St Angelus runs like a family: the workers take care of their own - a lesson the mysterious new assistant matron, Miss Van Gilder, is about to learn the hard way. Little Joe has had trouble breathing but the doctors don’t take his sister Lily’s concerns seriously, least of all Miss Van Gilder. The nurses of Lovely Lane have a secret which is dividing their close knit group and when Nurse Pammy Tanner once again breaks the rules, her actions threaten them all.

In postwar Tarabeg, two women are waiting for ambitious Michael Malone to return home. Rosie is the local schoolteacher, and most people think she is promised to him. Just a few have guessed that he has secretly begun to woo Sarah, whose brutal fisherman father would kill her if he knew. Both Rosie and Sarah love Michael, both hope to become his wife and their lives will interweave in a tale of tangled secrets, old promises and new feuds. Michael Malone's choice will have fateful consequences for everyone - especially, in due course, for his young daughter....

Lady Joanna Harcourt and her daughter, Sarah, discover their life of luxury at Goodwill House is over. Because with Lord Harcourt away fighting, the Harcourt girls are facing financial ruin. Lady Joanna is terrified of losing their home, but for Sarah, this means her dreams of becoming a doctor are over. Headstrong Sarah isn’t one to quit! War or not, she’s determined to find a way to save her home and follow her dreams - whatever it takes.

As war looms in Europe, 18-year-old Jane Shaw runs the household as an unpaid servant on a meagre budget. When tragedy strikes and she loses her beloved younger brother in suspicious circumstances, Jane takes a position in service looking after Ned, a troubled young boy. Here she meets dashing David Heron, Ned's Uncle and they form an immediate attachment until she is dismissed after being accused of stealing a piece of jewellery. Returning home, Jane and her sister, Melia, are soon orphaned and left at the mercy of their Aunt Alice.

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

1941. The Blitz rages over London. And even in Cornwall, the war is being fought. When Violet loses her sister in the Blitz, she must take her nieces to safety in Cornwall. On the coast, she meets carefree chorus girl Eva, who is also running from the dangers of London. But Porthcurno hides a secret military base, and soon Violet and Eva realise there’s a battle to fight in Cornwall, too. Together with local Hazel, who works on the base, they must come together to help the war effort. But will their friendship be enough to keep them safe?

1904: Ellen Copley is still a child when she leaves behind the sooty rail yards of Glasgow and crosses the Atlantic Ocean with a heart full of dreams. Yet within weeks of their arrival in America, her father has disappeared - leaving Ellen with resentful relatives, feeling alone and scared for her future. But then her kind Aunt Rose invites Ellen to stay with her large family in their rambling house on beautiful Amherst Island, which nestles like a jewel in the blue waters of Lake Ontario.

When Ellie and her family move to a tiny village in rural Wales, it’s meant to be a new beginning for all of them. They have decided to take over her husband’s family inn, leaving behind their old life and troubles in America.

The war has ended; the men are returning home to their loved ones, but for some, things have changed. Charlotte Hennessey-White's husband, David, is no longer the gentle loving man he once was and Charlotte, so independent during the war, is devastated. Edna Burbage's strong fiancée, Colin, has suffered appalling physical injuries. He won’t hold her to her promise of marriage, but she insists her feelings are unchanged. But is that true? And Polly Chandler's sweetheart, Gavin, who’d she’d planned her whole future around, hasn’t come home at all.

Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

Rita and Rosie Stevens are only nine and five years old when their widowed mother marries a violent bully called Jimmy Randall and has a baby boy by him. Under pressure from her new husband, she is persuaded to send the girls to an orphanage, not knowing that the papers she has signed will entitle them to do what they like with the children. And it is not long before the powers that be decide to send a consignment of orphans to their sister institution in Australia. Among them - without their family's consent or knowledge - are Rita and Rosie.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds.

How far would you go to protect your family? Single dad Ben is doing his best to raise his children, with the help of his devoted mother, Judi. And then Ben meets Amber. Everyone thinks this is a perfect match for Ben, but Judi isn't so sure.... There's just something about Amber that doesn't add up. Ben can't see why his mother dislikes his new girlfriend. And Amber doesn't want Judi anywhere near her new family. Amber just wants Ben and the children.

