The Science Of

By: Cloudcast
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  • Summary

  • Where science curiosity meets the amazing scientists of UCSD!

    Welcome to "The Science Of"!!!
    Copyright Cloudcast
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Episodes
  • Episode 20 | The Science Of Microbes | Dr. David J. Gonzalez, Associate Professor Skaggs School of Pharmacy / Department of Pharmacology

    Episode 20 | The Science Of Microbes | Dr. David J. Gonzalez, Associate Professor Skaggs School of Pharmacy / Department of Pharmacology
    Dec 30 2024
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich from the UCSD Moores Cancer Center sit down to discuss THE SCIENCE OF MICROBES with Dr. David Gonzalez, an Associate Professor in Pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, School of Medicine, as the Founder and Director for the Collaborative Center of Multiplexing Proteomics. Dr. Gonzalez was on this episode joined by his sons, David Jr. and Isaiah, and a lab researcher, Yesenia, an alumna of UC-Riverside. They discuss the importance of microbes, their roles in human health, and the impact of antibiotics on gut microbiomes. They highlight the potential of proteomics in understanding protein interactions and the need for alternative therapeutics. The conversation also touches on the personal and professional journeys of the participants, emphasizing the importance of education and perseverance in scientific careers.Enjoy this episode and get your PODucation on!! "Rapid Fire" Warm-Up Round and Personal IntroductionsThe guests participate in a rapid-fire warm-up round, answering questions about their first science experiments and favorite musicians.Dr. Gonzalez shares his first science experiment involving making plastic in a chemistry class, which sparked his interest in science.Isaiah, David Jr. and Yesenia share their first experiences with science projects The guests discuss their favorite musicians, with from Tame Impala to Kendrick LamarMicrobes and Their ImportanceDr. Gonzalez explains the role of microbes as the gatekeepers of the world, contributing to oxygen production and metabolism in the gut.The conversation touches on the balance between good and bad microbes, with Dr. Gonzalez emphasizing that microbes can be both beneficial and harmful depending on context.The guests discuss the importance of the gut microbiome and its impact on human health, including the role of stool samples in microbiome research.Dr. Gonzalez highlights the advancements in microbiome research at UCSD and the importance of understanding the microbiome for future medical treatments.Applications of Microbiome ResearchThe guests discuss the potential of the gut microbiome in treating diseases and the role of probiotics and antibiotics in maintaining gut health.Dr. Gonzalez mentions the impact of antibiotics on the gut microbiome and the rise of antibiotic-resistant pathogens.The conversation shifts to the role of the microbiome in cancer treatment and the potential of immunotherapies.Dr. Gonzalez shares insights on the use of checkpoint inhibitors and the microbiome's influence on treatment efficacy.Antibacterial and Antimicrobial IndustryThe guests address the challenges of antibacterial and antimicrobial products, emphasizing the need for awareness of antibiotic resistance.Dr. Gonzalez discusses the overuse of antibiotics and the importance of finding alternative therapeutic approaches, such as vaccines.The conversation highlights the role of proteomics in understanding the proteome and its applications in medical research.Dr. Gonzalez explains the power of proteomics in providing a comprehensive view of protein interactions and its potential in developing new drugs.Impact of COVID-19 on Scientific CareersThe guests share their personal experiences and the impact of COVID-19 on their scientific careers and educational paths.Isaiah discusses the challenges of gaining clinical experience during the pandemic and the importance of community outreach and education.David Jr. shares how COVID-19 led him to pursue a PhD in structural biology, focusing on emerging viruses.The guests emphasize the importance of resilience and adaptability in navigating career challenges during the pandemic.Future of Microbiome Research and Personal ReflectionsThe guests discuss their hopes for the future of microbiome research, including the development of alternative therapeutics and the continued advancements in proteomics.Dr. Gonzalez envisions a future where real-time health monitoring is possible through stool analysis.The guests reflect on the importance of education and mentorship in fostering scientific careers and the impact of their work on future generations.The conversation concludes with the guests sharing their admiration for each other and their commitment to continuing their scientific pursuits.Be sure to subscribe to and share "The Science Of" with all of your friends. We appreciate your support."The Science Of" podcast series is brought to you by the UCSD Moores Cancer Center, SchoolCAST, a division of Cloudcast Media, and the Jackie Robinson Family YMCA. Please learn more about both of our sponsors by visiting:...
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    53 mins
  • Episode 19 | The Science Of Stem Cells | Dr. Shiri Gur-Cohen, Assistant Professor of Medicine, Division of Regenerative Medicine, UCSD

