
Breaking Through
My Life in Science
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Narrated by:
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Eva Magyar
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By:
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Katalin Karikó
About this listen
A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines
“Katalin Karikó’s story is an inspiration.”—Bill Gates
“Riveting . . . a true story of a brilliant biochemist who never gave up or gave in.”—Bonnie Garmus, author of Lessons in Chemistry
A KIRKUS REVIEWS BEST BOOK OF THE YEAR
Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine.
Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.
Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines—for the flu, HIV, and other emerging infectious diseases.
Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity—knowing she might never be recognized in a culture that is driven by prestige, power, and privilege—because she believed her work would save lives.
©2023 Katalin Karikó (P)2023 Random House AudioListeners also enjoyed...
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Critic reviews
“A riveting testament to resilience and the power of unwavering belief, Breaking Through charts an inspirational journey from growing up in postwar communist Hungary to transforming the world with mRNA.”—Jennifer Doudna, Nobel Prize laureate in chemistry and author of A Crack in Creation
“Katalin Karikó’s story is an inspiration. Anyone who has ever doubted that science, innovation, and persistence can change the world should read this book.”—Bill Gates, #1 New York Times bestselling author of How to Avoid a Climate Disaster
“Karikó’s proven recipe (from the creative Hungarian kitchen) for a breakthrough in science: Start with an insatiable curiosity in education and research. Then, for a few decades, look for gaps in knowledge; work hard for years to fill some of them; don’t give up because of difficulties or circumstances; and, finally, seize the opportunity to help solve one painful problem of humanity, thereby opening new horizons for the future of medicine. Bon appétit, enjoy your sweets!”—Ernő Rubik, inventor of the Rubik’s Cube and author of Cubed
“Katalin Karikó’s remarkable life story, which incidentally began not far from where I spent my childhood, inspires us not to be held back even in the face of severe difficulties. It encourages us to stay strong and follow through with important ideas that can change the world.”—Stefan Hell, Nobel Prize laureate in chemistry
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- Narrated by: Micaela Blei
- Length: 2 hrs and 48 mins
- Original Recording
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It’s 2006. After a string of rejections from men who tell her they could never, ever, ever see her “that way,” awkward third-grade teacher Micaela Blei signs up for a mysterious course called “The Divine Feminine,” and feels like she might have found the key to the perfect life. Turns out if you’re an A student, you can get an A in anything–including men. Pretty soon she’s learning to "conjure" her desires with vision boards, flirtations, and even a daring jumbotron viewing party for her, ahem ... "divine center."
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Humor, Humanity, and the Heart of Self-Love
- By David on 12-12-24
By: Micaela Blei
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The Unusual Suspects with Kenya Barris and Malcolm Gladwell
- By: Kenya Barris, Malcolm Gladwell
- Narrated by: Kenya Barris, Malcolm Gladwell
- Length: 7 hrs and 23 mins
- Original Recording
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Join Kenya Barris and Malcolm Gladwell as they bypass pleasantries and promotional banter to deliver raw, unfiltered conversations with some of today’s most influential figures. Featuring titans across a spectrum of professions (from Olympic gold medalists to trailblazing Fortune 500 CEOs and everything in between), The Unusual Suspects with Kenya Barris and Malcolm Gladwell pulls back the curtain to offer listeners unprecedented access to the minds of the world’s most extraordinary individuals and their distinct paths to success.
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UNusually Great!
- By Angela C. on 01-30-25
By: Kenya Barris, and others
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Going Infinite
- The Rise and Fall of a New Tycoon
- By: Michael Lewis
- Narrated by: Michael Lewis
- Length: 9 hrs and 35 mins
- Unabridged
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Overall
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Performance
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Story
When Michael Lewis first met him, Sam Bankman-Fried was the world’s youngest billionaire and crypto’s Gatsby. CEOs, celebrities, and leaders of small countries all vied for his time and cash after he catapulted, practically overnight, onto the Forbes billionaire list. Who was this rumpled guy in cargo shorts and limp white socks, whose eyes twitched across Zoom meetings as he played video games on the side?
