• Gabrielle Lyon’s protein recommendations, the problems with high-protein diets, and the major cost to her 1:1 protein-to-carb ratio suggestion
• Dr. Boz's take on the drivers of high fasting blood glucose on the carnivore diet
• Why Dr. Berg's view of serotonin as the "happy hormone" is unsubstantiated and our thoughts on his recommendations for raising serotonin
• How the Glucose Goddess's strategies for blood sugar regulation demonstrate a poor understanding of glucose and insulin
• Whether obesity is truly caused by genetics and if eating less and exercising more can influence obesity outcomes
• The benefits of sunlight and red-light exposure

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

1:46 – Gabrielle Lyon promotes bro science: 1 gram of protein per pound of bodyweight

7:15 – problems with high-protein diets – stress hormones, low testosterone, slowed metabolism, and gut toxins

15:21 – whether studies on Eskimo and Inuit populations support a high-protein diet

16:59 – the problems with Gabrielle Lyon’s recommendation of a 1:1 protein to carbohydrate ratio

23:48 – the minimum amount of carbs we need daily and the consequences of not getting enough

26:56 – Gabrielle Lyon is confused about fats

35:43 – types of fats commonly used in bodybuilding and whether they’re truly optimal

37:37 – Dr Boz’s recommendations for high blood sugar on carnivore and OMAD (one-meal-a-day)

45:59 – the drivers of high fasting blood glucose on low-carb diets

49:38 – whether overeating is really an issue on the carnivore diet and why increased appetite signals improved health

57:28 – whether Dr. Boz's recommendation to shift the eating window earlier has any validity

1:01:33 – Sean Baker’s shift away from the carnivore diet

1:03:31 –Dr Boz denies that the carnivore diet caused increased fasting blood sugar

1:11:16 – why Dr Berg is wrong – serotonin is not the “happy hormone”

1:20:40 – the idea that low serotonin causes depression and high serotonin reverses it is unsupported

1:23:05 – our thoughts on Dr. Berg's recommendations for raising serotonin: exercise, fasting, and tryptophan

1:28:46 – whether vitamin D increases serotonin

1:30:56 – the benefits of sunlight and red-light exposure

1:39:39 –the problems with Glucose Goddess’s strategies to prevent blood glucose spikes

1:49:22 – insulin and blood sugar spikes are misunderstood

1:54:46 – how an excessive focus on blood glucose and insulin misses the underlying issues

1:55:59 – is obesity primarily caused by genetics?

2:01:49 – whether diet and exercise impact obesity rates

2:09:26 – the vital importance of finding fulfillment in life, following our passions, and escaping the grind of the rat race

2:15:12 – what it really takes to be healthy and whether it's possible to improve your health without expensive interventions

• Why increasing lipolysis through low-carb diets, cold plunges, fasting, and excess exercise is not necessary for fat loss
• How less lipolysis can lead to more fat loss
• The role of fat release and free fatty acids in diabetes, fatty liver disease, and obesity
• What to focus on instead of lipolysis to support healthy fat loss

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-127-lipolysis-and-fat-loss-lose-body-fat-without-increasing-fat-burning/

Timestamps:

0:00 – intro

1:08 – the fat loss narrative: release more fat from your fat stores through intense exercise, fasting, cold plunges, and low-carb diets

4:08 – how fat gets released from our fat stores

8:40 – the baseline rate of fat release from our fat stores and the impact of degenerative states like cancer on lipolysis

12:09 – how fat is released from our fat stores in response to stressors like exercise

15:34 – the connection between lipolysis, metabolic syndrome, and fatty liver disease

23:29 – the research showing that decreasing lipolysis leads to less body fat (not more)

33:47 – whether we want to block hormone-sensitive lipase (HSL) activity

37:47 – the research showing that increasing fat burning and lipolysis does not increase fat loss

44:25 – how to lose body fat without relying on stress-driven fat oxidation

49:56 – strategies for fat loss without increased lipolysis: are exercise, fasting, and cold plunges the solution?

• How Jack & Dalton from Analyze & Optimize were introduced to the work of RayPeat
• Robert Lustig's claims that fructose is as harmful to the liver as alcohol
• Whether Jordan Peterson’s Serotonin Hierarchy has any merit
• The negative effects of the carnivore diet, especially on gut health
• The link between birth control and cancer and the protective effects of progesterone
• What we think of Dave Asprey’s thoughts on the “Ray Peat diet”

Analyze & Optimize's Website: https://www.analyzeandoptimize.io/

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

0:38 – how Analyze & Optimize (Jack & Dalton) got introduced to work of Ray Peat

6:32 – how Analyze & Optimize create their videos

10:40 – refuting Robert Lustig's claims – is fructose as harmful to the liver as alcohol?

17:40 – whether Analyze & Optimize are paid by “big sugar”

20:30 – Robert Lustig’s fructose claims are unsupported

28:06 – is white sugar safe to consume?

