![Valley of Forgetting Audiobook By Jennie Erin Smith cover art](https://m.media-amazon.com/images/I/514vW-MAXkL._SL500_.jpg)
Valley of Forgetting
Alzheimer's Families and the Search for a Cure
Failed to add items
Add to Cart failed.
Add to Wish List failed.
Remove from wishlist failed.
Adding to library failed
Follow podcast failed
Unfollow podcast failed
![Prime logo](https://m.media-amazon.com/images/G/01/Audible/Homestead/Prime_Logo_RGB.png)
Get 2 free audiobooks during trial.
Pre-order for $20.48
No default payment method selected.
We are sorry. We are not allowed to sell this product with the selected payment method
-
Narrated by:
About this listen
The riveting account of a community from the remote mountains of Colombia whose rare and fatal genetic mutation is unlocking the secrets of Alzheimer’s disease
In the 1980s, a neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For centuries, residents of certain villages near Medellín had suffered memory loss as they reached middle age, going on to die in their fifties. Lopera discovered that a unique genetic mutation was causing their rare hereditary form of early onset Alzheimer’s disease. Over the next forty years of working with the “paisa mutation” kindred, he went on to build a world-class research program in a region beset by violence and poverty.
In Valley of Forgetting, Jennie Erin Smith brings listeners into the clinic, the laboratories, and the Medellín trial center where Lopera’s patients receive an experimental drug to see if Alzheimer’s can be averted. She chronicles the lives of people who care for sick parents, spouses, and siblings, all while struggling to keep their own dreams afloat. These Colombian families have donated hundreds of their loved ones’ brains to science and subjected themselves to invasive testing to help uncover how Alzheimer’s develops and whether it can be stopped. Findings from this unprecedented effort could hold the key to understanding and treating the disease, though it is unclear what, if anything, the families will receive in return.
Smith’s immersive storytelling brings this complex drama to life, inviting listeners on a scientific journey that is as deeply moving as it is engrossing.
Related to this topic
-
My Big TOE: Awakening
- Book One of a Trilogy Unifying Philosophy, Physics, and Metaphysics
- By: Thomas Campbell
- Narrated by: Thomas Campbell
- Length: 11 hrs and 11 mins
- Unabridged
-
Overall
-
Performance
-
Story
My Big TOE: Awakening, written by a nuclear physicist in the language of contemporary culture, unifies science and philosophy, physics and metaphysics, mind and matter, purpose and meaning, the normal and the paranormal. The entirety of human experience (mind, body, and spirit) including both our objective and subjective worlds is brought together under one seamless scientific understanding.
-
-
What a Trip (but to where?)
- By Michael on 11-26-13
By: Thomas Campbell
-
Brain Energy
- A Revolutionary Breakthrough in Understanding Mental Health—and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More
- By: Christopher M. Palmer MD
- Narrated by: Christopher M. Palmer MD
- Length: 12 hrs and 18 mins
- Unabridged
-
Overall
-
Performance
-
Story
We are in the midst of a global mental health crisis, and mental illnesses are on the rise. But what causes mental illness? And why are mental health problems so hard to treat? Drawing on decades of research, Harvard psychiatrist Dr. Chris Palmer outlines a revolutionary new understanding that for the first time unites our existing knowledge about mental illness within a single framework: mental disorders are metabolic disorders of the brain. Brain Energy will transform the field of mental health, and the lives of countless people around the world.
-
-
Arguing brain health theory to medical profession
- By Maya H Saric on 03-10-23
-
Chemistry and Our Universe
- How It All Works
- By: Ron B. Davis, The Great Courses
- Narrated by: Ron B. Davis
- Length: 30 hrs and 6 mins
- Original Recording
-
Overall
-
Performance
-
Story
Chemistry and Our Universe: How It All Works is your in-depth introduction to this vital field, taught through 60 engaging half-hour lectures that are suitable for any background or none at all. Covering a year’s worth of introductory general chemistry at the college level, plus intriguing topics that are rarely discussed in the classroom, this amazingly comprehensive course requires nothing more advanced than high-school math. Your guide is Professor Ron B. Davis, Jr., a research chemist and award-winning teacher at Georgetown University.