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really expected more rigor from Michael Lewis
- By Wowhello on 10-04-23
By: Michael Lewis
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The Demon Next Door
- By: Bryan Burrough
- Narrated by: Steve White
- Length: 2 hrs and 45 mins
- Unabridged
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Performance
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Story
Best-selling author Bryan Burrough recently made a shocking discovery: The small town of Temple, Texas, where he had grown up, had harbored a dark secret. One of his high school classmates, Danny Corwin, was a vicious serial killer. In this chilling tale, Burrough raises important questions of whether serial killers can be recognized before they kill or rehabilitated after they do. It is also a story of Texas politics and power that led the good citizens of the town of Temple to enable a demon who was their worst nightmare.
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Odd narration choice
- By Amanda Fredericks on 03-08-19
By: Bryan Burrough
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The Madman's Hotel
- By: Niall Breslin
- Narrated by: Niall Breslin
- Length: 4 hrs and 4 mins
- Original Recording
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Story
In the heart of the rolling green hills of Ireland a huge abandoned psychiatric asylum looms large and holds its secrets close, until one family fights to find the truth about their long lost great grandmother. Presented by Irish celebrity and mental health advocate Niall Breslin - this is the untold story of the quest to find patient Julia Leonard, alongside many others, who came to die in St Loman’s Hospital near Dublin. Why was Julia in St Loman’s? And what happened to her and other patients who found themselves within its walls?
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Heart felt Remembrance
- By RosaInGlousta on 11-05-24
By: Niall Breslin
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I Can't Make This Up
- Life Lessons
- By: Neil Strauss - contributor, Kevin Hart
- Narrated by: Kevin Hart
- Length: 11 hrs and 15 mins
- Unabridged
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Story
Superstar comedian and Hollywood box-office star Kevin Hart turns his immense talent to the written word by writing some words. Some of those words include: the, a, for, above, and even even. Put them together and you have the funniest, most heartfelt, and most inspirational memoir on survival, success, and the importance of believing in yourself since Old Yeller.
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Best Audiobook I Ever Listened To
- By Sam Clear on 07-13-17
By: Neil Strauss - contributor, and others
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Genghis Khan and the Making of the Modern World
- By: Jack Weatherford
- Narrated by: Jonathan Davis, Jack Weatherford
- Length: 14 hrs and 20 mins
- Unabridged
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Overall
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Performance
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Story
The Mongol army led by Genghis Khan subjugated more lands and people in 25 years than the Romans did in 400. In nearly every country the Mongols conquered, they brought an unprecedented rise in cultural communication, expanded trade, and a blossoming of civilization.
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Golden Horde/Platinum Listen
- By Cynthia on 12-11-13
By: Jack Weatherford
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Elvis and Me
- By: Priscilla Beaulieu Presley
- Narrated by: Priscilla Beaulieu Presley
- Length: 7 hrs and 30 mins
- Unabridged
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Performance
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Story
The inspiration for the major motion picture Priscilla directed by Sofia Coppola, this New York Times best seller reveals the intimate story of Elvis Presley and Priscilla Presley, told by the woman who lived it.
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What a story!
- By Pen Name on 08-28-22
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My Mom's Murder
- By: AYR Media
- Narrated by: Lauren Malloy
- Length: 6 hrs and 35 mins
- Original Recording
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When a mysterious stranger unveils a long-hidden truth, Lauren Malloy’s life is thrown into chaos. For years, Lauren believed her mother, Lori, died of natural causes, but the shocking reality is that her loving mother was brutally murdered when Lauren was just an infant. Now, 30 years later, Lauren is on a relentless quest for justice. Over the past four years, she’s embarked on an emotional journey filled with unexpected twists, recording hundreds of hours of interviews with law enforcement, family, friends, and even potential suspects.
