What starts as an emergence of a new virus quickly turns into Mother Nature’s ultimate population control. While attending a seminar at the Ambassador Hotel, Ava Mason is unknowingly exposed to a carrier of a highly contagious virus. The next morning, she wakes to a steady pounding on her door. Within minutes, her home is stormed and she and her three children are apprehended, placed in a van and taken away. They are told nothing. No one is. Ava, her children, and others are brought to the Ambassador and sealed in.

It is a very rare occasion that Abby Miller travels into the city, but an errand that can only be done in town prompts her to make it a girls' day out with her two daughters. Unfortunately, the day is far from perfect and they are in the worst place possible when nuclear war strikes... ground zero.

It happens on a routine red-eye from Las Vegas to New York. Just as the plane breaks the early morning sky, in a blink of an eye, 144 passengers onboard flight 6520 die. There is no rhyme or reason. Experts scramble to find an explanation on how and why those on Flight 6520 met their demise so quickly and violently. It is hurriedly explained as a terror attack to the public, but General Buford Cane knows better. He has spent his entire career dedicated to the investigation and prevention of globe-threatening events.

When Leah and Calvin found out they were expecting, they were over the moon. That day would be one to remember forever… but for more reasons than one. That was the day the world changed. That was the day joy turned to fear. A deadly virus broke out, with many of those infected becoming violent and uncontrollable. And it was spreading fast. Realizing they are no longer safe in their own home, they make a break out of the city to find sanctuary. But when Leah is bitten, Calvin faces the unimaginable struggle of having to take care of their newborn alone. Traveling with the baby and his dead wife in tow, he comes across Hannah, a young girl who lost her family to the virus. They make their way across country together, meeting others trying to find their own sanctuary. They eventually find safety but Calvin soon realizes all is not as it seems and he must make an agonizing choice.

Judd Bryant, a survivor who does not succumb to the horrendous death, is a talented man with a zest for living. He faces his darkest hour until he finds a purpose in the form of Dawson, an eight-year-old boy with an unusual gift.The unlikely pair set out to find others, only to realize that each passing day is increasingly more dangerous than the one before. Their road becomes an obstacle course filled with unimaginable disasters.