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So Simple a Beginning
- How Four Physical Principles Shape Our Living World
- Narrated by: Anand Jagatia
- Length: 9 hrs and 25 mins
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Publisher's summary
This audiobook narrated by Anand Jagatia reveals the hidden unity behind nature’s breathtaking complexity.
The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering.
Raghuveer Parthasarathy explains how four basic principles - self-assembly, regulatory circuits, predictable randomness, and scaling - shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound.
This sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning.
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Story
The cells in our bodies consist of molecules, made up of the same carbon, oxygen, and hydrogen atoms found in air and rocks. But molecules, such as water and sugar, are not alive. So how do our cells - assemblies of otherwise "dead" molecules - come to life, and together constitute a living being? In Life’s Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale.
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For biologists to learn single molecule biophysics
- By A Synthetic Biologist on 09-04-14
By: Peter M. Hoffman
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Life's Engines
- How Microbes Made Earth Habitable
- By: Paul G. Falkowski
- Narrated by: Nick Sullivan
- Length: 7 hrs and 22 mins
- Unabridged
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Paul Falkowski looks "under the hood" of microbes to find the engines of life, the actual working parts that do the biochemical heavy lifting for every living organism on Earth. With insight and humor, he explains how these miniature engines are built - and how they have been appropriated by and assembled like Lego sets within every creature that walks, swims, or flies. Falkowski shows how evolution works to maintain this core machinery of life, and how we and other animals are veritable conglomerations of microbes.
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Best Science Book Ever Written. Period.
- By serine on 07-28-15
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The Gene
- An Intimate History
- By: Siddhartha Mukherjee
- Narrated by: Dennis Boutsikaris
- Length: 19 hrs and 22 mins
- Unabridged
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The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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It's a Wonderful Book
- By JKC on 06-02-16
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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How to Build a Dinosaur
- Extinction Doesn't Have to Be Forever
- By: Jack Horner, James Gorman
- Narrated by: Patrick Lawlor
- Length: 6 hrs and 36 mins
- Unabridged
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In movies, in novels, in comic strips, and on television, we've all seen dinosaurs - or at least somebody's educated guess of what they would look like. But what if it were possible to build, or grow, a real dinosaur without finding ancient DNA? Jack Horner, the scientist who advised Steven Spielberg on the blockbuster film Jurassic Park and a pioneer in bringing paleontology into the 21st century, teams up with the editor of the New York Times's Science Times section to reveal exactly what's in store.
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Good book but misplaced title
- By Robert on 06-19-15
By: Jack Horner, and others
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At the Edge of Uncertainty
- 11 Discoveries Taking Science by Surprise
- By: Michael Brooks
- Narrated by: Sean Runnette
- Length: 9 hrs and 12 mins
- Unabridged
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The atom, the big bang, DNA, natural selection - all are ideas that have revolutionized science; and all were dismissed out of hand when they first appeared. The surprises haven't stopped in recent years, and in At the Edge of Uncertainty, best-selling author Michael Brooks investigates the new wave of radical insights that are shaping the future of scientific discovery.
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All smoke, no fire
- By Kenton on 07-25-15
By: Michael Brooks
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The Blind Watchmaker
- Why the Evidence of Evolution Reveals a Universe Without Design
- By: Richard Dawkins
- Narrated by: Richard Dawkins, Lalla Ward
- Length: 14 hrs and 40 mins
- Unabridged
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The Blind Watchmaker, knowledgably narrated by author Richard Dawkins, is as prescient and timely a book as ever. The watchmaker belongs to the 18th-century theologian William Paley, who argued that just as a watch is too complicated and functional to have sprung into existence by accident, so too must all living things, with their far greater complexity, be purposefully designed. Charles Darwin's brilliant discovery challenged the creationist arguments; but only Richard Dawkins could have written this elegant riposte.
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Challenging textbook more than an enjoyable listen
- By Eric on 01-15-12
By: Richard Dawkins
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A Series of Fortunate Events
- Chance and the Making of the Planet, Life, and You
- By: Sean B. Carroll
- Narrated by: Sean B. Carroll
- Length: 4 hrs and 48 mins
- Unabridged
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Why is the world the way it is? How did we get here? Does everything happen for a reason, or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world.
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We are for a short time.
- By Anonymous User on 10-14-20
By: Sean B. Carroll
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What Is Life?
- How Chemistry Becomes Biology
- By: Addy Pross
- Narrated by: Derek Perkins
- Length: 6 hrs and 50 mins
- Unabridged
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Seventy years ago, Erwin Schrdinger posed a simple, yet profound, question: What is life?. How could the very existence of such extraordinary chemical systems be understood? This problem has puzzled biologists and physical scientists both before, and ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology?
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Profound & Life Changing...
- By Daegan Smith on 04-06-15
By: Addy Pross
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I, Mammal
- By: Liam Drew
- Narrated by: Neil Gardner
- Length: 11 hrs and 26 mins
- Unabridged
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A list of the attributes that define a mammal is a ragbag of things - fur, live birth, three bones in the middle ear, a brain whose two halves are robustly joined together.... But this curious collection of features contain the roots of all the biology that makes us what we are: monkeys with massive brains who parent extensively, enjoy sport and think lots. Which is to say, what makes us mammals makes us human.
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Who knew?
- By Fitmen on 04-25-18
By: Liam Drew
What listeners say about So Simple a Beginning
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Anonymous User
- 04-11-22
Nano details, single DNA egg strand extraction
Beads on a String, The Who sings, to get us together like "Beads on a String" or DNA wrapped histones, described, by this writer as beads on a string.
Need to read again is ultimate praise. Easy to mistake new science as tough reading or writing. Taking a DNA strand, fixing cystic fibrosis, re-itntroducing it to follow an egg to a complex human.
Hear about nodules, becoming arms and legs.
A 30 second rewind is audio science delight! If you're a science lover this is new author also.
Biophysics and mechanobiology will have great new books coming. Life's Rachet, I think author Pullman?
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- David
- 04-03-22
If you enjoy genetics, physics, and math ...
I personally particularly enjoy books that make broad connections across math and science, like Geoffrey West's "Scale," Bill Bryson's "A Short History ...", and Strogratz's "Sync:..." If you have similar interests and a particular interest in genetics, "So Simple a Beginning" should be a great fit.
It's essentially two parts. The first half covers a few common themes that unify and permeate biology: self-assembly, predictable randomness, regulatory networks, and scale, I found discussions about how mathematical principles like Random Walks combined with physical properties like Reynolds Numbers and viscosity influence biological concerns like appendages for motion.
The second half focuses more squarely on genetics and genetics engineering with fairly lucid explanations of PCR (polymerase chain reaction), gene sequencing, CRISPR-based gene editing. and several other biotech buzzwords.
One particular note I found refreshing is that although, like many books on genetics, the author includes a fair bit of ethical discussion, he does so without overly pushing a particular moral or ethical worldview and instead seems to respect differing viewpoints.
I wish the first part of the book could have been a little longer, perhaps diving more into emergent phenomena, which he approaches with a couple of the four principles, but without ever outright using the term. It almost seems like memory mechanisms, as in immunity and DNA itself, are a fifth principle that allows continual accumulation of advances and increasingly complex emergent phenomena. But I suppose no such book is ever complete.
On the whole, a great job in a broad and interesting topic.
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