As Allied bombs rain down on Torino in the autumn of 1942, Stella Costa’s mother sends her to safety with distant relatives in a Tuscan villa. There, Stella finds her family tasked with a great responsibility: hiding nearly 300 priceless masterpieces from Florence, including Botticelli’s famous Primavera. With the arrival of German troops imminent, Stella finds herself a stranger in her family’s villa and she struggles to understand why her aunt doesn’t like her. She knows it has something to do with her parents.

Florence, 1500. Fresco painter Jacopo Torni longs to make his mark in the world. But while his peers enjoy prestigious commissions, his meager painting jobs are all earmarked to pay down gambling debts. When Jacopo hears of a competition to create Florence's greatest sculpture, he pins all his hopes on a collaboration with his boyhood companion, Michelangelo Buonarroti. But will the frustrated artist ever emerge from the shadow of his singularly gifted friend?

In the summer of 1943, Eva Brunner is taking photographs of Nazi-looted art hidden in the salt mines of the Austrian hinterland. Across the ocean in Connecticut, Josephine Evans is working as a humble typist at the Yale Art Gallery. When both women are called to Italy to contribute to the war effort, neither imagines she will hold the fate of some of the world’s greatest masterpieces torn from the Uffizi Galleries and other Florentine art collections in her hands.

Milan, 1492: When a 16-year-old beauty becomes the mistress of the Duke of Milan, she must fight for her place in the palace—and against those who want her out. Soon, she finds herself sitting before Leonardo da Vinci, who wants to ensure his own place in the palace by painting his most ambitious portrait to date. Munich, World War II: After a modest conservator unwittingly places a priceless Italian Renaissance portrait into the hands of a high-ranking Nazi, she risks her life to recover it, working with an American soldier, part of the famed Monuments Men team, to get it back.

Venice, 1510. Maria Bartolini wants nothing more than to carry on her father's legacy as a master gilder. Instead, her father has sent her away from the only home she's ever known to train as an apprentice to Master Trevisan, a renowned painter. Maria arranges to leave the painter's workshop to return to her family workshop and to a secret lover waiting for her back home. But the encroaching Black Death foils her plans.... When the painter's servants uncover the real reason why Maria has been sent away to train with Master Trevisan, they threaten to reveal a secret.