The year is 1087, and a pox is sweeping through the Italian city of Bari. When a lowly monk is visited by Saint Nicholas in his dreams, he interprets the vision as a call to serve the sick. But his superiors, and the power brokers they serve, have different plans for the tender-hearted Brother Nicephorus. Enter Tyun, a charismatic treasure hunter renowned for “liberating” holy relics from their tombs. The seven-hundred-year-old bones of Saint Nicholas are rumored to weep a mysterious liquid that can heal the sick, Tyun says.

When the immortal goddess Hera and her brother Zeus overthrow their tyrannical father, she dreams of ruling at his side. But as they establish their reign on Mount Olympus, Hera begins to see that Zeus is just as ruthless and cruel as the father they betrayed. While Zeus ascends, Hera is relegated to the role of wife and mother, a role she never wanted. She was always born to rule, but must she lose herself in perpetuating this cycle of violence and cruelty? Or can she find a way to forge a better world?

Provence, 1347. Eleanore (Elea) Blanchet is a young midwife and herbalist with remarkable skills. But as she learned the day her mother died, the most dangerous thing a woman can do is draw attention to herself. She attends patients in her home city of Avignon, spends time with her father and twin sister, gathers herbs in the surrounding woods, and dreams of the freedom to pursue her calling without fear.

High school senior Andrew Perrault finds refuge in the twisted fairy tales that he writes for the only person who can ground him to reality—Thomas Rye, the boy with perpetually ink-stained hands and hair like autumn leaves. And with his twin sister, Dove, inexplicably keeping him at a cold distance upon their return to Wickwood Academy, Andrew finds himself leaning on his friend even more. But something strange is going on with Thomas. His abusive parents have mysteriously vanished, and he arrives at school with blood on his sleeve.

In 1938, a dead whale washes up on the shores of remote Welsh island. For Manod, who has spent her whole life on the island, it feels like both a portent of doom and a symbol of what may lie beyond the island's shores. A young woman living with her father and her sister (to whom she has reluctantly but devotedly become a mother following the death of their own mother years prior), Manod can't shake her welling desire to explore life beyond the beautiful yet blisteringly harsh islands that her hardscrabble family has called home for generations.

Virginia, 1864—Libby Steadman’s husband has been away for so long that she can barely conjure his voice in her dreams. While she longs for him in the night, fearing him dead in a Union prison camp, her days are spent running a gristmill with her teenage niece, a hired hand, and his wife, all the grain they can produce requisitioned by the Confederate Army. It’s an uneasy life in the Shenandoah Valley, the territory frequently changing hands, control swinging back and forth like a pendulum between North and South, and Libby awakens every morning expecting to see her land a battlefield.

Ariadne, Princess of Crete, grows up greeting the dawn from her beautiful dancing floor and listening to her nursemaid’s stories of gods and heroes. But beneath her golden palace echo the ever-present hoofbeats of her brother, the Minotaur, a monster who demands blood sacrifice. When Theseus, Prince of Athens, arrives to vanquish the beast, Ariadne sees in his green eyes not a threat but an escape. Defying the gods, betraying her family and country, and risking everything for love, Ariadne helps Theseus kill the Minotaur.

In a shabby house, on a shabby street, in the new capital of Madrid, Luzia Cotado uses scraps of magic to get through her days of endless toil as a scullion. But when her scheming mistress discovers the lump of a servant cowering in the kitchen is actually hiding a talent for little miracles, she demands Luzia use those gifts to improve the family's social position.

From her cell in a mysterious convent, a woman writes the story of her life in whatever she can find—discarded ink, dirt, and even her own blood. A lower member of the Sacred Sisterhood, deemed an unworthy, she dreams of ascending to the ranks of the Enlightened at the center of the convent and of pleasing the foreboding Superior Sister. Outside, the world is plagued by catastrophe—cities are submerged underwater, electricity and the internet are nonexistent, and bands of survivors fight and forage in a cruel, barren landscape. Inside, the narrator is controlled, punished, but safe.

Jane has high hopes her life is about to turn around. After years of living precariously, she, her painter husband, Lenny, and their two kids have landed a stint as house sitters in a friend’s luxurious home high in the hills above Los Angeles, a gig that coincides magically with Jane’s sabbatical. If she can just finish her latest novel, Nusu Nusu, the centuries-spanning epic Lenny refers to as her “mulatto War and Peace,” she’ll have tenure and some semblance of stability and success within her grasp. But things don’t work out quite as hoped.