J. Jonah Jameson, the publisher of the Daily Bugle, has denounced Spider-Man from the beginning, convincing New Yorkers to see him as a criminal and a menace. But when a robot attack on Manhattan injures Peter Parker's students and Jameson blames Spider-Man, their feud takes on a personal dimension.

Brian Timilty is running for mayor on an anti-superhero ticket, and the amazing Spider-Man is his biggest target. But Timilty is secretly the pawn of Tyler Stewart, a wealthy businessman seeking to take over New York's mobs. To ensure his success, Stewart hires two of Spider-Man's deadliest foes, Electro and the Rhino, and executes a plan guaranteed to keep the wall-crawler from interfering with his grand designs: He frames Spider-Man for a grisly murder! Forced into hiding, Spider-Man must find a way to clear his name without being shot on sight, for he is wanted dead or alive.

When Eddie Brock becomes biologically linked to a bizarre alien symbiote, the two share a common goal. At first, they seek to squash their arch-foe Spider-Man. But after repeated attempts, Venom reaches an uneasy truce with the web-spinner. Brock leaves New York and heads west to San Francisco, the city of his birth, eager to put trouble behind him, but trouble has different ideas. Brock commits himself to becoming a defender of the innocent, but he's a six-foot-three-inch, 260 lb. figure with bulging muscles and fangs like a shark. Venom quickly draws attention.

Peter Parker is caught in a complicated web. Working in a cutting-edge laboratory, he's a young scientist who's trying to make a difference. Yet he's constantly burdened by the responsibilities of his second career as the crime-fighting Spider-Man. Wilson Fisk - the so-called Kingpin of Crime - has returned to New York, establishing himself publicly as an altruistic entrepreneur and philanthropist. Spider-Man knows better, but he can't uncover Fisk's scheme, which, if executed, will make the crime lord too big to fail.

The X-Men and Spider-Man must work together to stop the destruction of the multiverse in an adventure through the past, present, and future. Dinosaurs, knights, gunslingers, World War II heroes, old friends turned enemies, and future versions of themselves await them on this incredible adventure.

In a Manhattan warehouse, an innocent man has been murdered during a mysterious crime. Evidence points to the involvement of Venom - the alien symbiote obsessed with Spider-Man's destruction. Yet Venom has always safeguarded innocent lives. Has Venom gone completely around the bend, or is there another suspect? Spider-Man thinks there is more to the crime than meets the eye. The specter of the Hobgoblin, one of Spider-Man's nastiest foes, falls on a series of thefts and leads the web-slinger to a deadly secret that may cause New York's destruction.

In the spirit of the popular Marvel comic book, this exciting new anthology has over a dozen original tales that span the career of the amazing Spider-Man. Stan Lee, Spidey's co-creator, and Kurt Busiek, the award-winning writer of the Untold Tales of Spider-Man comic book, present these new stories from his earliest days as a costumed hero and beyond.

Millionaire industrialist Tony Stark has rejected the lucrative munitions trade that put his company on the map. But he can’t just turn away when the antiterror organization known as S.H.I.E.L.D. asks him for help in its battle against the sinister forces of HYDRA. As the next step in its quest for global domination, the international terrorist cabal is plotting to use cutting-edge technology in a devastating attack on New York City. The source of their advanced weaponry: Stark Industries.

When a baddie drops out of a sky-high window (Did he jump - heh heh - or was he pushed?), Daily Bugle publisher J. Jonah Jameson wants Spider-Man to take the rap. Has the wall-crawler come to the end of his rope? Does his life hang by a slender thread? To swing clear of this one, he's got to snoop on an international oil conference. There's blackmail! Radioactivity! And a welcoming committee of death-dealing arch-villains!

Born to a rarified breed of Russian aristocracy, Kraven the Hunter had stalked and killed every animal known to man and considered himself the world's best big-game hunter. It was this confidence that brought him to New York years ago, in an obsessive quest to hunt what he considered the city's greatest prey: Spider-Man. But his target eluded him time and again, mocking him at every turn.

MODOK, the Mental Organism Designed Only for Killing, is the product of the corrupt scientists of A.I.M (Advanced Idea Mechanics). Iron Man learns that MODOK has turned his back on his creators, destroying an A.I.M. undersea lab, leaving only one devastated survivor. But MODOK's fearsome plan involves more than taking revenge... Now Iron Man must recruit his fellow heroes War Machine, Captain America, and the Black Panther to help him stop MODOK from gathering the materials he needs to create the ultimate weapon - a weapon that could spell humanity's doom!

Cyclops and Emma Frost re-form the team with the express purpose of "astonishing" the world. But when breaking news regarding the mutant gene unexpectedly hits the airwaves, will it derail their new plans before they even get started? As demand for the "mutant cure" reaches near-riot levels, the X-Men go head-to-head with the enigmatic Ord, with an unexpected ally - and some unexpected adversaries - tipping the scales!

The Avengers journey into deep space, where they unite the intergalactic races against the Builders - deadly aliens who seek to destroy the known galaxy. While the heroes are gone, Thanos sets his sights on Earth, sending the Black Order to launch the assault. It falls to the other heroes of Earth - the Inhumans, the Black Panther, Namor the Sub-Mariner, Doctor Strange, the X-Men, and more - to defend Attilan, Wakanda, Atlantis, and the rest of the planet. To defeat Thanos, the defending forces will need to deploy a new weapon - one that may be as deadly as the invading force.

When millionaire industrialist and scientist Tony Stark puts on his gleaming high-tech armor, he becomes Iron Man! When Stark is kidnapped, his corporation must turn to another armored hero, and Stark's best friend, War Machine, to fulfill the ransom. And War Machine won't just take orders from kidnappers... Meanwhile, Stark is trapped in a cell with no hope of escape, forced to create a new suit of armor for his captor. Stark must use his genius to navigate a cyber-space maze, defeat a virtual-reality trap, and retrieve his own Iron Man armor.

Hydra has a synthetic pathogen that will make the entire human race dependent on them for the cure. A.I.M.'s newly developed nanotech compound to enslave humanity is dangerously close to contaminating the world's water supplies. Ultron is poised on the edge of Singularity, Earth's technology at his metallic fingertips. Dormammu has a plan to save the world - by claiming it as his own. The High Evolutionary is rewriting the human genome in a bid to turn humankind into a eugenic slave-race. Everybody wants to rule the world - and only the isolated Avengers can stop them.