-
-
Great Professor, Hard to Follow.
- By Jen on 05-14-19
By: Ron B. Davis, and others
-
Welcome to the Universe
- An Astrophysical Tour
- By: Michael A. Strauss, J. Richard Gott, Neil deGrasse Tyson
- Narrated by: Michael Butler Murray
- Length: 17 hrs and 53 mins
- Unabridged
-
Overall
-
Performance
-
Story
Welcome to the Universe is a personal guided tour of the cosmos by three of today's leading astrophysicists. Inspired by the enormously popular introductory astronomy course that Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott taught together at Princeton, this book covers it all - from planets, stars, and galaxies to black holes, wormholes, and time travel.
-
-
All About What We Know About the Universe - ALL
- By J.B. on 02-17-17
By: Michael A. Strauss, and others
-
The Selfish Gene
- By: Richard Dawkins
- Narrated by: Richard Dawkins, Lalla Ward
- Length: 16 hrs and 12 mins
- Unabridged
-
Overall
-
Performance
-
Story
Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.
-
-
Better than print!
- By J. D. May on 07-31-12
By: Richard Dawkins
-
Napoleon's Hemorrhoids…And Other Small Events That Changed History
- By: Phil Mason
- Narrated by: LJ Ganser
- Length: 8 hrs and 13 mins
- Unabridged
-
Overall
-
Performance
-
Story
Hilarious, fascinating, and a roller coaster of dizzying, historical what-ifs, Napoleon's Hemorrhoids is a potpourri for serious historians and casual history buffs. In one of Phil Mason's many revelations, you'll learn that Communist jets were two minutes away from opening fire on American planes during the Cuban missile crisis, when they had to turn back as they were running out of fuel. You'll discover that before the Battle of Waterloo, Napoleon's painful hemorrhoids prevented him from mounting his horse to survey the battlefield.
-
-
They just throw the facts too fast
- By Concerned_llama on 12-11-20
By: Phil Mason
-
My Big TOE: Awakening
- Book One of a Trilogy Unifying Philosophy, Physics, and Metaphysics
- By: Thomas Campbell
- Narrated by: Thomas Campbell
- Length: 11 hrs and 11 mins
- Unabridged
-
Overall
-
Performance
-
Story
My Big TOE: Awakening, written by a nuclear physicist in the language of contemporary culture, unifies science and philosophy, physics and metaphysics, mind and matter, purpose and meaning, the normal and the paranormal. The entirety of human experience (mind, body, and spirit) including both our objective and subjective worlds is brought together under one seamless scientific understanding.
-
-
What a Trip (but to where?)
- By Michael on 11-26-13
By: Thomas Campbell
-
Brain Energy
- A Revolutionary Breakthrough in Understanding Mental Health—and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More
- By: Christopher M. Palmer MD
- Narrated by: Christopher M. Palmer MD
- Length: 12 hrs and 18 mins
- Unabridged
-
Overall
-
Performance
-
Story
We are in the midst of a global mental health crisis, and mental illnesses are on the rise. But what causes mental illness? And why are mental health problems so hard to treat? Drawing on decades of research, Harvard psychiatrist Dr. Chris Palmer outlines a revolutionary new understanding that for the first time unites our existing knowledge about mental illness within a single framework: mental disorders are metabolic disorders of the brain. Brain Energy will transform the field of mental health, and the lives of countless people around the world.
-
-
Arguing brain health theory to medical profession
- By Maya H Saric on 03-10-23
-
Chemistry and Our Universe
- How It All Works
- By: Ron B. Davis, The Great Courses
- Narrated by: Ron B. Davis
- Length: 30 hrs and 6 mins
- Original Recording
-
Overall
-
Performance
-
Story
Chemistry and Our Universe: How It All Works is your in-depth introduction to this vital field, taught through 60 engaging half-hour lectures that are suitable for any background or none at all. Covering a year’s worth of introductory general chemistry at the college level, plus intriguing topics that are rarely discussed in the classroom, this amazingly comprehensive course requires nothing more advanced than high-school math. Your guide is Professor Ron B. Davis, Jr., a research chemist and award-winning teacher at Georgetown University.
