Bristol 1936. Jenny Crawford has resigned herself to a loveless marriage living hand to mouth with their two children. Like many others, husband Roy struggles to find work at the docks but a chance encounter turns the family's fortunes around. Not only does he get regular work but they are also allocated a council house on Coronation Close on the outskirts of the city. Jenny and the children are overjoyed, this is the fresh start she could only ever dream of. But trouble feels never too far away.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Cassandra Hale grew up knowing little about her parentage, and she had made peace with the fact that she never would. But her world shifts when a shocking deathbed confession reveals a two-year-old letter from Mr. Clark, the master of Briarton Park, with hints to her family's identity. Stung by betrayal, Cassandra travels to the village of Anston only to learn Mr. Clark has since passed away.

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

Clara Newton is the new Housemother of Shilling Grange Orphanage. Many of the children have been bombed out of their homes and left without families, their lives torn apart by the war, just like Clara’s. Devastated by the loss of her fiancé, a brave American pilot, she is just looking for a place to start again. But the orphans are in desperate need of her help.

The war has ended; the men are returning home to their loved ones, but for some, things have changed. Charlotte Hennessey-White's husband, David, is no longer the gentle loving man he once was and Charlotte, so independent during the war, is devastated. Edna Burbage's strong fiancée, Colin, has suffered appalling physical injuries. He won’t hold her to her promise of marriage, but she insists her feelings are unchanged. But is that true? And Polly Chandler's sweetheart, Gavin, who’d she’d planned her whole future around, hasn’t come home at all.

Rita and Rosie Stevens are only nine and five years old when their widowed mother marries a violent bully called Jimmy Randall and has a baby boy by him. Under pressure from her new husband, she is persuaded to send the girls to an orphanage, not knowing that the papers she has signed will entitle them to do what they like with the children. And it is not long before the powers that be decide to send a consignment of orphans to their sister institution in Australia. Among them - without their family's consent or knowledge - are Rita and Rosie.

Sunderland, 1940, and the women go to the shipyards to do their bit for the war effort. Polly never dreamed she would be able to work in the shipyards like the men in her family but times are tough and her new job ends up giving her more than she ever expected when she meets enigmatic dock diver Tommy Watts. During the day, head welder Rosie teaches her fledgling flock of trainees their new trade, but at night she hides a secret life. And mother hen Gloria signs up to escape her brutal husband, but finds she cannot run....

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.