Somewhere out there exists an extinction level virus so powerful there is nothing that can stop it. In a misguided attempt to avert the future deadly threat, biologist Elias Marcum creates his own impervious virus. His arrogance in his work inadvertently causes the accidental release of the virus. By the time it is discovered, it is too late.

In the time it takes to create a single beat of a heart, 75 percent of the population drops dead. Within hours, another 20 percent succumb, leaving only a speck of human life remaining. Believing they are victims of a preliminary act of war and eventual invasion, a group of survivors trek across a barren United States following a radio signal. The simple plan was to band with others to fight and defend their homeland. However, their journey not only brings them together with other survivors but also brings them a chilling truth.

A mysterious growth covers three deer on Miller Run Road outside of Griffin, Arizona. The sickly animals are mistaken for scared until they brazenly attack a car, causing a fatal accident. Like everyone else in town, Cass “Scoop” McDaniels has lived in Griffin her entire life. When she is assigned the accident story, her findings are dismissed. The story dies with the people on the road. But Cass doesn’t give up.

Before the sun rose over the town of Sisterville, everything went black. A natural disaster of unknown origins takes the lives of every living creature and decimates the small town. Disgraced NASA scientist and now Cleveland weatherman Hero Galanis knows he is more than a local celebrity on television. He recognizes the anomaly on the satellite image as a repeat of the event that cost him his career. Decades earlier, Hero made predictions about the devastation the anomaly would cause, but those predictions pale in comparison to the reality the world currently faces.

It happens on a routine red-eye from Las Vegas to New York. Just as the plane breaks the early morning sky, in a blink of an eye, 144 passengers onboard flight 6520 die. There is no rhyme or reason. Experts scramble to find an explanation on how and why those on Flight 6520 met their demise so quickly and violently. It is hurriedly explained as a terror attack to the public, but General Buford Cane knows better. He has spent his entire career dedicated to the investigation and prevention of globe-threatening events.