33:04 – Serotonin & Hierarchy by Jordan Peterson

34:33 – SSRI use and serotonin’s role in promoting learned helplessness and anhedonia

40:46 – how the perceived benefits of serotonin could be attributed to other factors

45:45 – whether serotonin is the “dominance” hormone

47:17 – Analyze & Optimize respond to Shawn Baker on sugar cravings being a sign of health and youth

51:04 – declining health on the carnivore diet, whether it’s sustainable, and why your immune system needs carbohydrates

54:04 – carnivore diet effects on gut health – quorum sensing, biofilms, high stress hormones, and damage to thyroid health

1:01:30 – why chronic low-calorie intake turns down metabolic function and leads to obesity

1:07:00 – the harm caused by conflating progesterone and synthetic progestins

1:14:57 – the link between birth control and cancer and the protective effects of progesterone

1:18:20 – the negative effects of synthetic progestins and estrogen, especially unchecked by natural progesterone

1:24:45 – Why Is the Right So Obsessed with Seed Oils? by Ej Dickson

1:31:15 – Dave Asprey argues with Paul Saladino on supplements vs orange juice

1:39:10 – whether Ray Peat’s ideas and principles promote orthorexia

1:44:22 – using precision medicine vs. listening to your body

1:51:09 – where to find more of Jack & Dalton’s work

• What causes increased triglycerides on a high-carb diet
• Whether the small, dense LDL particles are really the culprits behind cardiovascular disease
• How lipid values on a high-carb diet compared to a low-carb diet, including lean mass hyper responders
• Whether low HDL levels will increase your risk of heart disease
• Whether high triglyceride levels cause heart disease

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-126-high-triglycerides-on-a-high-carb-diet-should-you-be-worried/

Timestamps:

0:00 – intro

1:10 – whether elevated triglycerides on a high-carbohydrate diet warrant concern

3:21 – the association between LDL, cardiovascular disease, and metabolic syndrome

5:52 – the lipid energy model and what accounts for the lipid values seen in Lean Mass Hyper-Responders (LMHR)

9:26 – what causes higher triglycerides seen on higher-carb, lower-fat diets in someone who is insulin sensitive

11:39 - what causes high triglycerides in insulin resistance

18:08 – are elevated triglyceride levels on a high-carb diet concerning, and do they drive cardiovascular disease?

24:08 – whether small, dense LDL and low HDL levels drive heart disease

28:25 – native cultures showing high triglycerides on a high-carb diet with no signs of cardiovascular disease:Tarahumaras, Tukisenta, and the Kitavans

34:10 – high-carb diets support insulin sensitivity and don’t increase uric acid levels in the Tukisenta

37:23 –high-carb diets support insulin sensitivity without increased activity levels in the Kitavans

43:43 – when elevated triglycerides might become a concern after increasing carbohydrate intake

• What Layne Norton is missing regarding seed oils
• What we think of Liver King’s steroid use and how this relates to fitness culture and unhealthy body image
• Ben Bikman’s complete misapplication of a study regarding blood sugar and insulin resistance
• Jay’s response to Thomas DeLauer regarding omega-3s and cod liver oil

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

0:28 – Andrew Huberman and Layne Norton on whether seed oils are inherently harmful

4:18 – why Layne Norton's "calories-only" view is flawed, as it ignores how the type of food actually affects our bodies

9:58 – whether animal studies are useful in nutritional research, or if only human randomized control trials (RTC) should be considered

15:57 – problematic assumptions and biases in nutritional research and how they can shape research outcomes

20:59 – why the reported health benefits of polyunsaturated fats in research are misleading and harmful

26:54 – the connection between chronic disease and polyunsaturated fats, and how focusing solely on calories relieves the food industry of responsibility for health outcomes

31:43 – Liver King's self-esteem, body image struggles, steroid use, health risks, and why his apology was commendable

41:36 – why cultural standards for physical appearances are unrealistic, unhealthy, and can lead to conflating steroid-enhanced bodies for genuine health

51:12 – health risks associated with steroid-use and having too much muscle mass

1:00:34 – Thomas Delauer and Derek from moreplatesmoredates discuss omega-3s

1:06:21 – whether the antioxidants in fish oil are worth the damage caused by lipid peroxidation

1:10:54 – whether cod liver oil is any better than fish oil

1:17:11 – how to effectively hydrate your cells and the importance of getting enough salt

1:24:44 – why consuming a lot of plain water without electrolytes actually impairs hydration, contributing to increased swelling, increased stress, and impaired energy production

1:32:38 – the importance of getting adequate potassium in addition to salt intake

1:38:03 – factors that may increase your need for water

1:40:02 – what Ben Bikman misses when it comes to blood glucose and insulin resistance

1:48:15 – the true relationship between insulin and blood sugar regulation

1:54:30 – Ben Bikman misapplies this study: it does not support that carbohydrates cause insulin resistance

2:00:38 – creating content in the health sphere, choosing high quality foods, and the benefits of tracking food (using Cronometer or another similar app)

In this episode we discuss:

• Whether estrogen is just a reproductive hormone
• Whether you need to be concerned about testosterone converting to estrogen
• How you can have excess estrogen production even after menopause
• The best way to use progesteron
• Whether Calcium D-glucarate is effective for lowering estrogen

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-124-forget-about-cico-a-smarter-approach-to-fat-loss/

Timestamps:

