On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

Through public triumphs and private sorrows, the men in the Sisters' lives - husbands, friends, colleagues, and lovers - have offered invaluable aid and support. In the process, they've become an informal brotherhood of their own, able to relate to the unique challenges and rewards of life among the vigilantes.

Teresa "Toots" Amelia Loudenberry has crammed a great deal of living - not to mention eight much-loved husbands - into her varied and rewarding life. Newly single, Toots is ready to taste life again, and fate has just handed her the perfect opportunity.

For Melanie Drake, school guidance counselor in a small Virginia town, the day’s challenges typically involve a playground scuffle or a student skipping school. It’s worlds away from her previous career as a vital part of the Office of Special Investigations. There, she devoted herself heart and soul to covert operations, the riskier the better.

Luna Bodman always looks forward to a new shipment of furniture at the restoration shop. Her brother, Cullen, has a knack for finding discarded pieces with an intriguing history, and Luna likes to sit with each item to see if she can feel any kind of vibrations. Usually, Cullen does his thing while Luna does hers, but the arrival of an old armoire triggers a reaction in Luna that’s impossible to ignore. From the moment Luna wiggles inside the armoire and closes her eyes, she feels an overpowering and disturbing sensation.

When Sasha receives a call from her old university friend Gabby inviting her to spend Christmas at Gabby’s remote Scottish lake house, Sasha knows she shouldn’t go. Twelve years ago, on Christmas Eve, when Sasha and her five closest friends were celebrating the festive season, something truly horrific happened that would change the course of their friendship forever. Something that meant Sasha hasn’t spoken to any of them since that night.

After the killing of a prominent mob lawyer, NYPD homicide detectives Jacob Jackson and Caitlin Grimes start receive chilling, written “rules” for how to commit the perfect murder. "Rule number one for the perfect murder: Evidence is your enemy. Leave none behind." Jackson (Reid Scott) and Grimes (Cobie Smulders) race to find the killer, setting them on a collision course with the city’s crime underbelly, and a perpetrator who seems happy to toy with them. “Rule number two. No crimes of passion. The perfect murder is always business, never pleasure.”

England, 1914. The world is at war. Captain Hastings, injured and shaken, is invited to Styles Court to recover. It’s a grand old country house - the family home of his old friend - and a perfect haven. Or so it seems. But in the blistering summer heat, trouble is afoot. Simmering tensions are tearing the family apart, and it all comes to a head in the most horrifying way.

Jenny sits in the same seat on the same train every week, seeing familiar faces come and go. Until a chance encounter shatters her world. Sixteen years ago, Jenny survived a traumatic ordeal that left her best friend, Susie, missing and presumed dead. The world has its theories about what happened to Susie Patterson, and one of those theories points the finger at Jenny. Now she lives a quiet life, volunteering at a crisis helpline while trying to deal with her own anxiety and the true crime fans obsessed with finding her missing friend.

Lowen Ashleigh is a struggling writer on the brink of financial ruin when she accepts the job offer of a lifetime. Jeremy Crawford, husband of best-selling author Verity Crawford, has hired Lowen to complete the remaining books in a successful series his injured wife is unable to finish. Lowen arrives at the Crawford home, ready to sort through years of Verity's notes and outlines, hoping to find enough material to get her started. What Lowen doesn't expect to uncover in the chaotic office is an unfinished autobiography Verity never intended for anyone to read.

Kidnappers grabbed Jenna in broad daylight, right in front of her children and their horrified classmates. Her family was issued an insane ransom demand: $25 million in cash and jewels, payable by the end of the school day, otherwise they’ll never see her again. As Jenna’s mother scrambles to gather the money, detectives Mo Butler and George Ortega follow the trail of the kidnappers, which will lead them through a sordid landscape of jealous lovers, broken dreamers, and twisted schemers. But every second counts, and there’s one thing Jenna Wade doesn’t have: very much time.

Jazz Bashara is a criminal. Well, sort of. Life on Artemis, the first and only city on the moon, is tough if you're not a rich tourist or an eccentric billionaire. So smuggling in the occasional harmless bit of contraband barely counts, right? Not when you've got debts to pay and your job as a porter barely covers the rent. Everything changes when Jazz sees the chance to commit the perfect crime, with a reward too lucrative to turn down.

Everyone thinks my husband is dead. Just like we planned. Eleven years ago, my husband disappeared. Eleven long hard years I waited, my heart breaking for our son, who didn’t know his father was coming back. Today, my hands shake as I try to understand what I’ve just learned: my husband has a new wife. This wasn’t part of our plan. Eleven years ago, my husband made a terrible mistake. I sacrificed everything to help him fix it. But now he’s put our son and me in danger again. We had a plan. He broke the rules. But who will pay the price?

When Heather McKinley dreamed of becoming a doctor, she imagined curing sick kids and sporting pink stethoscopes. She never anticipated the sleepless nights, grueling exams, and endless labs. And she certainly never knew that her medical school earned the nickname Dead Med thanks to the tragic history of students overdosing on illegal drugs. But Heather would never consider doing anything like that. That is, until her longtime boyfriend dumps her, she finds herself failing anatomy, and her world starts to crumble.

Cassie thinks she has met the perfect man. Joel is sweet, handsome, romantic, and best of all, he’s crazy about Cassie. She thinks she’s found the guy she’ll spend the rest of her life with. Have children with. Grow old with. Yes, she knows about his perfect ex-girlfriend, Francesca. The beautiful, brilliant chef, beloved by all his friends. But she thinks Francesca is out of the picture. She thinks Francesca is gone for good. Think again, Cassie.

