Intermediate-Stage HCC — Dr Finn
  • Faculty Presentation (31:18)
  • EMERALD-1 and LEAP-012 trials of TACE with immunotherapy — Drs Abrams and Kelley (42:15)
  • Systemic treatment for patients with Child-Pugh B cirrhosis and HCC — Dr Kelley (48:29)
  • Use of immunotherapy for patients with autoimmune disorders: A man in his early 30s with active colitis and metastatic HCC receives first-line lenvatinib — Drs Abrams and Abou-Alfa (53:05)
• Current First-Line Therapy for Advanced HCC — Dr He
  • Faculty Presentation (1:00:39)
  • Selection of first-line treatment regimen for advanced HCC — Drs Abrams, Kelley and Abou-Alfa (1:12:00)
  • Role of single-agent immunotherapy in the treatment of advanced HCC — Dr Kelley (1:18:22)
  • Management of HCC in patients with discordant tumor markers or mixed tumor histology — Dr Abrams (1:23:03)
• Promising Investigational Front-Line Strategies for Advanced HCC; Selection and Sequencing of Therapy for Relapsed/Refractory HCC — Dr Stein
  • Faculty Presentation (1:29:42)
  • Choice of tyrosine kinase inhibitor as second-line systemic treatment for HCC; prevention, monitoring and mitigation of lenvatinib-associated side effects — Dr Kelley (1:42:59)
  • Case: A man in his early 70s with metastatic HCC that has rapidly progressed on atezolizumab/bevacizumab — Dr Abou-Alfa (1:49:27)
  • Supportive care measures to manage ascites in patients with HCC — Dr Abrams (1:55:20)

CME information and select publications

Featuring perspectives from Dr Enriqueta Felip and Dr Helena Yu, including the following topics:

• Introduction (0:00)
• First-Line Treatment of Metastatic Disease (2:34)
• Adjuvant and Neoadjuvant Therapy (22:31)
• EGFR Exon 20 Insertion Mutations (34:21)
• Antibody-Drug Conjugates (42:45)

CME information and select publications

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in EGFR-Mutant Non-Small Cell Lung Cancer | Faculty Presentation 2: Other Relevant Topics in EGFR Mutation-Positive NSCLC, Such as Nonmetastatic Disease, Exon 20 Insertion Mutations and Novel Agents — Helena Yu, MD

CME information and select publications

Featuring an interview with Dr Seth Wander, including the following topics:

• Therapy selection after CDK4/6 inhibitor failure: A review of current and investigational treatment for HR-positive, HER2-negative breast cancer
  • Astore S et al. A therapeutic algorithm guiding subsequent therapy selection after CDK4/6 inhibitors’ failure: A review of current and investigational treatment for HR+/Her2- breast cancer. Crit Rev Oncol Hematol 2024;204:104535. Abstract (0:00)
• A preoperative window-of-opportunity study of the oral SERD imlunestrant for newly diagnosed ER-positive, HER2-negative localized breast cancer
  • Neven P et al. A preoperative window-of-opportunity study of oral SERD, imlunestrant, in newly diagnosed ER-positive, HER2-negative early breast cancer: Results from the EMBER-2 Study. Clin Cancer Res 2024;30(23):5304-13. Abstract (3:30)
• An assessment of an exosome-based ESR1-monitoring RT-qPCR kit that detects acquired resistance variants in liquid biopsy samples
  • Statt S et al. An exosome-based ESR1 monitoring RT-qPCR kit that rapidly and accurately detects acquired resistance variants at ≤ 0.1% frequency in liquid biopsy samples. ESMO 2024;Abstract 420P. (7:08)

CME information and select publications

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in EGFR-Mutant Non-Small Cell Lung Cancer | Faculty Presentation 1: Management of Metastatic EGFR Mutation-Positive NSCLC — Enriqueta Felip, MD, PhD

CME information and select publications

Featuring an interview with Dr Saad Zafar Usmani, including the following topics:

• Optimizing treatment intervention for patients with newly diagnosed multiple myeloma (MM) (0:00)
• Role of anti-CD38 antibodies in induction and maintenance therapy for patients with newly diagnosed disease (4:22)
• Case: A woman in her late 70s with revised International Staging System (R-ISS) Stage II IgG kappa myeloma who received D-Rd followed by maintenance daratumumab (14:02)
• Case: A man in his early 60s with double-hit myeloma who received D-KRd and carfilzomib maintenance therapy (26:10)
• Case: A man in his early 70s with R-ISS Stage III IgG kappa myeloma and translocation (4;14) who deferred transplant (33:24)
• Future directions in the management of MM (40:37)

CME information and select publications