In this episode of the JACC: Asia podcast, Editor-in-Chief Jian'an Wang provides a concise summary of the November 2024 issue, featuring five impactful studies on cardiovascular and metabolic health in Asian populations. Highlights include research on patient mismatch after aortic valve replacement, outcomes of mitral valve repair, and genetic links between lipid levels and type 2 diabetes risk, underscoring the importance of personalized healthcare approaches for Asian patients.

In this episode of the JACC: Asia podcast, Cheol Hyun Lee explores the prognostic impact of patient-prosthesis mismatch (PPM) following transcatheter aortic valve replacement (TAVR) in Asian patients, who tend to have smaller annular sizes compared to Western populations. The study highlights that while severe PPM occurs in only 1.3% of patients, it is significantly linked to a higher risk of heart failure hospitalization, underscoring the need for personalized treatment approaches in Asia to reduce the risk of severe PPM.

In this episode of the JACC: Asia podcast, Professor Hao-Min Cheng discusses a study on the association between pre-pregnancy cardiometabolic factors and the risk of gestational diabetes among Asian populations in the U.S., revealing that higher BMI and hypertension significantly increase the risk. The study also highlights that Asian Americans, despite having lower rates of obesity and hypertension, face a notably higher prevalence of gestational diabetes, emphasizing the need for further research on body fat distribution and early glucose screening to better manage this risk.

In this episode of the JACC: Asia podcast, Editor-in-Chief Jian'an Wang examines the EXPAND G4 study and evaluates the one-year outcomes of the first-generation Edge-to-Edge mitral valve repair device in 95 Japanese patients, demonstrating a 100% implantation success rate and significant improvements in mitral regurgitation severity and functional capacity. These promising results underscore the potential of this device to deliver excellent clinical outcomes for Asian patients with mitral valve disease.

In this episode of the JACC: Asia podcast, Editor-in-Chief Jian'an Wang examines the link between pre-pregnancy cardiometabolic factors, such as BMI and hypertension, and the risk of gestational diabetes among Asian populations in the United States. The findings highlight the elevated prevalence of gestational diabetes in these groups and stress the need for early screening and intervention to improve outcomes for high-risk patients.

In this episode of the JACC: Asia podcast, Editor-in-Chief Jian'an Wang examines a large-scale study revealing that early ablation for atrial fibrillation significantly reduces the risk of arrhythmia recurrence in heart failure patients, compared to delayed ablation. While timing of the procedure didn't affect mortality or heart failure hospitalization rates, these findings emphasize the importance of timely intervention for better long-term outcomes in this patient group.

In this episode of the JACC: Asia podcast, Editor-in-Chief Jian'an Wang examines a study which explores the genetic links between lipid levels and type 2 diabetes risk in the Chinese population, using data from the Quinson community cohort. The findings suggest that lower genetic risk scores for LDL-C and triglycerides are associated with a higher risk of diabetes, highlighting the need for personalized lipid management strategies, especially in light of the potential risks of long-term APOC inhibitor use.

In this podcast, Editor-in-Chief Jian'an Wang discusses the ongoing debate over patient-prosthesis mismatch (PPM) following transcatheter aortic valve replacement (TAVR), highlighting conflicting findings between Western and Asian cohorts. Recent data from the updated Ocean TAVR registry suggests that severe PPM is an independent risk factor for long-term mortality and rehospitalization, underscoring the need for personalized device selection to improve outcomes, particularly in patients with smaller annuli and larger body surface areas.