-
-
Great Professor, Hard to Follow.
- By Jen on 05-14-19
By: Ron B. Davis, and others
-
Welcome to the Universe
- An Astrophysical Tour
- By: Michael A. Strauss, J. Richard Gott, Neil deGrasse Tyson
- Narrated by: Michael Butler Murray
- Length: 17 hrs and 53 mins
- Unabridged
-
Overall
-
Performance
-
Story
Welcome to the Universe is a personal guided tour of the cosmos by three of today's leading astrophysicists. Inspired by the enormously popular introductory astronomy course that Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott taught together at Princeton, this book covers it all - from planets, stars, and galaxies to black holes, wormholes, and time travel.
-
-
All About What We Know About the Universe - ALL
- By J.B. on 02-17-17
By: Michael A. Strauss, and others
-
The Selfish Gene
- By: Richard Dawkins
- Narrated by: Richard Dawkins, Lalla Ward
- Length: 16 hrs and 12 mins
- Unabridged
-
Overall
-
Performance
-
Story
Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.
-
-
Better than print!
- By J. D. May on 07-31-12
By: Richard Dawkins
-
Napoleon's Hemorrhoids…And Other Small Events That Changed History
- By: Phil Mason
- Narrated by: LJ Ganser
- Length: 8 hrs and 13 mins
- Unabridged
-
Overall
-
Performance
-
Story
Hilarious, fascinating, and a roller coaster of dizzying, historical what-ifs, Napoleon's Hemorrhoids is a potpourri for serious historians and casual history buffs. In one of Phil Mason's many revelations, you'll learn that Communist jets were two minutes away from opening fire on American planes during the Cuban missile crisis, when they had to turn back as they were running out of fuel. You'll discover that before the Battle of Waterloo, Napoleon's painful hemorrhoids prevented him from mounting his horse to survey the battlefield.
-
-
They just throw the facts too fast
- By Concerned_llama on 12-11-20
By: Phil Mason
-
How the Earth Works
- By: Michael E. Wysession, The Great Courses
- Narrated by: Michael E. Wysession
- Length: 24 hrs and 31 mins
- Original Recording
-
Overall
-
Performance
-
Story
How the Earth Works takes you on an astonishing journey through time and space. In 48 lectures, you will look at what went into making our planet - from the big bang, to the formation of the solar system, to the subsequent evolution of Earth.
-
-
Excellent course
- By Doug B. on 05-23-19
By: Michael E. Wysession, and others
-
Letters from an Astrophysicist
- By: Neil deGrasse Tyson
- Narrated by: Neil deGrasse Tyson, Vikas Adam, Piper Goodeve, and others
- Length: 5 hrs and 35 mins
- Unabridged
-
Overall
-
Performance
-
Story
Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.
-
-
Dear Neil...
- By Tina G. on 10-14-19
-
The Last Season
- By: Eric Blehm
- Narrated by: Jonathan Davis
- Length: 12 hrs and 34 mins
- Unabridged
-
Overall
-
Performance
-
Story
Destined to become a classic of adventure literature, The Last Season examines the extraordinary life of legendary backcountry ranger Randy Morgenson and his mysterious disappearance in California's unforgiving Sierra Nevada - mountains as perilous as they are beautiful. Eric Blehm's masterful work is a gripping detective story interwoven with the riveting biography of a complicated, original, and wholly fascinating man.
-
-
Well Written Character Study of an NPS Ranger
- By Kathy in CA on 06-23-16
By: Eric Blehm
-
Your Brain Is a Time Machine
- The Neuroscience and Physics of Time
- By: Dean Buonomano
- Narrated by: Aaron Abano
- Length: 8 hrs and 51 mins
- Unabridged
-
Overall
-
Performance
-
Story
In Your Brain Is a Time Machine, brain researcher and best-selling author Dean Buonomano draws on evolutionary biology, physics, and philosophy to present his influential theory of how we tell and perceive time. The human brain, he argues, is a complex system that not only tells time but creates it; it constructs our sense of chronological flow and enables "mental time travel" - simulations of future and past events.
