Belén Dolores Itzel del Toro wants the normal stuff: to experience love or maybe have a boyfriend or at least just lose her virginity. But nothing is normal in East Oakland. Her father left her family. She’s at risk of not graduating. And Leti, her super-Catholic, nerdy-ass best friend, is pregnant—by the boyfriend she hasn’t told her parents about, because he’s Black, and her parents are racist.

On the night Miles Abernathy—sixteen-year-old socialist and proud West Virginian—comes out as trans to his parents, he sneaks off to a party, carrying evidence that may finally turn the tide of the blood feud plaguing Twist Creek: Photos that prove the county’s Sheriff Davies was responsible for the so-called “accident” that injured his dad, killed others, and crushed their grassroots efforts to unseat him. The feud began a hundred years ago when Miles’s great-great-grandfather, Saint Abernathy, incited a miners’ rebellion that ended with a public execution at the hands of law enforcement.

Magdalena Herrera is about to graduate high school, but she already feels like an adult with serious responsibilities: caring for her ailing grandmother; working a part-time job; clandestine makeouts with a girl who has a boyfriend. And then there's her secret, which pulls her into the basement each night, drains her of energy, and leaves her bleeding. A secret that could hurt and even kill if it ever got out—like it did once before.

Dolores Mendoza is not thriving. She was recently diagnosed with a chronic bladder condition called interstitial cystitis. The painful disease isn’t life-threatening, but it is threatening to ruin her life. Just when things seem hopeless, Dolores meets someone poised to change her fate. Terpsichore Berkenbosch-Jones is glamorous, autistic, and homeschooled against her will by her overprotective mother. After a rocky start, the girls form a tentative partnership

Ever since cancer invaded his adoptive mother’s life, Brett feels like he’s losing everything, most of all control. To cope, Brett fuels all of his anxieties into epic fantasies, including his intergalactic Kid Condor comic book series, which features food constellations and characters not unlike those in his own life. But lately Brett’s grip on reality has started to lose its hold. The fictions he’s been telling himself—about his unattractive body, the feeling that he’s a burden to his best friend, that he’s too messed up to be loved—have consumed him completely.

Ever since the world filled with portals to hell and bloodthirsty demons started popping out on the reg, Jasper’s life has gotten worse and worse. A teenage nobody with no friends or family, he is plagued by the life he can’t remember and the person he’s sure he’s supposed to be. Jasper spends his days working as a checkout clerk at the Here for You discount mart, where a hell portal in aisle nine means danger every shift. But at least here he can be near the girl he’s crushing on—Kyle Kuan, a junior member of the monster-fighting Vanguard.

When Jo-Lynn Kirby ‘s former best friend—pretty, nice Maddie Price—comes to her claiming to be in trouble, Jo assumes it's some kind of joke. After all, Jo has been an outcast ever since her nude photos were leaked—and since everyone decided she deserved it. There’s no way Maddie would actually come to her for help. But then Maddie is gone. As Jo digs deeper into Maddie’s disappearance, she’s left to wonder who she’s really searching for: Maddie, or the girl she used to be.

After being placed in foster care, Rhi is hungry for a fresh start and begins working at the Happy Valley Wildlife Preserve. While in the woods, she stumbles upon a surreal sight: a pack of wolves guarding four feral and majestic girls. After Rhi gains their trust, they reveal that they’re princesses from another land, raised by a magical prophet they call Mother—and they're convinced Rhi is their lost fifth sister. Unsure what to believe, Rhi ushers the girls to civilization, where they’re met with societal uproar and scrutiny, dubbed “The Wild Girls of Happy Valley.”

As the contentious 2017 presidential election looms and protests rage across every corner of the city, life in Tegucigalpa, Honduras, churns louder and faster. For her part, high school senior Libertad (Libi) Morazán takes heart in writing political poetry for her anonymous Instagram account and a budding romance with someone new. But things come to a head when Mami sees texts on her phone mentioning a kiss with a girl and Libi discovers her beloved older brother, Maynor, playing a major role in the protests.

Medea, daughter of King Aeetes of Colchis, longs for a different life. Since childhood, she has been separated from her sister, shunned by her mother, and beaten and tormented by her brother and father. All because Medea was born with a unique and seemingly dangerous talent: witchcraft. But when a dashing young hero, Jason, arrives to claim the famed Golden Fleece that her father fiercely protects, Medea sees her opportunity for escape.