0:00 – intro

1:07 – our thoughts on Wendy Sellens’ recent interviews with the Strong Sistas (Ashley and Sarah Armstrong)

6:30 – the importance of reviewing research with an open mind, avoiding any rigid or authoritative stance

9:38 – whether all research should be rejected due to Rockefeller funding and whether Dr Ray Peat was “Rockefeller trained”

15:47 – whether reproductive hormones affect only reproductive organs

20:35 – how hormonal imbalances affect all areas of health—reproduction, digestion, edema, bloating, cancer risk, weight gain, brain health, bone health, and muscle growth

23:38 – whether Dr Hobbins’ experiments proved that there are no receptors for reproductive hormones in non-reproductive organs

26:51 – why Wendy’s claim—that the rise in estrogen during pregnancy is caused by exogenous compounds (phytoestrogens and xenoestrogens)—is incorrect

29:29 – estrogen’s role as a growth-promoting hormone and how progesterone counterbalances it by promoting cellular differentiation

35:47 – whether testosterone can be converted into estrogen

36:52 – how you can have excess estrogen production even after menopause and problems with estrogen testing

40:19 – body fat as a major source of estrogen

44:33 – why Wendy’s claim that calcium D-glucarate increases estrogen is incorrect

46:56 – the mechanism through which calcium D-glucarate effectively lowers estrogen levels

50:28 – confounding variables that make it difficult to accurately interpret the results of breast thermography scans

In this episode we discuss:

• The criticism of Georgi regarding estrogen and cancer
• The major point that Siim Land is missing when it comes to increasing NAD+
• Why we think Dr. Berg is completely wrong on serotonin
• Nutrition With Judy’s suggestion that thyroid issues on a carnivore diet are not caused by the lack of carbohydrates, and why we think this isn’t the case
• Dave Asprey’s recommendation to drink orange juice and whether it’s for the right reasons

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

1:10 – whether estrogen is a carcinogen

6:13 – estrogen’s role in driving weight gain and chronic diseases such as cancer, Alzheimer’s disease, and Type 2 Diabetes

8:03 – the dangers of synthetic progesterone (progestin) use

10:14 – the difference between estrone and estradiol and the problems with estrogen testing

16:14 – whether estrogen therapy should be used in post-menopausal women

17:17 – the difference between oral and transdermal estrogen use

24:44 – the connection between inflammation and estrogen production

27:57 – why estrogen levels are not actually low in post-menopausal women

37:59 – our take on Siim Land's post on NAD+ and mitochondrial uncoupling

48:25 – why intentionally seeking hormetic responses, like the activation of heat-shock proteins, should be avoided

50:37 – which form of CoQ10 is better: ubiquinone or ubiquinol

53:34 – what Siim Land and many others get wrong when it comes to raising NAD+

55:44 – does fasting and AMPK upregulation cause cancer?

1:00:29 – fat fuels cancer and why not to restrict sugar for cancer

1:09:56 – Dr Berg’s take that serotonin is the “happy hormone” – why we disagree

1:19:06 – serotonin’s role in driving chronic diseases and conditions including depression, anxiety, IBS, and cancer

1:27:24 – Nutrition with Judy claims that the low thyroid levels generally seen on the carnivore diet have nothing to do with a lack of carbohydrates

1:39:01 – how the rate of living theory changed mainstream medicine’s view that thyroid health is important

1:45:37 – how excessive exercise raises stress hormones, setting you up for weight regain

1:51:30 – why the combination of fasting and exercise is detrimental to our health

1:53:44 – how estrogen is used to fatten animals

2:02:42 – why Dave Asprey is talking about endotoxin and orange juice

2:07:00 – whether the sugar in orange juice feeds bacteria and increases endotoxin

2:09:40 – why the low-carb trend keeps resurfacing, despite the growing evidence against it

2:14:41 – where to find Georgi and IdeaLabs

In this episode we discuss:

• An alternative framework to CICO for conceptualizing fat loss
• Why eating less and exercising more is not the best solution for fat loss
• Why excess energy does not cause fat gain and instead leads to fat loss
• How you can get stuck in a cycle of weight gain, undereating, and constant hunger, and how to get out of that cycle

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-124-forget-about-cico-a-smarter-approach-to-fat-loss/

Timestamps:

0:00 – intro

1:06 – recapping the problems with CICO

5:02 – the Energy Balance approach as an alternative to CICO for fat loss

12:12 – why calories do not equal energy and considering the possible fates of the food we consume

17:39 – efficient mitochondrial function as a central piece that determines whether substrate will be stored as body fat

19:39 – the amount of food you eat does matter

21:46 – conceptualizing Energy Balance with numerical units

24:00 – fat gain as a consequence of impaired mitochondrial function

29:01 – how you can lose fat while eating more

33:12 – the effects of energy availability on hunger and stress hormones

36:41 – how stress hormones, along with energy deficits, cause the body to break down muscle, bone, and skin for energy

43:16 – the benefits of having an energy surplus: improved sleep, immune function, digestion, cognitive function, and more

46:20 – comparing the Energy Balance approach with CICO and the major cost of the advice to “eat less and exercise more