Join Matt today as he explores the fascinating intersection of sleep, metabolism, and weight management, delving into the science of dual orexin receptor antagonists (DORAs). This episode dissects a groundbreaking study on suvorexant (Belsomra), an FDA-approved insomnia medication, and its potential to enhance fat burning during sleep. Matt unpacks the role of orexin, a neuropeptide crucial for wakefulness, and explains how DORAs work by targeting orexin receptors to promote natural sleep.

This preliminary research, conducted on healthy young men, reveals suvorexant's intriguing ability to not only improve sleep quality, but also increase fat oxidation while preserving muscle mass. While these initial findings are promising, Matt emphasizes the importance of cautious optimism and the need for further research in more diverse groups. He explores the implications for weight management and metabolic health, highlighting the potential of suvorexant as a novel approach to weight loss. However, Matt underscores that a holistic approach, including diet, exercise, and good sleep hygiene, remains essential for long-term success. Tune in today to gain valuable insights into the complex relationship between sleep and metabolism, and how scientific advancements may pave the way for innovative solutions in weight management.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Are sleep troubles keeping you up at night? Matt used to be a skeptic about meditation, but 7 years ago, he tried it using a fantastic meditation app called ‘Calm’, and it transformed his sleep! Now, he meditates for 10 minutes before bedtime every night! He’s also partnered with Calm who have been generous enough to offer his podcast listeners an exclusive 40% discount on their premium subscription! All you have to do is go to calm.com/mattwalker and take advantage of this incredible deal! Head on over now and improve your sleep today!

Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Escape the everyday and drift off to dreamland with Matt’s guided sleep story. Together, we'll journey through tranquil landscapes, from moonlit valleys to sun-dappled forests, letting the soothing sounds and imagery lull you into a peaceful slumber. This is a sleep story designed to ease your mind and gently guide you into a deep, restful sleep. If you find yourself struggling to unwind after a long day, allow this narrative to transport you to a place of tranquility and calm. Release your worries and embrace the stillness of the night as we embark on this relaxing journey together.

This episode is sponsored by BetterHelp. Just as we prioritize our physical well-being, nurturing our mental health is equally crucial. BetterHelp offers accessible online therapy, connecting you with licensed therapists from the comfort of your home. Visit betterhelp.com/MattWalker for 10% off your first month.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Matt dives deep into the science of memory with renowned neuroscientist Dr. Charan Ranganath, author of Why We Remember: Unlocking Memory's Power to Hold On to What Matters in today’s episode. Together, they explore the complex relationship between memory and the brain, touching on the roles of emotional significance, context, and even neuromodulators like dopamine in helping our brains decide which memories to retain and which to discard.

Dr. Ranganath shares his unique journey into memory research and insights from his pioneering work at the Dynamic Memory Lab at UC Davis, where his studies have reshaped our understanding of human memory. He also explains the diversity within memory types—such as episodic, semantic, and procedural memories—and why they’re all processed differently. Delving into extraordinary memory phenomena, he discusses hyperthymesia, false memories, and cases of severely deficient autobiographical memory, illustrating the varied ways people experience memory. This episode is a rich journey into the science and experience of memory, concluding with a refreshing reminder: sometimes, forgetting can be just as beneficial as remembering, offering us a balanced perspective on our memory's true role in daily life.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Long-time show sponsor LMNT is Matt Walker’s go-to for a sugar-free electrolyte mix. With the perfect electrolyte balance and science-backed formulation, LMNT is a product Matt trusts daily, adding it to his workouts and protein shakes. And now, for a seasonal twist, their Chocolate Medley range is back with flavors like Chocolate Mint and Matt’s favorite, Chocolate Raspberry. Get a free sample pack with any purchase at drinklmnt.com/mattwalker—just use his link to try it yourself!

Looking for comfort and style in your wardrobe? While fashion isn’t his expertise, Matt found the perfect fit with SKIMS—now a proud sponsor of the show - thanks to his better half’s recommendation. Known for their breathable, soft fabrics, SKIMS delivers the comfort Matt values most. Try SKIMS yourself and feel the difference! Visit skims.com, select “Podcast” at checkout, and choose "The Matt Walker Podcast" from the dropdown. Plus, explore their new holiday shop—just in time for the season!

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Dr. Charan Ranganath: https://charanranganath.com/