Liverpool, 1941. Troubled by a dark family history and the pain of seeing her country torn apart by war, young June Lavender finds new hope when she takes a job at the Dr Barnardo's children's home. There she meets Lizzie McRae, a little girl who is the spitting image of June's sister, who died tragically years before. Against the matron's wishes, the two girls form an unexpected bond as June tries to get the traumatised orphan to speak.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Liverpool, 1940. When her childhood sweetheart, Johnny, is killed in action, Maxine Grey loses more than her husband - she loses her best friend. Desperate to make a difference in this awful war, Maxine takes a nursing job at London’s St Thomas’ hospital. She takes comfort in the attentions of a handsome surgeon, but Edwin Blake isn’t all he seems. And as the Blitz descends on the capital, Maxine faces more heartache. When she returns to Liverpool, she harbours a secret.

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

In 1964, Maggie wakes to find herself in a mental asylum, with no idea who she is or how she got there. Remnants of memories swirl in her mind - a familiar song, a storm, a moment of violence. Slowly, she begins to piece together the past and the events which brought her to this point.

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

A long-forgotten secret, a scandalous attraction and a place where two women's lives are changed forever. 1926: Violet Armstrong is one of the few remaining members of staff working at the grand Evergreen Spa Hotel as it closes down over winter. Only a handful of guests are left, including the heir to a rich grazing family, his sister and her suave suitor. When a snowstorm moves in, the hotel is cut off and they are all trapped. No-one could have predicted what would unfold.

East London, 1888 - a city apart. A place of shadow and light where thieves, whores, and dreamers mingle, where children play in the cobbled streets by day and a killer stalks at night, where bright hopes meet the darkest truths. Here, by the whispering waters of the Thames, Fiona Finnegan, a worker in a tea factory, hopes to own a shop one day, together with her lifelong love, Joe Bristow, a costermonger's son. With nothing but their faith in each other to spur them on, Fiona and Joe struggle, save, and sacrifice to achieve their dreams.

Carly and Rob, Jenni and Craig. Two couples, four friends. Betraying each other. Wanting each other. All of them have access to prescription drugs through the medical practice where they work, and all of them are fighting their own demons. But can any of them be trusted? And when the lies begin, can they ever be silenced?

After four years as a military nurse, Charlotte Brown is ready to leave behind the devastation of the Great War. The daughter of a vicar, she has always been determined to dedicate her life to helping others. Moving to busy Liverpool, she throws herself into her work with those most in need, only tearing herself away for the lively dinners she enjoys with the women at her boardinghouse.

They're calling it the worst pileup in London history. Margaret Holloway is driving home, but her mind is elsewhere - on a troubled student, her daughter's acting class, the next day's meeting - when she's rear-ended and trapped in the wreckage. Just as she begins to panic, a disfigured stranger pulls her from the car seconds before it's engulfed in flames. Then he simply disappears.

Catherine Carlisle is trapped in a loveless marriage, and the threat of World War Two is looming. She sees no way out...that is until a trusted friend asks her to switch her husband’s papers in a desperate bid to confuse the Germans. Soon Catherine finds herself caught up in a deadly mixture of espionage and murder. Someone is selling secrets to the other side, and the evidence seems to point right at her.

When a mysterious note arrives for six months pregnant Dr Eliana Hughes, she begins to doubt every aspect of her life - from her mixed feelings about motherhood to her marriage to Martin, who has become distant in recent months. As the person behind the note escalates their campaign to out Eli’s husband as a cheat, she finds herself unable to trust even her own instincts, and as pressure builds, she makes a mistake that jeopardises her entire future. Elsewhere, someone is watching.

Current day, Oxford, England. Young American scholar Kendra Van Zant, eager to pursue her vision of a perfect life, interviews Isabel McFarland just when the elderly woman is ready to give up secrets about the war that she has kept for decades...beginning with who she really is. What Kendra receives from Isabel is both a gift and a burden--one that will test her convictions and her heart.