    Episode 19 | The Science Of Stem Cells | Dr. Shiri Gur-Cohen, Assistant Professor of Medicine, Division of Regenerative Medicine, UCSD
    Dec 12 2024
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich sit down to discuss THE SCIENCE OF STEM CELLS with Dr. Shiri Gur-Cohen, a stem cell biologist whose innovative work on lymphatic vascular niche for hair follicle stem cells opened the door to fundamental research areas to advance therapeutics for enhancing tissue regeneration. Dr. Gur-Cohen is currently an Assistant Professor of Medicine in the Division of Regenerative Medicine at the University of California San Diego. Dr. Gur-Cohen’s work with Dr. Elaine Fuchs at The Rockefeller University in New York helped unearth the lymphatic capillary network as a novel stem cell niche component, and her multidisciplinary strategy has advanced our knowledge of how stem cells synchronize and coordinate tissue regeneration. Dr. Gur-Cohen earned her Ph.D. in the Department of Immunology in Dr. Tsvees Lapidot’s lab at the Weizmann Institute of Science, Israel, and completed her B.A. in molecular biochemistry and M.Sc. in medical sciences at the Technion-Israel Institute of Technology. In this episode, you'll hear Dr. Gur-Cohen discuss her research on stem cells and their role in tissue regeneration. Dr. Gur-Cohen explains the difference between embryonic and adult stem cells, emphasizing the potential of adult stem cells to rejuvenate and regenerate tissues. She highlights the importance of understanding the balance between self-renewal and differentiation in stem cells. Dr. Gur-Cohen also addresses the ethical considerations and challenges in stem cell therapies, advocating for careful consultation with physicians. She envisions future advancements in cancer treatment and regenerative medicine, aiming to target cancer-initiating stem cells and rejuvenate old stem cells.Enjoy this episode and get your PODucation on!! EPISODE SUMMARY"Rapid Fire" Warm-Up Questions with Dr. Shiri Gur-CohenDr. Gur-Cohen shares her first science experiment involving collecting animals under rocks and observing their behavior in different light conditions.Dr. Gur-Cohen discusses her favorite musician, Taylor Swift, and her preference for dogs over cats, despite owning a cat due to lifestyle constraints in New York.Dr. Gur-Cohen expresses her desire to visit Antarctica for its extreme conditions and shares her favorite hiking experience in Patagonia.Dr. Gur-Cohen mentions her favorite place to eat in San Diego, highlighting the fresh seafood available in the area.Career Path and Passion for Stem Cell ResearchDr. Gur-Cohen recounts how her career in stem cell research was influenced by mentors who encouraged her to explore her true interests.Dr. Gur-Cohen explains her initial goal to cure cancer, which evolved into a fascination with stem cell biology during her PhD and postdoc years.Dr. Gur-Cohen discusses the importance of understanding how stem cells work in regenerating tissues and the impact of aging on this process.Dr. Gur-Cohen emphasizes the need to understand the balance between self-renewal and differentiation in stem cells to maintain tissue health.Types of Stem Cells and Their ApplicationsDr. Gur-Cohen explains the difference between embryonic and adult stem cells, noting that adult stem cells are already specialized and can only generate specific tissues.Dr. Gur-Cohen discusses her choice to study adult stem cells due to their visual and measurable properties, which are more applicable to human health.Dr. Gur-Cohen highlights the potential of adult stem cells to be taught to have a broader range of differentiation, similar to the regenerative abilities of amphibians like salamanders.Dr. Gur-Cohen elaborates on the importance of understanding the signals and cues that guide stem cells to change their fate during development.Challenges and Future of Stem Cell ResearchDr. Gur-Cohen discusses the challenges of stem cell transplantation, emphasizing the need to understand which stem cells are being used and their life cycle.Dr. Gur-Cohen advises caution when considering stem cell therapies, recommending consultation with physicians and thorough research on the safety and efficacy of treatments.Dr. Gur-Cohen shares her excitement about the potential of CRISPR technology to correct genetic diseases and the importance of understanding the signals that drive regeneration.Dr. Gur-Cohen expresses hope for the future of stem cell research, particularly in cancer treatment and regenerative medicine, and the potential to rejuvenate old stem cells.Audience Questions and Final ThoughtsDr. Gur-Cohen responds to an audience question about the challenges of running her own lab, mentioning funding and the importance of having a supportive environment.Dr. Gur-Cohen shares her experience of starting her lab with ...
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    42 mins
  • Episode 18 | The Science Of Cancer Genomics and Precision Medicine | Dr. Jason Sicklick, Co-Leader, UCSD Structural & Functional Genomics

