Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.

Jim Geraghty has been a passionate participant in the orphan drug revolution since its inception―a leader in the field as a strategy consultant, biotechnology executive, and venture entrepreneur. His book is in part a history, with eyewitness accounts of advances as they occurred and portraits of the pioneering scientists and physicians, tireless activists, and visionary business leaders who made the revolution happen. And it tells deeply personal stories of patients and parents willing to risk untried new therapies.

In Artificial Intelligence, Mitchell turns to the most urgent questions concerning AI today: How intelligent - really - are the best AI programs? How do they work? What can they actually do, and when do they fail? How humanlike do we expect them to become, and how soon do we need to worry about them surpassing us? Along the way, she introduces the dominant methods of modern AI and machine learning, describing cutting-edge AI programs, their human inventors, and the historical lines of thought that led to recent achievements.

Lee, the founding father of modern Singapore and its prime minister from 1959 to 1990, has honed his wisdom during more than fifty years on the world stage. Almost single-handedly responsible for transforming Singapore into a Western-style economic success, he offers a unique perspective on the geopolitics of East and West. American presidents from Richard Nixon to Barack Obama have welcomed him to the White House.

In the years following her role as the lead author of the international best seller, Limits to Growth - the first book to show the consequences of unchecked growth on a finite planet - Donella Meadows remained a pioneer of environmental and social analysis until her untimely death in 2001. Thinking in Systems is a concise and crucial book offering insight for problem-solving on scales ranging from the personal to the global. Edited by the Sustainability Institute's Diana Wright, this essential primer brings systems thinking out of the realm of computers and equations and into the tangible world....

It’s the flight before Christmas and Molly just got an unexpected gift: a free first-class upgrade on her plane trip home for the holidays. Bring on the complimentary cocktails! But after one too many, she spills all her secrets to the hot guy seated next to her—only to wake up mortified when her buzz has worn off. At least she never has to see Liam again ... or so she thinks. When Molly arrives at Christmas House, the festive rental home that she and her family are sharing with her sister’s fiancé and his wealthy family, she discovers that Liam is one of the new in-laws. Oops.

Sydney Shaw, like every single woman in New York, has terrible luck with dating. She’s seen it all: men who lie in their dating profile, men who stick her with the dinner bill, and worst of all, men who can't shut up about their mothers. But finally, she hits the jackpot. Her new boyfriend is utterly perfect. He's charming, handsome, and works as a doctor at a local hospital. Sydney is swept off her feet. Then the brutal murder of a young woman—the latest in a string of deaths across the coast—confounds police. The primary suspect? A mystery man who dates his victims before he kills them.

Living in a year around Christmas town has its drawbacks. The caroling, the decorations, the insanely cheery spirit, it never disappears. It's why I like to hibernate away in my cave - I mean housekeeping a healthy distance from the holly jolly spirits. And all was going according to plan until my nemesis, Storee Taylor, moved in next door to care for her Aunt Cindy. Without blinking, she turned my simple world into a real nightmare-before-Christmas, especially when she decided to enter the town Christmas Kringle contest - which she was determined to win.

When the enslaved Jim overhears that he is about to be sold to a man in New Orleans, separated from his wife and daughter forever, he decides to hide on nearby Jackson Island until he can formulate a plan. Meanwhile, Huck Finn has faked his own death to escape his violent father, recently returned to town. As all readers of American literature know, thus begins the dangerous and transcendent journey by raft down the Mississippi River toward the elusive and too-often-unreliable promise of the Free States and beyond.

No matter your goals, Atomic Habits offers a proven framework for improving - every day. James Clear, one of the world's leading experts on habit formation, reveals practical strategies that will teach you exactly how to form good habits, break bad ones, and master the tiny behaviors that lead to remarkable results. If you're having trouble changing your habits, the problem isn't you. The problem is your system. Bad habits repeat themselves again and again not because you don't want to change, but because you have the wrong system for change.