Is it possible for artificial intelligence to not only understand but also rewrite the very code of life?

In this episode, we delve into the groundbreaking capabilities of a new AI model called Evo2. Imagine a system that reads the genetic code of millions of organisms and understands it well enough to predict the impact of genetic changes. This is where Evo2 shines, functioning almost like a virtual geneticist. Trained on trillions of DNA and RNA base pairs, Evo2 doesn't just memorize sequences; it learns the underlying rules, allowing it to predict gene functions and the effects of mutations. This ability to predict "fitness" of sequences could revolutionize personalized medicine by anticipating how genetic mutations might influence disease risk or drug responses.

Meet Evo2: The AI Model Redefining Genetic Insights

Evo2's capabilities extend far beyond mere analysis. By leveraging vast datasets, it can predict the stability of messenger RNA, a key factor in gene expression, and even tackle complex human clinical datasets like ClinVar and BRCA1. This AI model is breaking new ground by analyzing non-coding DNA regions, which are crucial for gene regulation and disease predisposition. Evo2's understanding is so profound that it can also generate new DNA sequences, a feat tested on the genomes of extinct species like the woolly mammoth and even entire bacterial genomes. This highlights Evo2's potential to not only read but also write genetic code, raising intriguing questions about the implications of such capabilities.

Exploring the Frontiers and Ethical Implications of AI in Genetics

The episode explores Evo2's potential to design genomes with specific epigenetic patterns, thanks to its integration with other AI models that predict chromatin accessibility. This level of control over gene expression opens doors to designing cells with tailor-made properties, which could revolutionize fields like biotechnology and medicine. However, with great power comes great responsibility. The hosts discuss the ethical concerns and potential risks, such as unintended ecological impacts or misuse of the technology. The researchers behind Evo2 are committed to transparency and collaboration, making their work open source and engaging with bioethicists and policymakers to ensure responsible innovation. As we stand on the brink of a new era in biology, the episode leaves us pondering the profound question of what it means to be human in a world where AI can manipulate the very building blocks of life.

00:00:00 - Introduction to Evo2

00:00:13 - Reading and understanding the genetic code

00:00:54 - Learning the underlying rules of the genome

00:01:54 - Prediction of mutations and applications

00:02:40 - Evo2's predictive capability successfully tested

00:03:22 - Analysis of mRNA sequences by Evo2

00:04:28 - Analysis of human clinical data

00:05:20 - Techniques for examining Evo2

00:06:20 - Analysis of the woolly mammoth genome

00:06:53 - Generation of new DNA sequences

00:07:47 - Testing genomes generated by Evo2

00:11:23 - Epigenetic control and implications of Evo2

00:14:00 - Responsibility and ethical implications

This episode is brought to you by Patrick DE CARVALHO and the production studio "Je ne perds jamais." Let's speak AI and explore the future together.
https://www.linkedin.com/in/patrickdecarvalho/

What are the potential risks and opportunities of advanced AI?

Welcome to this deep dive into the rapidly evolving world of artificial intelligence. Have you ever wondered about the capabilities and potential risks of advanced AI systems? In this episode, we explore the 2025 AI Security Report, which provides a comprehensive, neutral overview of the latest research from experts worldwide. From manipulation and misinformation to labor market disruptions and environmental impacts, the report offers a balanced perspective on the challenges and opportunities presented by AI. As AI continues to evolve at a breathtaking pace, what does this mean for the future of our society?

Meet the experts behind the insights.

The episode features insights from a diverse group of experts who contributed to the AI Security Report. These specialists hail from countries like Canada, Chile, China, the EU, France, Germany, India, and Indonesia, among others. Their collective expertise provides a global perspective on AI's rapid advancements and the accompanying risks. By gathering these voices, the report aims to offer a balanced and comprehensive understanding of AI's current state and future trajectory.

Navigating the future of AI: Risks, governance, and ethical considerations.

This episode delves into the complex landscape of AI development, highlighting both the technological advancements and the potential risks associated with AI systems. Key topics include the rapid scaling of computational resources, the emergence of unforeseen AI capabilities, and the challenges of ensuring AI safety and accountability. The discussion also covers the potential for AI misuse in generating fake content, conducting cyber attacks, and even enhancing bioweapons. As we navigate these challenges, the report emphasizes the importance of risk management, ethical guidelines, and transparent governance to harness AI's potential while mitigating its risks. The episode concludes by encouraging listeners to stay informed, engage in conversations about AI, and advocate for responsible AI development.

00:00:00 - Introduction and Episode Objective

00:00:24 - Rapid Evolution of AI

00:00:56 - Key Risks and the Concept of Scaling

00:02:14 - Emergent Capabilities and Surprises of AI

00:03:29 - Threat of Misinformation and Manipulation

00:04:57 - Systemic Risks and the Job Market

00:05:59 - Environmental Impact of AI

00:07:44 - Risk Management and Governance

00:08:51 - Proactive Approach and Red Team Formation

00:10:26 - Gap in Legal Framework and Regulation

00:12:44 - Importance of Transparency

00:15:00 - Collaboration and the Role of Society

This episode is brought to you by Patrick DE CARVALHO and the production studio "Je ne perds jamais." Let's speak AI and explore the future together.
https://www.linkedin.com/in/patrickdecarvalho/

How would you feel about humanoid robots seamlessly integrating into our daily lives?

In this episode, we explore the rapidly advancing world of humanoid robots, focusing on Figure AI, a company turning science fiction into reality. Figure AI's ambition is not just about creating robots for specific tasks but designing general-purpose robots capable of functioning in various environments, from factories and homes to space missions. With their valuation soaring to nearly $40 billion and robots already being delivered to customers, Figure AI is making significant strides in the robotics industry. Join us as we delve into this fascinating journey and unpack the technological and economic implications of these advancements.

Figure AI is at the forefront of the robotics revolution, and their flagship model, Figure 2, showcases their innovative approach. With partnerships with major players like OpenAI, Figure AI is equipping their robots with advanced AI capabilities, allowing them to learn, adapt, and even reason like humans. This episode features insights into the practical applications of these robots, from manufacturing and logistics to healthcare and even space exploration. The company's collaboration with BMW exemplifies how humanoid robots are already being integrated into industries, performing tasks that are repetitive or hazardous for human workers.

Throughout the episode, we discuss the broader implications of humanoid robots on the workforce and the economy. While there are concerns about job displacement, the conversation also highlights the potential for robots to augment human capabilities, leading to more efficient and productive work environments. The discussion extends to the ethical considerations surrounding data privacy, algorithmic bias, and the need for transparency and accountability in AI systems. As we navigate this technological revolution, the episode encourages listeners to engage in thoughtful dialogue and consider how we can shape a future where humans and robots collaborate for a more equitable and prosperous world.

- 00:00:00 - Start and Introduction

- 00:00:13 - Vision of Figure AI

- 00:00:50 - Funding and Flagship Model

- 00:02:00 - Robots with Advanced AI

- 00:03:00 - Strategic Partnership with BMW

- 00:04:30 - Applications in Logistics and Healthcare

- 00:06:59 - Robots in Space Exploration

- 00:07:40 - Future of Work and Human-Robot Collaboration

- 00:11:33 - Economic Impacts and Adaptation

- 00:14:50 - Economic Risks and Benefits

- 00:17:20 - Ethical Considerations and Challenges

- 00:20:07 - Conclusion and Call to Action

This episode is brought to you by Patrick DE CARVALHO and the production studio "Je ne perds jamais." Let's speak AI and explore the future together.
https://www.linkedin.com/in/patrickdecarvalho/