On today's podcast:
1) Israel attacks Iran's nuclear and ballistic missile programs in a major escalation of hostilities and oil prices surged on fears of a wider war. Iran has vowed reprisals and sent drones toward Israel. The UN atomic watchdog says there are no signs of increased radiation at Iran’s main enrichment site. The airstrikes did kill the commander of Iran’s Revolutionary Guard. The US says it knew of the Israeli attack beforehand but was not involved. It warned Iran against targeting US assets.

2) An appeals court lets President Trump keep using the National Guard in Los Angeles for now. A 3-judge panel of the 9th US Circuit Court of Appeals put on hold a judge's order to pull back on the Trump administration's use of military troops in Los Angeles to deal with protests over immigration raids. The appeals court scheduled a hearing for Tuesday to discuss further action in the case, with written arguments from the administration and California due before then.

3) Frontrunners take aim at each other in the final New York City mayor's debate. democratic candidates held their second debate ahead of this month's primary election. The 33 year old socialist state Assemblyman Zohran Mamdani, who has become one of top contenders in the race, found himself the target of jabs from former Governor Andrew Cuomo. Cuomo, who is in the midst of a political comeback after resigning as governor over a sexual harassment scandal, has long been the favorite.

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A Boeing Co. 787 Dreamliner aircraft operated by Air India that was bound for London crashed shortly after taking off in Ahmedabad, in what stands to be the worst accident involving the US planemaker’s most advanced widebody airliner.
Flight AI171 was carrying 242 passengers and crew. Video footage shared on social media showed a giant plume of smoke engulfing the crash site, with no reports of survivors.
The aircraft entered a slow descent shortly after taking off, with its landing gear still extended before exploding into a huge fireball upon impact. The crash took place in a residential area, which could mean a higher death toll. The twin-engine plane had reached an altitude of 625 feet (190.5 meters) at a speed of 174 knots, according to data from Flightradar24.
The accident extends a series of serious and fatal incidents in the civil aviation industry this year, including a mid-air collision in Washington early in 2025 between a military helicopter and an aircraft. Air India is in the middle of a strategic turnaround that includes a huge aircraft order as it seeks to tap growing demand from a rising Indian middle class.
Indian Prime Minister Narendra Modi said the accident is “heartbreaking beyond words,” according to a statement, adding that he’s been in touch with ministers and authorities assisting the salvage operation.
Boeing shares fell 7% in premarket US trading. The 787 is the company’s most advanced in-service aircraft and is popular with airlines because it is more fuel efficient thanks to its use of lightweight composite materials. Boeing said it’s “aware of initial reports and are working to gather more information.”

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On today's podcast:

1) An Air India Ltd. Boeing Co. 787 aircraft traveling from Ahmedabad in India to London’s Gatwick airport crashed shortly after taking off, in what stands to be the most serious accident involving the US planemaker’s most advanced widebody airliner. The airline said that Flight AI171 was “involved in an incident” and that Air India is “ascertaining the details.” Footage shared on social media showed a giant plume of smoke engulfing the crash site, with no reports of fatalities or survivors. The flight was carrying 242 passengers and crew, according to news agency ANI.

2) Los Angeles spends another night under curfew as protests spread to more cities. Protests over immigration raids in Los Angeles have spread to other US cities, including New York, Chicago, and Milwaukee, with clashes between protesters and law enforcement. The federal government has expanded its show of force, deploying National Guard troops and authorizing the use of the Hobbs Act to take over criminal cases, which California officials have criticized as "unlawful, unconstitutional and undemocratic".

3) President Trump says he will set unilateral tariffs on countries in 2 weeks. The president plans to send letters to trading partners in the next one to two weeks setting unilateral tariff rates ahead of a July 9 deadline. President Trump has threatened to impose higher duties on dozens of economies, but has only reached a trade framework with the UK and a tariff truce with China, which was recently threatened.

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On today's podcast:
1) The US and China capped two days of high-stakes trade talks with a plan to revive the flow of sensitive goods — a framework now awaiting the blessing of Donald Trump and Xi Jinping.
2) Elon Musk, who served as a close adviser and confidante to President Donald Trump until a bitter public falling out last week in a series of social-media posts, issued his strongest sign of contrition yet over how he handled the rupture.
3) California Governor Gavin Newsom accused President Donald Trump of misusing his power by mobilizing troops in Los Angeles and warned other states to prepare for similar unrest, as protests over immigration raids stretched into a fifth night and led to a curfew in parts of the city’s downtown.

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On today's podcast:
1) The Trump administration escalated its response to anti-deportation protests in Los Angeles with the mobilization of 700 Marines, deploying active-duty military on the ground and increasing tensions with California officials.
2) Trade talks between the US and China will continue into a second day, according to a US official, as the two sides look to ease tensions over shipments of technology and rare earth elements.
3) Mark Zuckerberg, frustrated with Meta Platforms Inc.’s shortfalls in AI, is assembling a team of experts to achieve artificial general intelligence, recruiting from a brain trust of AI researchers and engineers who’ve met with him in recent weeks at his homes in Lake Tahoe and Palo Alto.

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On today's podcast:

1) Tensions flared in Los Angeles on the third day of anti-deportation protests, as demonstrators clashed with law enforcement while President Donald Trump and California Governor Gavin Newsom exchanged blame over the unrest and responsibility for restoring order.

2) The US and China are set to resume trade negotiations in London on Monday in a bid to further defuse tensions over rare-earth minerals and advanced technology following a phone call between leaders Donald Trump and Xi Jinping last week.

3) Apple Inc. shares have been heavily tethered to US trade policies this year, but its annual developer’s conference could refocus Wall Street’s attention on a potentially bigger problem: its struggles with artificial intelligence.

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Damian Sanchez, (Damian J to music fans) is a Miami-based jazz musician. A car accident landed him in the hospital with multiple fractures to his leg. Once there, he faced the difficult decision of whether or not to take the pain medication that was offered to him. With patients like Damian in mind, Dr. Paul Negulescu and the research team at Vertex are thinking differently about pain – they’re investigating potential non-opioid based treatment options that aim to target pain differently.

This episode of Targeting the Toughest Diseases is sponsored by Vertex Pharmaceuticals.

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Bloomberg Daybreak Weekend with Tom Busby takes a look at some of the stories we'll be tracking in the coming week.

• In the US – a look ahead to U.S CPI and PPI data and Tesla’s Robotaxi launch.
• In the UK – a look ahead to London’s Tech Summit.
• In Asia – a look ahead to readings on Chinese exports, as well industrial production and retail sales.

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