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The raw interviews.
- By knapper on 11-12-24
By: AYR Media
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The Great Gatsby at 100
- By: Sheila Liming, The Great Courses
- Narrated by: Sheila Liming
- Length: 2 hrs and 48 mins
- Original Recording
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In the six lectures of The Great Gatsby at 100, you will join Sheila Liming of Champlain College to revisit the context and culture of the Roaring ‘20s, which inspired the story of the mysterious Jay Gatsby and his disastrous pursuit of Daisy Buchanan. As you’ll discover, while Gatsby is framed as a love story, it’s also a story of the American experience, revealing the unspoken rules of wealth and class and the false promises of self-made success in a world of Old Money privilege.
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A couple fresh ideas
- By JLo on 04-11-25
By: Sheila Liming, and others
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Ghost
- My Thirty Years as an FBI Undercover Agent
- By: Michael R. McGowan, Ralph Pezzullo
- Narrated by: Mike Dawson
- Length: 8 hrs and 45 mins
- Unabridged
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Within FBI field operative circles, groups of people known as “Special” by their titles alone, Michael R. McGowan is an outlier. Over the course of his career, McGowan has worked more than 50 undercover cases. In this extraordinary and unprecedented book, McGowan will take listeners through some of his biggest cases, from international drug busts to the Russian and Italian mobs to biker gangs and contract killers to corrupt unions and SWAT work. Ghost is an unparalleled view into how the FBI, through the courage of its undercover Special Agents, nails the bad guys.
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Interesting story, but narration eh
- By Ahdumb on 10-06-18
By: Michael R. McGowan, and others
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Evil Has a Name
- The Untold Story of the Golden State Killer Investigation
- By: Paul Holes, Jim Clemente, Peter McDonnell
- Narrated by: Paul Holes, Jim Clemente
- Length: 6 hrs and 13 mins
- Original Recording
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For his victims, for their families and for the investigators tasked with finding him, the senselessness and brutality of the Golden State Killer's acts were matched only by the powerlessness they felt at failing to uncover his identity. Then, on April 24, 2018, authorities arrested 72-year-old Joseph James DeAngelo at his home in Citrus Heights, Calif., based on DNA evidence linked to the crimes. Amazingly, it seemed, evil finally had a name. Please note: This work contains descriptions of violent crime and sexual assault and may not be suitable for all listeners.
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Audible Raises The Bar On True Crime Genre
- By R. Squyres on 11-16-18
By: Paul Holes, and others
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The Autobiography of Malcolm X
- As Told to Alex Haley
- By: Malcolm X, Alex Haley
- Narrated by: Laurence Fishburne
- Length: 16 hrs and 52 mins
- Unabridged
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Experience a bold take on this classic autobiography as it’s performed by Oscar-nominated Laurence Fishburne. In this searing classic autobiography, originally published in 1965, Malcolm X, the Muslim leader, firebrand, and Black empowerment activist, tells the extraordinary story of his life and the growth of the Human Rights movement. His fascinating perspective on the lies and limitations of the American dream and the inherent racism in a society that denies its non-White citizens the opportunity to dream, gives extraordinary insight into the most urgent issues of our own time.
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it's Nearly perfect
- By Kerry on 09-16-20
By: Malcolm X, and others
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Ali in Me
- By: Mercury Studios, Treefort Media
- Narrated by: Lonnie Ali, John Ramsey
- Length: 3 hrs and 31 mins
- Original Recording
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Performance
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Story
Muhammad Ali, never afraid to express himself loudly and boldly, stays true to form in Ali in Me, an eight-part audio series that explores his life and legacy, guided by his own words through never-before-heard audio recordings. Hosted by Muhammad’s widow, Lonnie Ali, and his close friend, award-winning broadcaster John Ramsey, Ali in Me goes beyond the boxing ring to delve deeply into the extraordinary life and lasting contributions The Champ made to individuals around the world.
