Associate Professor Yen Ying Lim is a clinical psychologist and researcher. Her primary research interests are in integrating and translating the effects of genetic, biological, and lifestyle factors on cognitive decline and clinical disease progression in Alzheimer’s disease. She is also interested in the development and validation of web-based cognitive tests for the early detection of cognitive dysfunction in preclinical Alzheimer’s disease.

Yen dedicates her dementia research work to people in their midlife (ages 40-70) who have a family history of dementia. She focuses on detecting early signs of Alzheimer's Disease, even in individuals who currently show no symptoms of dementia. This early detection presents a fascinating dilemma. While these individuals can't be officially classified as having early-onset Alzheimer's, they are intriguing cases to study. They might face a heightened risk of developing dementia in the future, though there's also a possibility they may never experience it. Tracking their progress could provide invaluable insights into the onset and progression of dementia.

Yen explains the world of cognitive assessments and how the tests evaluate memory, executive function, attention, language, and processing speed. These assessments offer a window into the brain's intricate workings, capturing a spectrum of cognitive domains to better understand cognitive health.

With the onset of COVID-19, Yen is at the forefront of pioneering online cognitive assessments, responding to the need for flexible, accessible testing. The traditional face-to-face evaluations often require travel, which can be a significant barrier for many. Yen weighs the advantages and limitations of both online and in-person assessments, highlighting how online options can reduce logistical hurdles but may lack the controlled environment of in-person testing.

Yen explains the comprehensive nature of neuropsychological tests and the reasons behind their sometimes unconventional design. However, many existing tests were created for highly educated, Western populations, leading to potential disadvantage among diverse groups. Hence people may score worse on a test, not because of cognition, but because a word in the test is unfamiliar. Yen is deeply committed to dementia research across culturally and linguistically diverse populations. She strives to ensure that cognitive assessments and related advice are both culturally appropriate and sensitive, enhancing their relevance and effectiveness.

"The most important modifiable dementia risk factor is the one that you are willing to address”

Hosted by Darshini Ayton and Sarah Carmody

Produced by Darshini Ayton

Music by Luke Champion

An initiative of the Centre of Research Excellence in Enhanced Dementia Diagnosis which is funded by the Australian National Health and Medical Research Council.

This podcast was recorded on Wurundjeri Country. We acknowledge the Traditional owners and custodians of the Wurundjeri Land, the Boonwurrung and the Woiwurrung peoples of the Kulin Nation. We pay our respect to their Elders past and present. Lands which Sovereignty was never ceded. Always was, always will be Aboriginal Lands.