The Master Builder
How the New Science of the Cell Is Rewriting the Story of Life
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Narrated by:
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Gareth Armstrong
About this listen
A leading developmental biologist argues that cells, not DNA, hold the key to understanding history, present, and future of life.
What defines who we are?
For decades, the biological answer has been our genes. In The Master Builder, leading biologist Alfonso Martinez Arias breaks with decades of scientific and popular tradition to make a bold argument: what defines us is our cells. Drawing on new research from his lab and others, Martinez Arias reveals that we are composed of a thrillingly complex, constantly rearranging symphony of cells that know how to count, feel, and ultimately give form to our bodies. While DNA is important, Richard Dawkins's vision of the selfish gene that controls everything is not a good description of how biology actually works. As Martinez Arias shows, nothing in your genes explains why your heart is on the left side of your body, why you have five fingers and not ten, or why genetically identical twins have different sets of fingerprints and why it's possible for a mother to apparently share no DNA with the children to whom she gave birth! At the heart of it all is not simply gee-whiz science, but a powerful new conception of the essence of life.
Our identities are shaped not simply by our genes, but by the interconnections between all our cells, working as a sort of symphony-cooperative, and creating something greater than its parts could on their own-and the unbroken lineage of cells that connects us to the first fertilized egg from which we developed - and in turn, back through the billions of years of our planet's history, to the very first cell in the history of all life on Earth.
A sweeping revision of both the present and history of life, The Master Builder puts forward a new paradigm for understanding biology, one rooted in cellular cooperation, not selfish genes. Engaging and ambitious, it will transform our understanding of where we come from, what shapes us, and where we are going, as individuals, a species, and the community of life itself.
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Alfonso Martinez Arias makes a timely, important and compelling case for why an understanding of living organisms must start with the cell. He offers a vision of life that shows it to be much more interesting and ingenious than any simplistic notion of genetic blueprints can provide. (Philip Ball, author of CRITICAL MASS and THE BOOK OF MINDS)
The essence of science is that we never stop asking, do we see clearly, or have we fooled ourselves into certainty? In The Master Builder, we follow that question into the cell, where DNA is said to rule. What Alfonso Martinez-Arias has found is much more interesting: cells themselves, which we inherited from a long line of ancestors stretching back to the earliest life, are at least as integral to creating who we are as the genes each carries. This book makes a new and stunning argument, not so much that we should put DNA in its place, but that we can see the grandeur of life as it truly is. (Azra Raza, author of THE FIRST CELL)
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Who knew?
- By Fitmen on 04-25-18
By: Liam Drew
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How to Build a Dinosaur
- Extinction Doesn't Have to Be Forever
- By: Jack Horner, James Gorman
- Narrated by: Patrick Lawlor
- Length: 6 hrs and 36 mins
- Unabridged
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In movies, in novels, in comic strips, and on television, we've all seen dinosaurs - or at least somebody's educated guess of what they would look like. But what if it were possible to build, or grow, a real dinosaur without finding ancient DNA? Jack Horner, the scientist who advised Steven Spielberg on the blockbuster film Jurassic Park and a pioneer in bringing paleontology into the 21st century, teams up with the editor of the New York Times's Science Times section to reveal exactly what's in store.
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Good book but misplaced title
- By Robert on 06-19-15
By: Jack Horner, and others
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Evolving Ourselves
- How Unnatural Selection and Nonrandom Mutation are Changing Life on Earth
- By: Juan Enriquez, Steve Gullans
- Narrated by: Rob Shapiro
- Length: 10 hrs and 50 mins
- Unabridged
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Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?
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fascinating ideas and science
- By Joel on 07-04-15
By: Juan Enriquez, and others
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Arrival of the Fittest
- Solving Evolution's Greatest Puzzle
- By: Andreas Wagner
- Narrated by: Sean Pratt
- Length: 8 hrs and 29 mins
- Unabridged
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In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over 15 years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.
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Robustness makes for an interesting life and book
- By Gary on 11-29-14
By: Andreas Wagner
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A Series of Fortunate Events
- Chance and the Making of the Planet, Life, and You
- By: Sean B. Carroll
- Narrated by: Sean B. Carroll
- Length: 4 hrs and 48 mins
- Unabridged
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Why is the world the way it is? How did we get here? Does everything happen for a reason, or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world.
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We are for a short time.
- By Anonymous User on 10-14-20
By: Sean B. Carroll
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The Vital Question
- Energy, Evolution, and the Origins of Complex Life
- By: Nick Lane
- Narrated by: Kevin Pariseau
- Length: 11 hrs and 27 mins
- Unabridged
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The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.
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Ouch!
- By Mark on 06-24-16
By: Nick Lane
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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Herding Hemingway's Cats
- Understanding How Our Genes Work
- By: Kat Arney
- Narrated by: Kat Arney
- Length: 8 hrs and 39 mins
- Unabridged
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The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work?
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A non-scientists misguided interpretation
- By AraSevera on 05-15-16
By: Kat Arney
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How to Clone a Mammoth
- The Science of De-Extinction
- By: Beth Shapiro
- Narrated by: Coleen Marlo
- Length: 7 hrs and 13 mins
- Unabridged
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Could extinct species, like mammoths and passenger pigeons, be brought back to life? The science says yes. In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks listeners through the astonishing and controversial process of de-extinction.
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Very Readable Take on a Complex Subject
- By John on 04-26-15
By: Beth Shapiro
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Human Errors
- A Panorama of Our Glitches, from Pointless Bones to Broken Genes
- By: Nathan H. Lents
- Narrated by: L.J. Ganser
- Length: 7 hrs and 54 mins
- Unabridged
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We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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From Pointless Bones to Broken Genes to...Aliens?
- By Katy.LED on 12-04-18
By: Nathan H. Lents
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- By: Daniel M. Davis
- Narrated by: Christopher Grove
- Length: 7 hrs and 48 mins
- Unabridged
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Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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If interested in medicine, got to read
- By Howard Sterling on 06-29-16
By: Daniel M. Davis
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The Blind Watchmaker
- Why the Evidence of Evolution Reveals a Universe Without Design
- By: Richard Dawkins
- Narrated by: Richard Dawkins, Lalla Ward
- Length: 14 hrs and 40 mins
- Unabridged
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The Blind Watchmaker, knowledgably narrated by author Richard Dawkins, is as prescient and timely a book as ever. The watchmaker belongs to the 18th-century theologian William Paley, who argued that just as a watch is too complicated and functional to have sprung into existence by accident, so too must all living things, with their far greater complexity, be purposefully designed. Charles Darwin's brilliant discovery challenged the creationist arguments; but only Richard Dawkins could have written this elegant riposte.
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Challenging textbook more than an enjoyable listen
- By Eric on 01-15-12
By: Richard Dawkins
What listeners say about The Master Builder
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Jurisa-San
- 11-20-23
Never thought that cell is so amazing.
This audiobook is exceptionally interesting. It explores the fascinating and intriguing aspects of biology as a science that I never knew, e.g. how and when live cell has obtained methahondria. I would recommend it to anyone who wants to learn more about their amazing body.
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