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He went hard on everything, especially love
- By 🔥 Phx17 🔥 on 01-31-25
By: Mercury Studios, and others
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Hunger Makes Me a Modern Girl
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From the guitarist of the pioneering band Sleater-Kinney, the book Kim Gordon says "everyone has been waiting for" and a New York Times Notable Book of 2015 - a candid, funny, and deeply personal look at making a life - and finding yourself - in music. Before Carrie Brownstein became a music icon, she was a young girl growing up in the Pacific Northwest just as it was becoming the setting for one the most important movements in rock history.
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fussy
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A Mother's Reckoning
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On April 20, 1999, Eric Harris and Dylan Klebold walked into Columbine High School in Littleton, Colorado. Over the course of minutes, they would kill 12 students and a teacher and wound 24 others before taking their own lives. For the last 16 years, Sue Klebold, Dylan's mother, has lived with the indescribable grief and shame of that day. How could her child, the promising young man she had loved and raised, be responsible for such horror? And how, as his mother, had she not known something was wrong?
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Sad, but, Ultimately, Self-Serving
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She was born in 1930 in El Paso and grew up on a cattle ranch in Arizona. At a time when women were expected to be homemakers, she set her sights on Stanford University. When she graduated near the top of her law school class in 1952, no firm would even interview her. But Sandra Day O’Connor’s story is that of a woman who repeatedly shattered glass ceilings - doing so with a blend of grace, wisdom, humor, understatement, and cowgirl toughness.
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Remarkable woman, well served in this book.
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In her current reign at Power 105.1 and for nearly two decades at New York's Hot 97, Angie Martinez has had one of the highest rated radio shows in the country. After working her way up as an intern, she burst on the scene as a young female jock whose on-air "Battle of the Beats" segment broke records and became a platform for emerging artists like a young Jay Z. Angie quickly became known for intimate, high-profile interviews, mediating feuds between artists, and taking on the most controversial issues in hip-hop.
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By: Angie Martinez, and others
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Under the Big Black Sun
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Under the Big Black Sun explores the nascent Los Angeles punk rock movement and its evolution to hardcore punk as it's never been told before. Authors John Doe and Tom DeSavia have woven together an enthralling story of the legendary West Coast scene from 1977 to 1982 by enlisting the voices of people who were there. The book shares chapter-length tales from the authors along with personal essays from famous (and infamous) players in the scene.
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A love song to the early punk days in LA.
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A Terribly Serious Adventure
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These were among the questions that philosophers wrestled with in mid-twentieth-century Britain, a period shadowed by war and the rise of fascism. In response to these events, thinkers such as Philippa Foot (originator of the famous trolley problem), Isaiah Berlin, Iris Murdoch, Elizabeth Anscombe, Gilbert Ryle, and J. L. Austin aspired to a new level of watchfulness and self-awareness about language as a way of keeping philosophy true to everyday experience.
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Brilliant in every way!
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The Distance Between Us
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In this inspirational and unflinchingly honest memoir, acclaimed author Reyna Grande describes her childhood torn between the United States and Mexico, and shines a light on the experiences, fears, and hopes of those who choose to make the harrowing journey across the border. Reyna Grande vividly brings to life her tumultuous early years in this “compelling...unvarnished, resonant” (BookPage) story of a childhood spent torn between two parents and two countries.
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opened my eyes to the beauty of our stories
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A Childhood
- The Biography of a Place
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- Narrated by: Matt Godfrey
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- Unabridged
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Overall
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Harry Crews grew up as the son of a sharecropper in Georgia at a time when “the rest of the country was just beginning to feel the real hurt of the Great Depression but it had been living in Bacon County for years.” Yet what he conveys in this moving, brutal autobiography of his first six years of life is an elegiac sense of community and roots from a rural South that had rarely been represented in this way.
