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00:52 Intro (shoutuout to the BSH anticoagulant monitoring guidelines)

02:15 Practical relevance of testing and monitoring anticoagulants

07:30 Heparin: The Basics

09:00 Unfractionated Heparin vs. Low Molecular Weight Heparin

10:24 Mechanism of action of Heparin (UfH vs. LMWH)

• LMWH: more Anti-Xa activity
• UfH Anti-IIa acitivity = Anti-Xa activity

15:30 Pharmacokinetic differences (UfH vs. LMWH)

23:28 Unfractionated Heparin uses and monitoring

34:34 Anti Xa Assay

42:32 Activated Clotting Time (POCT)

46:56 Anti Xa in LMWH: Practical considerations

52:03 LMWH uses and dosing

55:30 Summary

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

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00:54 Intro and table of contents

1:48 Case 1: pre-op, prolonged PT and ++ prolonged APTT…thrombin time done

03:44 Case 2: post-op, normal PT and prolonged APTT…thrombin time done

04:46 Thrombin Time definition and ingredients (its all about the fibrinogen!)

10:45 Differentiating causes of prolonged thrombin time- protamine, reptilase, ecarin

17:24 Case 3: Major Haemorrhage (Variceal), due OGD, Derived PT Fibrinogen normal

20:45 Clauss Fibrinogen- methodology, causes of change and treatment of deranged fibrinogen

30:09 Derived PT Fibringoen

31:20 ELISA, TEG and ROTEM (brief)

33:07 Summary

36:56 David’s request (email us your questions!)

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

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0:52 Intro and table of contents

2:36 CASE 1- Infection, due surgery and a prolonged APTT ft. a refresher on APTT prolongation

08:00 Mixing studies- definition and uses ft. Hari’s exam nugget

17:00 Factor assays (1 stage, 2 stage and chromogenic assays) ft. David’s humorous humility

43:30 David applies his new-found knowledge to our first case

45:45 CASE 2- Infection, hx of weight loss and bleeding and a prolonged APTT

47:36 Summary

https://practical-haemostasis.com/Factor%20Assays/1_stage_pt_factor_assay.html

https://practical-haemostasis.com/Factor%20Assays/chromogenic_factor_assays.html

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

Send us your feedback!

Feedback

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

Send us your feedback!

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00:00 Intro

04:25 Automated Methods of Measuring a Clot

05:50 Scenario 1 & Pre-Analytical Variables

11:50 HIL Index & Patient Factors

15:55 Blood Tube Basics

21:10 Nitty Gritties- What Happens When We Send a PT?

23:20 PT vs INR for Warfarin- Going Down The Rabbit Hole...

26:35 Heparin Neutralising Buffer

29:00 APTT

33:05 Summary (& an honorable mention)

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

Send us your feedback!

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0:00 Intro

2:45 What is Haemostasis?

3:55 Stages of Haemostasis (summary)

4:45 Primary Haemostasis

8:35 Secondary Haemostasis

11:10 The Clotting Cascade

12:20 Common + Extrinsic Pathway

13:50 Intrinsic Pathway (TwelvEleveNinEight)

14:25 Clotting Tests

16:30 Hari Pops The Bubble

18:05 In-Vivo vs. In-Vitro

22:20 Isolated PT Prolongation- causes

25:46 Isolated APTT Prolongation- causes

27:43 Paired PT/APTT Prolongation- causes

28:50 Best Test for Bleeeding (David makes Hari proud)

30:24 Bleeding History Pearls and Questionnaires

33:55 When The PT/APTT Screen Doesn't Work

37:25 NICE Guidelines Reference for Surgery

38:15 David's Scenarios

42:00 Summary

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

Send us your feedback!

Feedback

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

Send us your feedback!

Feedback

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

Email: basicstobrilliancehaem@gmail.com

Insta: BasicstoBrilliance

X: @basics_2_brill

Send us your feedback!