In this episode of Daily Value, we look at newer research on melatonin that challenges conventional wisdom. A recent meta‐analysis questions current clinical guidelines on melatonin use for sleep, suggesting there may be a dual (Dose X Time effect) secret to optimizing its effects. We’ll break down the scientific clues behind optimal dosing, timing, and formulation, leaving you to wonder if you've been taking melatonin all wrong.

Discussion Points:

• The clinical recommendations for melatonin may be “off”.
• What a recent meta-analysis (PMID: 38888087) suggests as better dosing and timing of melatonin.
• Formulation differences between fast-acting and extended-release melatonin.
• Practical tips for tailoring melatonin to boost your sleep quality.

https://pubmed.ncbi.nlm.nih.gov/38888087/

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In this episode of Daily Value, we look at the latest research on B vitamins and their in neuropsychiatric disorders. A newly published meta-analysis suggests a causal relationship between B vitamin deficiencies and neuropsychiatric disorders. We will break down the scientific findings on B6, B12, and folate, shedding light on their roles in conditions like Parkinson’s disease.

Discussion Points:

• How recent genetic studies support a causal link between B vitamin deficiencies and mental health conditions.
• The role of B vitamins in reducing neurotoxicity and slowing brain atrophy.
• How vitamin B12 may protect against dopamine neuron loss and disease progression.
• Evidence linking low B6 levels to neurotransmitter imbalances and schizophrenia risk.
• The impact of folate on one-carbon metabolism and its protective role in neurodegeneration.

https://www.sciencedirect.com/science/article/abs/pii/S0149763425000685#:~:text=In a meta-analysis of,beneficial for certain specific diseases.

https://pubmed.ncbi.nlm.nih.gov/26757190/

https://pubmed.ncbi.nlm.nih.gov/32257364/

https://pubmed.ncbi.nlm.nih.gov/30858560/

https://pubmed.ncbi.nlm.nih.gov/32424116/

https://pubmed.ncbi.nlm.nih.gov/33941768/

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In today’s episode of Daily Value, we explore the possibly underappreciated role of vitamin K in brain health and neuroprotection. Recent research (doi: 10.3389/fnut.2024.1396707) reveals a connection between dietary vitamin K intake and reduced levels of neurofilament light chain, a potential biomarker for neurodegeneration, particularly in middle-aged and older adults. We’ll discuss how vitamin K supports neuronal function, what specific forms of vitamin K are most important, and how this nutrient might help slow cognitive decline as we age.

Episode Talking Points:

*The role of neurofilament light chain as a biomarker for brain health and its association with neurodegeneration.
*Findings from a recent study (doi: 10.3389/fnut.2024.1396707) showing how higher vitamin K intake (and a specific amount) is linked to lower neurofilament light chain levels.
*The potential of vitamin K, and possibly MK-4, to protect neurons through mechanisms like sphingolipid metabolism and anti-inflammatory effects.

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1396707/full

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