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Story rings true
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By: Harry Crews, and others
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Hope
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- By: Amanda Berry, Gina DeJesus, Mary Jordan, and others
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- Unabridged
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Overall
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Performance
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Two victims of the infamous Cleveland kidnapper share the story of their abductions, their decade in captivity, and their final, dramatic rescue. On May 6, 2013, Amanda Berry made headlines around the world when she fled a Cleveland area home and called 911, saying: “Help me, I’m Amanda Berry...I’ve been kidnapped, and I’ve been missing for 10 years". A horrifying story rapidly unfolded. Ariel Castro, a local school bus driver, had separately lured Berry, Gina DeJesus, and Michelle Knight to his home, where he kept them chained in the basement.
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A moving read.
- By caroline on 04-28-15
By: Amanda Berry, and others
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Live in Love
- Growing Together Through Life's Changes
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Live in Love is a deeply personal memoir that offers inspiring guidance for anyone looking to keep romance alive, balance children and marriage, express true faith, and live a life of purpose.
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AMAZING!!!
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By: Lauren Akins, and others
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The Ice at the End of the World
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Story
In The Ice at the End of the World, Jon Gertner explains how Greenland has evolved from one of earth’s last frontiers to its largest scientific laboratory. The history of Greenland’s ice begins with the explorers who arrived here at the turn of the 20th century. Their original goal was to conquer Greenland’s seemingly infinite interior. Yet their efforts eventually gave way to scientists who built lonely encampments out on the ice and began drilling - one mile, two miles down.Their aim was to pull up ice cores that could reveal the deepest mysteries of earth’s past.
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Adventure, Science, Advocacy
- By EM Goodkind on 09-08-19
By: Jon Gertner
What listeners say about Breaking Through
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- José
- 01-10-24
Inspiring
Kaitlin's memoirs go beyond her major scientific advances to tell of her search for the unknown and her determination and resilience to find it, even without knowing that doing so would save millions of lives. One of the most inspiring stories I have read, but at the same time it reveals how there is a lot to do to support talent, especially women.
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- Linda Hart
- 11-21-23
Remarkable and inspiring story of grit and perseverance
Remarkable and inspiring story of grit and perseverance. Humanity should be forever grateful. Made me wonder how many researchers, particularly women, who quit before seeing the fruits of their labor because of poor leadership in their labs. The reader's accent created the belief that the book was delivered in the author's voice.
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- Jacob Rios
- 10-29-23
a must listen
this book is a must listen. it’s so inspirational and a lesson for how life should be lived.
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- Amazon Customer
- 11-08-23
Excellent book!
Excellent book! Read it. Wish everyone could read this book. It is a story of grit.
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- Mai Ceesay
- 01-08-24
Phenomenal
Phenomenal and very inspirational. Just wow! Went through several rounds of smiles and cries listening to this book. Thank you for your contribution Dr.!!!
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- Lisa
- 04-06-24
inspiring story
shows how academia works, and how humanity almost missed the contributions of this wonderful scientist.
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- M. Colombo
- 06-02-24
Truly inspiriring
This is an amazing book. Katalin life is truly inspiring. The book it’s well written and well narrated. A Nobel price winner who had to face so many challenges.
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- Stacey
- 08-06-24
Absolutely remarkable!
This is an amazing autobiography by a skilled and determined researcher. She overcame many obstacles to achieve her discoveries and it is fortunate for humanity that she did so, considering how instrumental they were in developing a Covid vaccine. Brava!
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- Josh
- 11-23-24
Love letter to RNA
I enjoyed hearing about this author’s dogged determination in the face of adversity. Her story is inspiring. I admire Katalin Karikó, her voice desperately needs to be heard by the world.
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- Kathleen
- 12-26-23
“This work is not for you, Kati.”
A woman with amazing drive and persistence and a far greater purpose in life than she ever imagined. Perhaps, for the world, it’s just as well she never satisfied Penn State’s dollars per net square footage.
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