Midwife Patience Murphy has a gift: a talent for escorting mothers through the challenges of bringing children into the world. Working in the hardscrabble conditions of Appalachia during the Depression, Patience takes the jobs that no one else wants, helping those most in need - and least likely to pay. She knows a successful midwifery practice must be built on a foundation of openness and trust - but the secrets Patience is keeping are far too intimate and fragile for her to ever let anyone in.

For nearly 200 years, women in Ashley Tolliver's family have practiced the art of midwifery in their mountain community. Now she wants to take her skills a step further, but attending medical school means abandoning those women to whom she has dedicated her life, the mountains she loves, and the awakening of her heart.

Graduate student Beth Winslow was sure she was ready to navigate the challenges of becoming a surrogate. But when early tests indicate possible abnormalities with the baby, Beth is unprepared for the parents' decision to end the pregnancy - and for the fierce love she feels for this unborn child. Desperate, she flees the city and seeks refuge at Hopen Haus, a home for unwed mothers deep in a Tennessee Mennonite community.

Ana Kaminski is pushed through the iron gates of Auschwitz beside her frightened young friend Ester Pasternak. As they reach the front of the line, Ana steps forward and quietly declares herself a midwife--and Ester her assistant. Their arms are tattooed and they’re ordered to the maternity hut. Holding an innocent newborn baby, Ana knows the fate of so many are in her hands and vows to do everything she can to save them.

Midwife Kim Osterholzer ushers listeners behind the doors of Amish homes as she recounts her adventures answering God's call to the craft of midwifery. Kim chronicles her nine-year apprenticeship grappling with the nuances and idiosyncrasies of homebirth. She recounts the beauty and painstaking effort of those early years spent catching babies by the light of crackling woodstoves, oil lamps, and lanterns. Every birth enthralled her, whether it involved halting hemorrhages, sharing breath with tiny lungs, or bouncing through wild rides in ambulances.

The McKenzie women, empowered with a formidable history rooted in the foothills of Appalachia, have passed down their folk-healing wisdom through generations. Rosalee, the last living headstrong daughter in Granny McKenzie’s line, soaked up everything she could about the secrets of the forest before a series of tragedies left her alone, without the protection of the women who came before her.

Occupied Poland, 1942: Despite the constant presence of German soldiers in her village, Emilia is allowed certain freedoms as a midwife—the most precious is innocently cycling past Nazi checkpoints to the homes of expectant mothers on her rounds. But Emilia has a secret: for years she’s also been visiting the hidden Jewish mothers and working for the resistance…until she is betrayed.

Dear Anna, What I have to tell you is difficult to write, but I know it will be far more difficult for you to hear, and I'm so sorry. The unfinished letter is the only clue Tara and Emerson have to the reason behind their close friend Noelle's suicide. Everything they knew about Noelle - her calling as a midwife, her passion for causes, her love for her friends and family - described a woman who embraced life. Yet there was so much they didn't know. With the discovery of the letter and its heartbreaking secret, Noelle's friends begin to uncover the truth about this complex woman who touched each of their lives.

Virginia Howes was a mother of four doing the ironing when she had a revelation. Still broody, but not really wanting to add to her family, she realised that becoming a midwife was her true vocation. It was a long journey to get the education and qualifications she needed, especially with a young family, but she was determined and never doubted her decision. Following her training, she spent three years working within the NHS, but her naturally independent spirit fought against the constraints of the system and 12 years ago she decided to set up on her own.

In the slums of 1880s New York, Una Kelly has grown up to be a rough-and-tumble grifter, able to filch a pocketbook in five seconds flat. But when another con-woman pins her for a murder she didn't commit, Una is forced to flee. Running from the police, Una lies her way into an unlikely refuge: the nursing school at Bellevue Hospital.

Moments after Lisbeth is born, she’s taken from her mother and handed over to an enslaved wet nurse, Mattie, a young mother separated from her own infant son in order to care for her tiny charge. Thus begins an intense relationship that will shape both of their lives for decades to come. Though Lisbeth leads a life of privilege, she finds nothing but loneliness in the company of her overwhelmed mother and her distant, slave-owning father.

Untrue things are rumored of May Rose, but it's true she's too pretty for her own good. Her husband has disappeared, and now she's on her own in a rough town ruled by one of the lumber companies logging the last of West Virginia's virgin forest. The year is 1899, and a woman alone has few options.

The folks in the Kentucky Appalachians are scraping by. Coal mining and hardscrabble know-how are a way of life for these isolated people. But when Amanda Rye, a young widowed mother and traveling packhorse librarian, comes through a mountain community hit hard by the nation’s economic collapse, she brings with her hope, courage, and apple pie.

1838: Northumberland, England. Longstone Lighthouse on the Farne Islands has been Grace Darling’s home for all of her 22 years. When she and her father rescue shipwreck survivors in a furious storm, Grace becomes celebrated throughout England, the subject of poems and plays. 1938: Newport, Rhode Island. Nineteen-years-old and pregnant, Matilda Emmerson has been sent away from Ireland in disgrace. She is to stay with Harriet until her baby is born. As a deadly hurricane approaches, two women, living a century apart, will be linked forever by their instinctive acts of courage and love.

When she fell asleep, the world was doomed. When she awoke, it was dead. In the wake of a fever that decimated the earth's population - killing women and children and making childbirth deadly for the mother and infant - the midwife must pick her way through the bones of the world she once knew to find her place in this dangerous new one. Gone are the pillars of civilization. All that remains is power - and the strong who possess it.