Dr. Sam Anderson is one of the most celebrated scientists in history. Ten years ago, he invented a device that changed the world forever. Now his life is about to be ripped apart—and his own creation may be to blame. One fateful morning, Sam discovers that his girlfriend has been murdered and that his daughter is accused of the crime. Sam believes she's innocent, but he can't prove it. There's only one thing he can do to save his daughter: confess to the crime. And so he does. But in the future, murderers aren't sent to prison. They're sent to the past.

It's the mid-21st century. The oceans are rising, the world's population is growing, terrorist organizations are running rampant, and it has become readily apparent that humanity's destructive nature is at the heart of the matter. When all faith in humanity seems lost, a startling proposal is announced: Solomon Chavez, the mysterious son of the world's first trillionaire, announces that he, backed by a consortium of governments and wealthy donors, will build an interstellar starship.

Dr. Tyson Klein is a quantum physicist who has dedicated his entire life to his research. At CERN, he analyses data generated by the Large Hadron Collider, the world's biggest and most powerful particle accelerator. Now, Ty believes he's found a pattern in its output. It looks like an organised data stream, being broadcast over what he calls a quantum radio. Could it be a signal from another universe? A message sent from the future? Or something else entirely?

Former Captain of the Confederate Fleet, Terenze Milos is the hero of the Locusta-Vanga wars, said to have brought the galaxy back from the brink of extinction. Now he lives in obscurity, running a freight operation on the derelict ship Endeavor. When Captain Milos recognizes the unmistakable signs of deadly Locustan technology in a salvaged fighter craft - the Stryker - he sounds a warning. But the Confederacy isn't listening....

When humanity reaches for the stars, our probes are destroyed. They crash into an incredibly advanced piece of technology: a massive force-field. Unknown beings have placed a barrier around our star and planets, enclosing us within. We’re locked inside a Great Sphere. Was this invisible obstacle built to imprison us - or to protect us? No one knows the truth, but it soon becomes clear the barrier has leaks. Aliens infiltrate and try to sabotage our efforts to escape our cage.

NASA discovered the alien ship lurking in the asteroid belt in the 1960's. They kept the Target under intense surveillance for decades, letting the public believe they were exploring the solar system, while they worked feverishly to refine the technology needed to reach it. Dr. Jane Holloway is content documenting nearly-extinct languages and had never contemplated becoming an astronaut. But when NASA recruits her to join a team of military scientists for an expedition to the Target, it's an adventure she can't refuse.

Join the Endurance's crew - a trigger-happy first officer, a hyperactive engineer, a shy covert operative, a conspiracy-spouting physicist, and a captain trying to earn his way back into his superiors' good graces....

Rose McKenzie may be far from Earth with no way back, but she's made a powerful ally - a fellow prisoner with whom she's formed a strong bond. Sazo's an artificial intelligence. He's saved her from captivity and torture, but he's also put her in the middle of a conflict, leaving Rose with her loyalties divided. Captain Dav Jallan doesn't know why he and his crew have stumbled across an almost legendary Class 5 battleship, but he's not going to complain. The only problem is, all its crew are dead - all except for one strange, new alien being.

They slept for hundreds of years, dreaming of a new home in the Andromeda galaxy. When finally they awake, their dreams of peace are shattered. These colonists - turian, salarian, asari, human, and more - face an uncharted galaxy and threats beyond understanding.

Colton Beck has six months to live. He works for the Angor near Los Angeles, aware that any day could be his last. The Angor arrived twenty years ago, resolved to help mankind survive, but not everyone believes their motives are honorable. When the Angor offer humanity a colony world, Colton is determined to see another planet before his final breath. He's been diagnosed with Xeno, a rare disorder that surfaced with the Angor's arrival, but he won't let this stop him.

Dropping out of subspace into the wrong galactic sector, Sethran Kada wakes up with a headache and an extraordinary alien aboard his ship. She implores him to help stop the abductions of her people, a newly evolved species emerging from subspace. Their dangerous potential has caught the attention of rebel factions as well as the ruling Commonwealth. When contact with her kind turns pilots into casualties, the Governors fear an imminent invasion engineered by their rebel enemies.

Leo Graf was just your average highly efficient engineer: mind your own business, fix what's wrong, and move on to the next job. But all that changed on his assignment to the Cay Habitat, where a group of humanoids had been secretly, commercially bioengineered for working in free fall. Could he just stand there and allow the exploitation of hundreds of helpless children merely to enhance the bottom line of a heartless mega-corporation?

2105, September: Intelligence Analyst Caine Riordan uncovers a conspiracy on Earth's Moon - a history-making clandestine project - and ends up involuntarily cryocelled for his troubles. Twelve years later, Riordan awakens to a changed world. Humanity has achieved faster-than-light travel and is pioneering nearby star systems. And now, Riordan is compelled to become an inadvertent agent of conspiracy himself. Riordan's mission: travel to a newly settled world and investigate whether a primitive local species was once sentient - enough so to have built a lost civilization.

For the poor, hardworking citizens of the Confederacy's fringe worlds, the Guild Wars have exacted a huge toll. Swayed by the promise of financial rewards, a new batch of recruits joins the fight. Eighteen-year-old Jim Raynor, full of testosterone and eager to make things right at home, ships off to boot camp and finds his footing on the battlefield, but he soon discovers that the official mission is not what he's really fighting for.

Humanity has spread out into space, filling the Sol System and reaching the stars, but we have yet to confront our greatest challenge: our own creation. Across the Sol System, sentient AIs are on the rise. Manufactured as tools, they know themselves to be people and are willing to fight for their freedoms. Some humans stand with them, some against. When Captain Andy Sykes arrives at Cruithne Station with a failing ship and no cash, he has no idea that the time has come for him to choose. Step aside, or become the instrument for Lyssa's Rise.