    Episode 18 | The Science Of Cancer Genomics and Precision Medicine | Dr. Jason Sicklick, Co-Leader, UCSD Structural & Functional Genomics
    Nov 14 2024
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.

    In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich sit down to discuss THE SCIENCE OF STEM CELLS with Dr. Jason Sicklick, MD, an internationally recognized surgical oncologist who specializes in treating gastrointestinal stromal tumors (GIST), abdominal/retroperitoneal sarcomas, and liver tumors (primary and metastatic). He is co-leader of the UCSD Structural and Functional Genomics Program, co-leader of the Sarcoma Disease Team at UC San Diego Health and a member of the National Comprehensive Cancer Network Soft-Tissue Sarcoma Committee and GIST Subcommittee, which develops best practices for treating these rare and often challenging-to-treat cancers. A professor of surgery and pharmacology at UC San Diego School of Medicine, Dr. Sicklick conducts clinical research to improve our understanding of complex cancers, as well as enhance precision medicine approaches for treating metastatic cancers. His laboratory focuses on the molecular mechanisms of GIST development and drug resistance in advanced GIST. Dr. Sicklick, who joined UC San Diego Health in 2010, has co-authored over 130 peer-reviewed articles. His research findings have appeared in prestigious journals such as Nature Medicine, Nature, Gastroenterology, Oncogene, Clinical Cancer Research, Annals of Surgery, JAMA Surgery, and Annals of Surgical Oncology. He is on the editorial boards of Cancer and Journal of Gastrointestinal Surgery.Dr. Sicklick has received many awards and honors for his contributions to advancing GIST treatments. In 2021, he earned a Rare Impact Award from the National Organization for Rare Disorders (NORD). He is also a 2018 recipient of the RARE Champion of Hope in Medical Care and Treatment Award from the Global Genes Allies in Rare Disease, the largest global advocacy organization for those fighting rare, genetic diseases. In 2016, he was named the GIST Clinician of the Year by The Life Raft Group, the largest GIST patient advocacy group in the world. He is an elected member of the American Surgical Association, the nation's oldest and most prestigious honorary surgical society. Dr. Sicklick completed a surgical oncology fellowship at Memorial Sloan Kettering Cancer Center. He completed general surgery residency training at The Johns Hopkins Hospital and translational research training at Duke University Medical Center. He earned his medical degree from David Geffen School of Medicine at UCLA. He is board certified in general surgery and a fellow of the American College of Surgeons (FACS).

    Enjoy this episode and get your PODucation on!!

    TIME | DISCUSSION
    03:15 | About Dr. Sicklick
    07:03 | Rapid Fire Questions
    10:25 | The destiny of his career choice
    12:15 | Cancer genomics
    14:04 | Genomics and precision medicine
    15:13 | Genetic typos...can we hit backspace?
    20:12 | Genetic sequencing
    21:37 | Are we getting better at sharing data?
    24:20 | Creating more precise medicines
    30:00 | Audience questions
    39:29 | Advice to young science students

    Enjoy this excellent conversation, the "Rapid Fire" questions, and insights on a topic which is top of mind around the world.

    Be sure to subscribe to and share "The Science Of" with all of your friends. We appreciate your support.

    "The Science Of" podcast series is brought to you by the UCSD Moores Cancer Center, SchoolCAST, a division of Cloudcast Media, and the Jackie Robinson Family YMCA.

    Please learn more about both of our sponsors by visiting:
    www.moorescancercenter.ucsd.edu/
    www.cloudcastmedia.us
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    44 mins

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