You survived Bug Wars I–IV. But can you apply it?

This episode is the exam-mode gauntlet: 8 board-style questions across antimicrobial mechanisms, PK/PD principles, combo logic, and sterilization.

🎯 Format:

• Multiple-choice questions
• Pause to answer
• Detailed breakdown of correct and incorrect choices
• Flashcard recap at the end

💡 Topics include:

• Time- vs. concentration-dependent kill
• MIC vs. MPC vs. PAE
• Static + cidal combo pitfalls
• Sporicidal agents & antiseptic limitations
• Enantiomers, fat solubility, and sighthound drug metabolism

Built to reinforce the essentials from the full Bug Wars arc.
Rapid-fire. High-yield. Board-focused.

🎧 Built for surgical residents.
Feedback or requests? Carl Damiani (cd@simini.com)

You scrubbed the skin. You soaked the instruments. You wiped the table.
But the bugs came back — because you picked the wrong weapon.

In this episode, we tackle the external battlefield of infection control:
the difference between disinfectants, antiseptics, and sterilants — and what actually kills.

🔍 You’ll learn:

• Why some products are safe on skin… and others destroy tissue
• Which agents kill spores (and which leave them behind)
• The real reason chlorhex sticks around — and why povidone-iodine doesn’t
• What makes hydrogen peroxide bubble (and why that means nothing)
• Sterilization benchmarks, toxicity traps, and board-level questions

🎯 Includes a board-style question + flashcard-style recap.

🎧 Built for surgical residents.
Feedback or requests? Carl Damiani (cd@simini.com)

You added a second antibiotic to play it safe… and sabotaged your treatment.

In this episode, we unpack why combining antimicrobials can be a powerful strategy — or a clinical disaster.

🔍 You’ll learn:

• The difference between synergy, additive effects, and antagonism
• Why static + cidal combos can cancel each other out
• Which combinations actually work (and why)
• When to combine, when to de-escalate, and when to walk away
• Toxicity overlap, PK/PD interactions, and board-level traps to avoid

💡 Includes a board-style question + flashcard-style recap.

🎧 Built for surgical residents.
Feedback or requests? Carl Damiani (cd@simini.com)

The drug was right. The culture said susceptible.
But the patient didn’t improve.

In this episode, we reveal the real reason antimicrobial therapy fails:
You didn’t match the drug’s kill style to the dosing strategy.

🔍 Learn:

• The difference between time-dependent and concentration-dependent killing
• Key PK/PD metrics like Time > MIC, Cmax/MIC, and AUC/MIC
• Why some antibiotics demand frequent small doses while others want big hits
• How drug class, site of infection, and patient physiology change your strategy
• Common pitfalls that lead to treatment failure or resistance

🎯 Includes a board-style question and flashcard-style recap.

🎧 Built for surgical residents.
Feedback or requests? Carl Damiani (cd@simini.com)

You picked the right drug. The culture said susceptible.
And the infection still got worse.

It’s not always resistance — sometimes, it’s you.

In this episode, we break down how antimicrobials actually kill — and why understanding that is the key to board success and clinical results.

You’ll learn:

• The difference between bactericidal and bacteriostatic drugs
• The mechanisms of action for the major antimicrobial classes
• Why folic acid synthesis inhibition is a double-drug strategy
• How to choose the right kill style for the right patient
• Time-dependent vs. concentration-dependent antibiotics

Includes a board-style question + flashcard-style recap.

🎧 Built for surgical residents.
Feedback or requests? cd@simini.com

In this episode, we break down one of the most misunderstood principles in fracture repair: what role your implant is actually playing.

Is it carrying all the load? Or sharing it with the bone?
Because if you mismatch your construct to the fracture — it’s not if it will fail. It’s when.

🔍 You’ll learn:

• The difference between load sharing and load bearing
• What happens when implants are too stiff or too weak
• When to use bridging vs. compression
• Why implant selection = healing environment
• Common board traps, like over-stiff constructs and stress shielding

Includes a board-style question + flashcard recap. Built for residents.

🎧 Listen while commuting, scrubbing in, or running with your dog.

Feedback? Ideas for the next episode? cd@simini.com

What actually heals a fracture — the metal or the biology? In this episode, we break down the real mechanics of bone healing, and why even textbook-perfect plates can fail if the strain environment isn’t right.

You’ll learn:

• The difference between primary and secondary bone healing
• Why interfragmentary strain (IFS) controls tissue differentiation
• How to match fixation strategy to fracture type
• What constructs fail and why — and how to avoid it

Includes a board-style question, a flashcard recap, and a few “don’t make this mistake” moments.

🎧 Built for surgical residents. Backed by Tobias.
🔍 Powered by Simini + AI, fine-tuned for board prep.

🚨 Feedback? Ideas for the next episode? Email cd@simini.com

What’s the real difference between tension, shear, and torsion — and why does it matter in fracture repair?

In this high-yield kickoff episode, we break down the five forces that rule orthopedic surgery:

• Tension
• Compression
• Shear
• Bending
• Torsion

You’ll learn:

• How each force works (with simple analogies you won’t forget)
• Why implants fail — and how to choose the right one
• How to spot board-style traps related to fixation
• And a rapid-fire recap to lock it all in

Built for small animal surgery residents prepping for boards, this episode delivers fast clarity, zero fluff, and real surgical relevance.

📍 If you’ve ever confused compression with shear under stress, this one’s for you.