-
-
Great book on an underrated subject
- By Neuron on 05-09-17
By: Dean Buonomano
-
Inspired
- How to Create Tech Products Customers Love, Second Edition
- By: Marty Cagan
- Narrated by: Marty Cagan
- Length: 7 hrs and 45 mins
- Unabridged
-
Overall
-
Performance
-
Story
How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.
-
-
Great book, terrible audio wanted to ask a refund
- By Srikanth Ramanujam on 11-15-18
By: Marty Cagan
-
Secrets of the Octopus
- By: Sy Montgomery, Warren K. Carlyle IV - contributor, Alex Schnell - foreword
- Narrated by: Sy Montgomery
- Length: 4 hrs and 30 mins
- Unabridged
-
Overall
-
Performance
-
Story
Remarkable new discoveries affirm the octopus as one of nature’s most intelligent and complex animals. This new book brings us closer than ever to these elusive creatures. The companion to the highly anticipated National Geographic television special, this book explores the alluring underwater world of the octopus—a creature that resembles an alien lifeform, but whose behavior has earned it a reputation as one of the most intelligent animals on the planet.
-
-
An okay listen
- By Tae Bailon on 01-24-25
By: Sy Montgomery, and others
People who viewed this also viewed...
-
Beast in the Machine
- How Robotics and AI Will Transform Warfare and the Future of Human Conflict
- By: George Dougherty
- Length: 10 hrs
- Unabridged
-
Overall
-
Performance
-
Story
A defense technology expert and military leader reveals the future of robotic warfare, and illuminates the path to navigate the approaching storm of global change.
By: George Dougherty
-
To Lose a War
- The Fall and Rise of the Taliban
- By: Jon Lee Anderson
- Length: 12 hrs
- Unabridged
-
Overall
-
Performance
-
Story
From one of the greatest foreign correspondents of our time, whose essential and profound on the ground reporting from Afghanistan for The New Yorker from before 9/11 to the return of the Taliban to power in 2021 has definitively shaped our understanding of the country and its fate, comes the complete accounting of that era, combining previously published dispatches and new reporting into a narrative of great impact and lasting value.
By: Jon Lee Anderson
-
Apocalypse
- How Catastrophe Transformed Our World and Can Forge New Futures
- By: Lizzie Wade
- Narrated by: Christina Delaine
- Length: 10 hrs and 30 mins
- Unabridged
-
Overall
-
Performance
-
Story
A drought lasts for decades, a disease rips through a city, a civilization collapses. When we finally uncover the ruins, we ask: what happened? The good news is, we’ve been here before. History is long, and people have already confronted just about every apocalypse we’re facing today. But these days, archaeologists are getting better at seeing stories of survival, transformation, and even progress hidden within those histories of collapse and destruction. Perhaps, we begin to see, apocalypses do not destroy, but create, new worlds.
By: Lizzie Wade
-
Miracles and Wonder
- The Historical Mystery of Jesus
- By: Elaine Pagels
- Length: 15 hrs
- Unabridged
-
Overall
-
Performance
-
Story
Early in her career, Elaine Pagels changed our understanding of the origins of Christianity with her work in The Gnostic Gospels. Now, in the culmination of a decades-long career, she explores the biggest subject of all, Jesus. In Miracles and Wonder she sets out to discover how a poor young Jewish man inspired a religion that shaped the world.
By: Elaine Pagels
-
The Mesopotamian Riddle
- An Archaeologist, a Soldier, a Clergyman and the Race to Decipher the World's Oldest Writing
- By: Joshua Hammer
- Narrated by: Matthew Lloyd Davies
- Length: 10 hrs and 32 mins
- Unabridged
-
Overall
-
Performance
-
Story
From the ruins of Persepolis to lawless outposts of the crumbling Ottoman Empire, The Mesopotamian Riddle whisks you on a wild adventure through the golden age of archaeology in an epic quest to understand our past.
