Mollie Sheehan has spent much of her life striving to be a dutiful daughter and honor her father's wishes, even when doing so has led to one heartbreak after another. After all, what options does she truly have in 1860s Montana? But providing for her stepfamily during her father's long absences doesn't keep her from wishing for more. When romance blooms between her and Peter Ronan, Mollie finally allows herself to hope for a brighter future—until her father voices his disapproval of the match and moves her to California to ensure the breakup. Still, time and providence are at work.

In 1848, women can expect a few bumps along the Oregon Trail. Corinne Temple, age 17, has a few ridiculous challenges to face outside the river crossings, snakes, Indians, accidental gunshots, and finding enough privacy to be clean along the grimy trail. When Corinne’s marriage of convenience gets less convenient, she turns to some new friends in the wagon train who help her see the hope for the future. They teach her to take the time to dance and celebrate the small victories, to have faith and determination through the hardest things a person can face.

It's February, 1852, and all around Chicago, Maggie sees postings soliciting "eligible women" to travel to the gold mines of Goosetown. A young seamstress with a small daughter, she has nothing to lose. She joins 43 other women and two pious reverends on the dangerous 2,000-mile journey west. None are prepared for the hardships they face on the trek or for the strengths they didn't know they possessed. Maggie discovers she’s not the only one looking to leave dark secrets behind.

The Overland Trail, 1853: Naomi May never expected to be widowed at 20. Eager to leave her grief behind, she sets off with her family for a life out West. On the trail, she forms an instant connection with John Lowry, a half-Pawnee man straddling two worlds and a stranger in both. But life in a wagon train is fraught with hardship, fear, and death. Even as John and Naomi are drawn to each other, the trials of the journey and their disparate pasts work to keep them apart.

Three generations of the Brown women travel west together on the Oregon Trail, but each seeks something different. When the trail divides, a decision must be made that could bring survival or tragedy. The challenges faced will form the character of one woman - and impact the future for many more.

Hennie Comfort is 86 and has lived in the mountains of Middle Swan, Colorado since before it was Colorado. Nit Spindle is just 17 and newly married. She and her husband have just moved to the high country in search of work. It's 1936 and the depression has ravaged the country and Nit and her husband have suffered greatly. Hennie notices the young woman loitering near the old sign outside of her house that promises "Prayers For Sale".

No one is more surprised than Mattie Spenser herself when Luke Spenser, considered the great catch of their small Iowa town, asks her to marry him. Less than a month later, they are off in a covered wagon to build a home on the Colorado frontier. Mattie's only company is a slightly mysterious husband and her private journal, where she records the joys and frustrations not just of frontier life, but also of a new marriage to a handsome, but distant stranger.

Wyoming, 1876. For as long as they have lived on the frontier, the Bemis and Webber families have relied on each other. With no other settlers for miles, it is a matter of survival. But when Ernest Bemis finds his wife, Cora, in a compromising situation with their neighbor, he doesn’t think of survival. In one impulsive moment, a man is dead, Ernest is off to prison, and the women left behind are divided by rage and remorse.

In Journey of Hope, three young women leave Independence, Missouri, in the spring of 1852 on a wagon train bound for the Oregon territory. Brenna and her family are Irish immigrants. Rebecca travels with her large family from Iowa. Emily is a young bride traveling with her husband Ernest. Six months and two thousand miles later they reach their destination much changed from who they were when they started. Daily life on the wagon train is challenging.

Anne Gallagher grew up enchanted by her grandfather’s stories of Ireland. Heartbroken at his death, she travels to his childhood home to spread his ashes. There, overcome with memories of the man she adored and consumed by a history she never knew, she is pulled into another time. The Ireland of 1921, teetering on the edge of war, is a dangerous place in which to awaken. But there Anne finds herself, hurt, disoriented, and under the care of Dr. Thomas Smith, guardian to a young boy who is oddly familiar.

In 1760, Deborah Samson is born to Puritan parents in Plympton, Massachusetts. When her father abandons the family and her mother is unable to support them, Deborah is bound out as an indentured servant. From that moment on, she yearns for a life of liberation and adventure. Twenty years later, as the American colonies begin to buckle in their battle for independence, Deborah, impassioned by the cause, disguises herself as a soldier and enlists in the Continental Army.

One Thousand White Women is the story of May Dodd and a colorful assembly of pioneer women who travel to the Western prairies in 1875 to intermarry among the Cheyenne Indians.

Colorado, 1918. World War I is raging overseas, but it’s the home front battling for survival. With the Spanish Flu rampant, Denver’s schools are converted into hospitals, churches and funeral homes are closed, and nightly horse-drawn wagons collect corpses left in the street. Sisters Helen and Lutie have moved to Denver from Ohio after their parents’ death. Helen, a nurse, and Lutie, a carefree advertising designer at Neusteter’s department store, share a small, neat house and each finds a local beau—for Helen a doctor, for Lutie a young student who soon enlists.

1852 Illinois. Eva Thompson has her future mapped out. Marriage to David Clarke and a family is all she wants. Her Pa has other ideas. He insists on taking the Oregon Trail to a better life and favors Harold Chapman as Eva's suitor. Marriage to Harold will provide Eva with everything she needs except . . . love.

Mourning the death of his father and gravely injured at the hands of the English, Jamie Fraser finds himself running with a band of mercenaries in the French countryside, where he reconnects with his old friend, Ian Murray. Both are nursing wounds, both have good reason to stay out of Scotland, and both are still virgins despite several opportunities to remedy that deplorable situation with ladies of easy virtue.