When Frank Devlin walks into Justin Wright's office, the renowned New York City clinical psychiatrist makes the decision to take on one of the most challenging cases of his career. Justin is determined to help Frank, a young man with multiple personalities (“alters”), live a happier, more fulfilling life. Little does he know that Frank and his alters are secretly weaving themselves into Justin’s life in ways that will affect the Wright family forever.

Architect Carter Grady is constructing his most prized design - a family. Two years after marrying his deceased best friend’s wife, Tori, he’s ready to officially adopt her two sons, independent Daniel, 12, and the sweet five-year-old Nathan. All he needs to do is sign the legal paperwork. But a phone call changes everything. A one-night stand from over a decade ago died in a freak accident and Carter now learns two things: the random stranger’s name...and that they share a 10-year-old son, Frances.

Angela is beautiful and charismatic on the outside. But on the inside, evil rages and she's determined to get anyone and anything she wants. And now with her biological clock ticking, she seduces her old friend Philip, and his partner Jonathan, into having a child with her through artificial insemination.

In the middle of the night, in a house on a quiet street in suburban Minneapolis, intruders silently murder Luke Ellis' parents and load him into a black SUV. The operation takes less than two minutes. Luke will wake up at The Institute, in a room that looks just like his own, except there's no window. And outside his door are other doors, behind which are other kids with special talents - telekinesis and telepathy - who got to this place the same way Luke did: Kalisha, Nick, George, Iris, and 10-year-old Avery Dixon.

Alex Armstrong has changed everything about herself—her name, her appearance, her backstory. She’s no longer the terrified teenager a rapt audience saw on television, emerging in handcuffs from the quiet suburban home the night her family was massacred. That girl, Alexandra Quinlan, nicknamed Empty Eyes, was accused of the killings, fought to clear her name, and later took the stand during her highly publicized defamation lawsuit that captured the attention of the nation. It’s been ten years since, and Alex hasn’t stopped searching for answers about the night her family was killed.