Before the sun rose over the town of Sisterville, everything went black. A natural disaster of unknown origins takes the lives of every living creature and decimates the small town. Disgraced NASA scientist and now Cleveland weatherman Hero Galanis knows he is more than a local celebrity on television. He recognizes the anomaly on the satellite image as a repeat of the event that cost him his career. Decades earlier, Hero made predictions about the devastation the anomaly would cause, but those predictions pale in comparison to the reality the world currently faces.

Somewhere out there exists an extinction level virus so powerful there is nothing that can stop it. In a misguided attempt to avert the future deadly threat, biologist Elias Marcum creates his own impervious virus. His arrogance in his work inadvertently causes the accidental release of the virus. By the time it is discovered, it is too late.

A mysterious growth covers three deer on Miller Run Road outside of Griffin, Arizona. The sickly animals are mistaken for scared until they brazenly attack a car, causing a fatal accident. Like everyone else in town, Cass “Scoop” McDaniels has lived in Griffin her entire life. When she is assigned the accident story, her findings are dismissed. The story dies with the people on the road. But Cass doesn’t give up.

A debilitating virus emerges in India and quickly burns its way through the densely populated areas of Asia. The victims suffer for days even weeks on end until finally succumbing. Streets are empty and major cities are mere graveyards. Because of the slow killing nature of the virus, attempts to contain it to one continent seemingly work at first, but human smuggling into infection-free areas cause the virus to break borders globally.

When the news of an impending extinction-level meteor impact is made public, humanity struggles to find some way to survive. Violet journals her life in a notebook in the form of letters to her grandmother. They start out sarcastic and funny, as she shares entertaining and exaggerated tales of her teenage life. But when Violet finds out about the meteor, everything changes. Suddenly she is thrust into a grown-up world, and her survival isn't guaranteed.

In a small pocket of the world the sickness has been in existence since the sixties. A disease so feral, it strikes eighty percent of all children under the age of fifteen. For decades it has pushed the boundaries into three countries. Those infected become mere shells, often in a state followed by violent tantrums. There is no hope, no treatment, and there is no cure. Little is known about the sickness called the Nodding Disease. Information regarding it is often buried deep.

In a small Montana town, it takes four minutes for every man, woman, and child to die. It isn’t a virus or biological attack, but rather the beginning of a geological event that triggers a chain reaction across the globe with devastating effects. A repeat of an extinction event that occurred millions of years earlier. There is no stopping it. The only way to survive is to stay ahead of it. Tom Foster hasn’t flown in decades, yet, he sets his fear aside for a vacation with his grown sons.

Following a distress call from the state police, Dr. Edward Neil and his team from the Centers for Disease Control enter the small town of Hartworth, Montana. Immediately they encounter a man in a pickup truck holding a quarantine post, his body decimated by a disease like they have never seen. The entire town, population a little under 1000... dead. Men, women and children. The unknown germ hit so fast, the town did not stand a chance of survival.

What starts as an emergence of a new virus quickly turns into Mother Nature’s ultimate population control. While attending a seminar at the Ambassador Hotel, Ava Mason is unknowingly exposed to a carrier of a highly contagious virus. The next morning, she wakes to a steady pounding on her door. Within minutes, her home is stormed and she and her three children are apprehended, placed in a van and taken away. They are told nothing. No one is. Ava, her children, and others are brought to the Ambassador and sealed in.

In the midst of a bitter family feud, the much divided Rolland family is thrown together when news of their father's untimely passing places them on a red-eye flight from Seattle to Washington D.C. Although, they are physically close in the tight space of the aircraft, Rege, Mark, and Kit are at their farthest distance apart emotionally. Until the unthinkable happens. Two hours into the flight, missiles streak across the star-filled sky, the detonation of a nuclear warhead causes the plane to make a forced landing.

In a bid to repair the relationship with her son, Audrey Fields plans a getaway for the two of them at a remote, off-the-grid campsite. No electricity, no phones, no distractions. When things don’t go as planned, Audrey begins her journey home, only to make the horrifying discovery that 90 percent of the population has suddenly died. Whatever happened sent cars spiraling out of control and planes falling from the sky. Alone and separated from her family, Audrey is soon joined by two other survivors. Their trek across Virginia is a nothing less than walking through a minefield.

It is a very rare occasion that Abby Miller travels into the city, but an errand that can only be done in town prompts her to make it a girls' day out with her two daughters. Unfortunately, the day is far from perfect and they are in the worst place possible when nuclear war strikes... ground zero.

When Leah and Calvin found out they were expecting, they were over the moon. That day would be one to remember forever… but for more reasons than one. That was the day the world changed. That was the day joy turned to fear. A deadly virus broke out, with many of those infected becoming violent and uncontrollable. And it was spreading fast. Realizing they are no longer safe in their own home, they make a break out of the city to find sanctuary. But when Leah is bitten, Calvin faces the unimaginable struggle of having to take care of their newborn alone. Traveling with the baby and his dead wife in tow, he comes across Hannah, a young girl who lost her family to the virus. They make their way across country together, meeting others trying to find their own sanctuary. They eventually find safety but Calvin soon realizes all is not as it seems and he must make an agonizing choice.

For the first time since his divorce, CJ will be able to take his son on a vacation. Along with his father, they make it a guys’ trip to the west coast. Little do they know their trip that is intended to be a lifetime of memories would include facing insurmountable odds. The lack of warning leaves everyone in the dark about what has occurred and vulnerable to all that unfolds. It doesn’t stop with the meteors. The disastrous events come one after another, a domino effect of annihilation.

Judd Bryant, a survivor who does not succumb to the horrendous death, is a talented man with a zest for living. He faces his darkest hour until he finds a purpose in the form of Dawson, an eight-year-old boy with an unusual gift.The unlikely pair set out to find others, only to realize that each passing day is increasingly more dangerous than the one before. Their road becomes an obstacle course filled with unimaginable disasters.