"I’m a Stranger Here” could be the song title guiding Lizzie Baker’s life. In the five years she spent on Brown Mountain during the Civil War, Lizzie wanted nothing more than to find the light that transported her back in time and return to the 20th century. While fleeing from bushwhackers in 1864, Lizzie, her friend Abbie Collins, and fiancé Josh Hampton encounter a light Lizzie believes is hers. Hoping to get to safety, she pushes Abbie into the light, expecting Josh to follow. She and Abbie wake to find that this is not the Brown Mountain they remember.

In the waning years of the 19th century, Bessie Daniels grows up in the small town of Hot Springs in western North Carolina. Secure in the love of her father, resistant to her mother's desire that she be a proper Southern belle, Bessie is determined to forge her own way in life. Or, as her Cherokee great-grandmother Elisi puts it, to be a whistling woman. Life, however, has a few surprises in store for Bessie....

Memphis, 1939. Twelve-year-old Rill Foss and her four younger siblings live a magical life aboard their family’s Mississippi River shantyboat. But when their father must rush their mother to the hospital one stormy night, Rill is left in charge - until strangers arrive in force. Wrenched from all that is familiar and thrown into a Tennessee Children’s Home Society orphanage, the Foss children are assured that they will soon be returned to their parents - but they quickly realize the dark truth.

Worie Dressar is 17 years old when influenza and typhoid ravage her Appalachian Mountain community in 1877, leaving behind a growing number of orphaned children with no way to care for themselves. Worie’s mother has been secretly feeding several of these little ones on Sourwood Mountain. But when tragedy strikes, Worie is left to figure out why and how she was caring for them.

Orphaned during her passage from Ireland, young, white Lavinia arrives on the steps of the kitchen house and is placed, as an indentured servant, under the care of Belle, the master's illegitimate slave daughter. Lavinia learns to cook, clean, and serve food while guided by the quiet strength and love of her new family. In time Lavinia is accepted into the world of the big house, caring for the master's opium-addicted wife and befriending his dangerous yet protective son. She attempts to straddle the worlds of the kitchen and big house, but her skin color will forever set her apart.

Tessa O’Connor is tired of the high society lifestyle, and the pressure is on for her to marry a wealthy man. Fearful of becoming trapped in a life that would make her increasingly miserable, she decides to try the mail-order bride approach.

Moments after Lisbeth is born, she’s taken from her mother and handed over to an enslaved wet nurse, Mattie, a young mother separated from her own infant son in order to care for her tiny charge. Thus begins an intense relationship that will shape both of their lives for decades to come. Though Lisbeth leads a life of privilege, she finds nothing but loneliness in the company of her overwhelmed mother and her distant, slave-owning father.

Declan O'Bryan left Ireland to seek his fortune in the New World, but the journey was long for a man without a penny to his name. It took years of back-breaking work as a sailor and a journeyman for him to finally reach Montana, and to have enough money to his name to earn the title of proud homesteader. There's only one thing missing from his life now, and, unlike the boys in town, he's not convinced a man should find a wife in a catalog, the same way he buys a plow.

Francine Howard has her life all mapped out until the soldier she planned to marry at WWII's end writes to tell her he's in love with a woman in England. Devastated, Francine seeks a fresh start in the Appalachian Mountains, training to be a nurse midwife for the Frontier Nursing Service. Deeply affected by the horrors he witnessed at war, Ben Locke has never thought further ahead than making it home to Kentucky. His future shrouded in as much mist as his beloved mountains, he's at a loss when it comes to envisioning what's next for his life.

Ruby Graves, a young girl in Depression-era Alabama, faces the hardships of poverty and loss with as much faith as she can muster. At only the age of 13, she's already lost a younger brother to illness and now faces losing both her father and the boy who's stealing her heart to illnesses as well. Armed with her beloved scriptures, she prays daily for their healing, only to have her tender faith shattered by her father's death.

Susan Farr loses her parents and her home in one swoop. She takes her horse and rides to Independence, Missouri, to join a wagon train and start a new life. Mike Todd, the wagon master, doesn’t allow single women to have their own wagons. It causes fights and distractions. Susan solves her problem by marrying Clancy Willis in name only. Unfortunately, Clancy’s true nature doesn’t take long to show, and Susan finds herself married to a drunkard.

Lillian Porter has always wanted to fulfill her mother's dream of going west, so when she hears about a nanny position in Angels Camp, California, she defies her grandfather and takes a chance on a new future. But she quickly wonders if she made the right choice. There are rumors in town that her new employer, Woodward Colton, caused the death of his wife. This accusation doesn't match the man Lillian comes to know.

To escape a forced marriage, Cora Taylor travels from England to the Blue Ridge Mountains in search of her brother, who is working as a teacher in a mission school. She hopes to find a place where her nursing skills and independent ideas will be accepted and appreciated, but nothing prepares her for the wild mixture of isolation, community, brokenness, and hope within these mountains … or in the person of Jeb McAdams.

Amid the aftermath of the Civil War, Georgie O'Rourke, the last surviving member of her family, decides her only choice is to leave her beloved state of Tennessee by answering a mail-order bride advertisement. With only a few items of rag, like clothing, she travels the Southwest Trail by covered wagon to meet up with her groom in Texas. Captain Parker Eastman, formally of the Confederate Army, travels from his cattle ranch to the Southwest Trail to intercept a woman his mother hired as a companion. He soon finds out that Georgie traveled to Texas to become his wife.

In 1945, when Billy May was 14 years old and alone, three local boys witnessed an incident in which Billy May's sexuality was called into question. Determined to teach her a lesson she would never forget, they orchestrated a brutal attack that changed the dynamics of the tiny coal mining village of Cedar Hollow, West Virginia forever. Thirty years after the brutal attack, living in solitude on top of Crutcher Mountain, Billy May discovers the hideout of a young girl - a girl who just happens to be the daughter of one of the boys who attacked Billy May so long ago.