After a major surgery on her leg, Cheryl is feeling fine, but pup Sami tells her mommy that she needs to get back to the hospital STAT.

When Julie's pup Marley starts acting strange, refusing to leave her side, she takes him to the veterinarian - and Marley gets a clean bill of health. So she goes to the doctor to get some blood work done on herself. And that trip to the doctor saves her life.

When a series of tragedies leaves Jonathan homeless, he and his beloved pup Evelyn spend three winter months sleeping in his tiny car, using the engine to keep themselves warm. One particularly cold night, the engine breaks down, leaving them without heat, and Jonathan decides his life is over and passes out from the cold. But Evelyn refuses to let Jonathan go.

When Ashley finds herself stuck in an abusive relationship, only the intervention of her pup Zeda could make her walk away.

Danelle, a professional endurance athlete, was out for a run when she fell off a cliff, plummeting 60 feet to the ground and shattering her pelvis. Unable to drag herself out of the canyon, her pup Taz refused to leave her side. Until she told him to.

When Janet's house goes up in flames, the babysitter gets one child to safety, while the family's pitbull Blue stays behind in the collapsing, smoke-filled house with the youngest daughter. Can Blue save the child's life?

When Michael's car crashes 50 feet into a ravine, his legs are pinned and he can't move. The only has for survival is his six-month-old puppy Honey.