On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

Luna Bodman always looks forward to a new shipment of furniture at the restoration shop. Her brother, Cullen, has a knack for finding discarded pieces with an intriguing history, and Luna likes to sit with each item to see if she can feel any kind of vibrations. Usually, Cullen does his thing while Luna does hers, but the arrival of an old armoire triggers a reaction in Luna that’s impossible to ignore. From the moment Luna wiggles inside the armoire and closes her eyes, she feels an overpowering and disturbing sensation.

Anna Campbell is ready to take her first tentative steps back into the world after widowhood. On a singles cruise, she meets divorced professor Ryan Robertson, and the sparks between them are undeniable. Back home in West Texas, Anna and Ryan continue their romance, and Anna decides it’s time for their families to meet. But the idyllic relationships Anna is hoping for are quickly thrown into doubt. And as the situation grows more desperate, Anna must reach deep within and draw on all her courage and self-reliance to fight for the family and home she deserves...

For Melanie Drake, school guidance counselor in a small Virginia town, the day’s challenges typically involve a playground scuffle or a student skipping school. It’s worlds away from her previous career as a vital part of the Office of Special Investigations. There, she devoted herself heart and soul to covert operations, the riskier the better.

A brilliant movie career, two adoring husbands - none of it is enough to erase the memory of Ariel Hart's one true love. Back when she was plain, shy Aggie Bixby, a dark-eyed young man named Felix touched her heart...then vanished from her life. Now, she's about to do something shocking and outrageous - sell her house and leave Hollywood behind. Making her new home in the quiet town of Chula Vista, she meets Lex Sanders, a wealthy rancher and breeder of Arabian horses.

Mateo Castillo is a rising star chef on the Manhattan culinary scene. But just as he’s about to reap the rewards of his skill and hard work by being featured on a major TV cooking competition, Mateo collapses in his restaurant’s kitchen—and regains consciousness in a hospital emergency room. If it weren’t for a security guard finding him in time, Mateo would have bled to death. The cause of his sudden illness is as mysterious as it is worrying, and Mateo and his family undergo a battery of genetic tests. Yet the answers that start to emerge only raise more questions.

Teresa "Toots" Amelia Loudenberry has crammed a great deal of living - not to mention eight much-loved husbands - into her varied and rewarding life. Newly single, Toots is ready to taste life again, and fate has just handed her the perfect opportunity.

Satisfied with her life and a new relationship, Abby Mitchell is most happy to be reunited with her sister, who was separated from her after their parents died. The siblings are planning a sumptuous party, unaware that an uninvited guest is coming, one who'll do anything to help keep the past hidden.

Professional mountaineer Lily is building a new life for herself - in ways she never would have expected. She's traded the mountain wilderness of Wyoming for the lush river country of the deep South, where she is busy restoring a fine old Natchez, Mississippi house. And she's rediscovered happiness with Matt Starr, the man she has always loved. But Lily's dreams for the future are suddenly threatened when Matt disappears without a trace.

At Ridgewood High, Amy, Frankie, Rachael, and Nina formed a deep bond. Now, 15 years after leaving school behind, they’re back for a reunion, laughing, reminiscing, and chatting how much has changed - and how much hasn’t. But Frankie has an idea to help solve that: a singles cruise for the holidays.

Raised on her father's South Carolina plantation, Callie Parker wanted for nothing, and now she is about to marry wealthy local scion Wyn Archer. But her wedding wouldn't be complete without the three people she grew up with under the sheltering branches of the angel oaks at Parker Manor.

It came out of the blue. A half-million dollars on graduation day. For Annie Daisy Clark, it was the capital she needed to start a business. Vowing to pay back every penny of it one day, she kept the bag of cash she’d found, and never looked back. Ten years later, Annie’s investment has paid off. The owner of a successful chain of elegant coffee bars, she is blissfully engaged and about to return to Boston for her ten-year college reunion. She also begins making good on her promise. But just as Annie’s life seems complete, the dark history of the money returns to haunt her.

At 29, Alison Marshall is ready to find a place to call home. With no family and no ties, she’s drifted from one small Florida town to another since high school, working odd jobs, saving hard, and building a nest egg. Once she finds the right place to settle down, she’ll know. And when she reaches beautiful Palmetto Island, she thinks she may have found it. The small, close-knit island community seems to have everything Alison needs. On a hunch, she contacts the island’s only realtor, and learns that an old beach house is on the market.

Young Billie Ames naively fell for the exciting pilot Moss Coleman at the Philadelphia Navy Yard during World War II. Within a few months, she was pregnant, married, and traveling across the country to Austin...to the 250,000-acre spread known as Sunbridge and into the tantalizing world of the Texas rich. In a vast land dominated by the industrious Colemans, Billie fights to maintain control of her life and her marriage.

Back in college, Jane Lewis would have given anything to be like homecoming queen Connie Bryan. Instead she was just Plain Jane - overweight, frumpy, and painfully shy. That was then. Today, a lovely and confident Dr. Jane Lewis has a thriving psychotherapy practice, her own radio talk show, a beautiful old Louisiana mansion, and her affectionate, nutty dog, Olive, to keep her company. The only thing missing is someone to share her life.