After a mysterious global event known only as “The Change”, six strangers wake up in an underground research facility where they learn that they’re part of the Extinction Trials - a scientific experiment to restart the human race. But the Extinction Trials harbors a very big secret. And so does the world outside.

Dr. Sam Anderson is one of the most celebrated scientists in history. Ten years ago, he invented a device that changed the world forever. Now his life is about to be ripped apart—and his own creation may be to blame. One fateful morning, Sam discovers that his girlfriend has been murdered and that his daughter is accused of the crime. Sam believes she's innocent, but he can't prove it. There's only one thing he can do to save his daughter: confess to the crime. And so he does. But in the future, murderers aren't sent to prison. They're sent to the past.

In Atlanta, Dr. Peyton Shaw is awakened by the phone call she has dreaded for years. As the CDC's leading epidemiologist, she's among the first responders to outbreaks around the world. It's a lonely and dangerous job, but it's her life - and she's good at it. This time she may have met her match. In Kenya, an Ebola-like pathogen has infected two Americans. One lies at death's door. With the clock ticking, Peyton assembles her team and joins personnel from the Kenyan Ministry of Health and the WHO.

The ice is coming. It was the last thing we expected, but the world is freezing. A new ice age has dawned. Billions have fled the glaciers. A cataclysmic war is coming. In orbit, a group of scientists are running the Winter Experiments, a last-ditch attempt to understand why the planet is cooling. None of the climate models they build make sense. But then they discover an anomaly, an unexplained variation in solar radiation...and something else. Close to the burning edge of the sun, they catch a fleeting glimpse of something that shouldn’t be there....

Dr. Tyson Klein is a quantum physicist who has dedicated his entire life to his research. At CERN, he analyses data generated by the Large Hadron Collider, the world's biggest and most powerful particle accelerator. Now, Ty believes he's found a pattern in its output. It looks like an organised data stream, being broadcast over what he calls a quantum radio. Could it be a signal from another universe? A message sent from the future? Or something else entirely?