By: Joshua Hammer
-
The Place of Tides
- By: James Rebanks
- Length: 12 hrs
- Unabridged
-
Overall
-
Performance
-
Story
One afternoon many years ago, James Rebanks met an old woman on a remote Norwegian island. She lived and worked alone on a tiny rocky outcrop, caring for wild Eider ducks and gathering their down. Hers was a centuries-old trade that had once made men and women rich but had long been in decline. Still, somehow, she seemed to be hanging on. Back at home, Rebanks couldn’t stop thinking about the woman on the rocks. She was fierce and otherworldly—and yet strangely familiar.
By: James Rebanks
-
Beast in the Machine
- How Robotics and AI Will Transform Warfare and the Future of Human Conflict
- By: George Dougherty
- Length: 10 hrs
- Unabridged
-
Overall
-
Performance
-
Story
A defense technology expert and military leader reveals the future of robotic warfare, and illuminates the path to navigate the approaching storm of global change.
By: George Dougherty
-
To Lose a War
- The Fall and Rise of the Taliban
- By: Jon Lee Anderson
- Length: 12 hrs
- Unabridged
-
Overall
-
Performance
-
Story
From one of the greatest foreign correspondents of our time, whose essential and profound on the ground reporting from Afghanistan for The New Yorker from before 9/11 to the return of the Taliban to power in 2021 has definitively shaped our understanding of the country and its fate, comes the complete accounting of that era, combining previously published dispatches and new reporting into a narrative of great impact and lasting value.
By: Jon Lee Anderson
-
Apocalypse
- How Catastrophe Transformed Our World and Can Forge New Futures
- By: Lizzie Wade
- Narrated by: Christina Delaine
- Length: 10 hrs and 30 mins
- Unabridged
-
Overall
-
Performance
-
Story
A drought lasts for decades, a disease rips through a city, a civilization collapses. When we finally uncover the ruins, we ask: what happened? The good news is, we’ve been here before. History is long, and people have already confronted just about every apocalypse we’re facing today. But these days, archaeologists are getting better at seeing stories of survival, transformation, and even progress hidden within those histories of collapse and destruction. Perhaps, we begin to see, apocalypses do not destroy, but create, new worlds.
By: Lizzie Wade
-
Miracles and Wonder
- The Historical Mystery of Jesus
- By: Elaine Pagels
- Length: 15 hrs
- Unabridged
-
Overall
-
Performance
-
Story
Early in her career, Elaine Pagels changed our understanding of the origins of Christianity with her work in The Gnostic Gospels. Now, in the culmination of a decades-long career, she explores the biggest subject of all, Jesus. In Miracles and Wonder she sets out to discover how a poor young Jewish man inspired a religion that shaped the world.
By: Elaine Pagels
-
The Mesopotamian Riddle
- An Archaeologist, a Soldier, a Clergyman and the Race to Decipher the World's Oldest Writing
- By: Joshua Hammer
- Narrated by: Matthew Lloyd Davies
- Length: 10 hrs and 32 mins
- Unabridged
-
Overall
-
Performance
-
Story
From the ruins of Persepolis to lawless outposts of the crumbling Ottoman Empire, The Mesopotamian Riddle whisks you on a wild adventure through the golden age of archaeology in an epic quest to understand our past.
By: Joshua Hammer
-
The Place of Tides
- By: James Rebanks
- Length: 12 hrs
- Unabridged
-
Overall
-
Performance
-
Story
One afternoon many years ago, James Rebanks met an old woman on a remote Norwegian island. She lived and worked alone on a tiny rocky outcrop, caring for wild Eider ducks and gathering their down. Hers was a centuries-old trade that had once made men and women rich but had long been in decline. Still, somehow, she seemed to be hanging on. Back at home, Rebanks couldn’t stop thinking about the woman on the rocks. She was fierce and otherworldly—and yet strangely familiar.
By: James Rebanks