• Episode 203: Acetaminophen Toxicity

  • Dec 2 2024
  • Length: Less than 1 minute
  • Podcast

Episode 203: Acetaminophen Toxicity

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  • Summary

  • We sit down with one of our toxicologists to discuss acetaminophen toxicity.

    Hosts:
    Marlis Gnirke, MD
    Brian Gilberti, MD

    https://media.blubrry.com/coreem/content.blubrry.com/coreem/Acetaminophen_Toxicity.mp3 Download One Comment Tags: Toxicology Show Notes Table of Contents

    0:35 – Hidden acetaminophen toxicity in OTC products

    3:24 – Pharmacokinetics and toxicokinetics

    6:06 – Clinical Course

    9:22 – The antidote – NAC

    11:02 – The Rumack-Matthew Nomogram

    17:36 – Treatment protocols

    22:34 – Monitoring and Lab Work

    23:23 – Considerations when treating pediatric patients

    23:57 – IV APAP overdose, fomepizole

    25:42 – Take Home Points

    Acetaminophen vs. Tylenol:

    • The importance of recognizing that acetaminophen is found in many products beyond Tylenol.
    • Common medications containing acetaminophen, such as Excedrin, Fioricet, Percocet, Dayquil/Nyquil, and others.
    • The risk of unintentional overdose due to combination products.

    Prevalence of Acetaminophen Toxicity:
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