As Britain stands alone against a monstrous enemy, the inhabitants of Pearl Street face hardship and heartbreak with courage and humour. The war touches each of them in a different way: for Annie Poulson, a widow, it means never-ending worry when her twin boys are called up and sent to France; Sheila Reilly's husband, Cal, faces the terror of U-Boat attacks; Eileen Costello is liberated from a bitter, loveless marriage when her husband is sent to Egypt.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

In 1918, after four harrowing years on the Western Front, Tom Sherbourne returns to Australia to take a job as the lighthouse keeper on remote Janus Rock. To this isolated island, where the supply boat comes only four times a year and shore leaves are granted every other year at best, Tom brings a young, bold, and loving wife, Isabel. Three years later, after two miscarriages and one stillbirth, the grieving Isabel is tending the grave of her newly lost infant when she hears a baby’s cries on the wind. A boat has washed up on shore carrying a dead man and a living baby.

Born on a farm outside Edinburgh in the mid-19th century, Agnes Watt is embraced by family, community, and tradition. Her youthful hopes and dreams are quashed but she falls in love and marries William Miller, a Gordon Highlander. Life spirals into dark places as the couple become ensnared in the nightmare that descended on the Scottish working class during the industrial revolution. The triumphs of the great Victorian era came at an appalling human cost and Agnes fights against disease and grinding poverty.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

In the summer of 1916, Private Daniel Baker marches into battle with the boys of Nova Scotia's 25th Battalion. Out of brutal necessity, Danny has steeled himself against the trials and horrors of war, but he is completely unprepared to meet the love of his life in war-torn France. Audrey Poulin has the soul of an artist. She lives alone with her grandmother in the quiet French countryside, where her only joy is in her brush and palette. When by chance she encounters Danny, the handsome young soldier captures her heart and inspires her painting.

In the '60s, Athene Forster was the most glamorous girl of her generation. Nicknamed the Last Deb, she was also beautiful, spoiled, and out of control. When she agreed to marry the gorgeous young heir Douglas Fairley-Hulme, her parents breathed a sigh of relief. But within two years, rumors had begun to circulate about Athene's affair with a young salesman.

In 1920s Glasgow, Beattie Blaxland falls pregnant to her married lover Henry just before her nineteenth birthday. Abandoned by her family, Beattie and Henry set sail for a new life in Australia. In 2009, London, prima ballerina Lydia Blaxland-Hunter is also discovering that life can also have its ups and downs. Unable to dance again after a fall, Lydia returns home to Australia to recuperate.

London, 1940. Bombs fall and Josie Banks’ world crumbles around her. Her overbearing husband, Stan, is unreachable, called to service. Her home, a ruin of rubble and ash. Josie’s beloved tearoom boss has been killed, and Josie herself is injured, with nothing left and nowhere to go. Evacuated to the English countryside, Josie ends up at the estate of the aristocratic Miss Harcourt, a reluctant host to the survivors of the Blitz. Now a threat looms larger than anyone imagined. And a dangerous secret is about to upend Josie’s life again.

Olivia Shields is back in Carlisle Bay, Connecticut, after having traveled the world as a professional ballet dancer. Dancing was her life. Chasing performance dreams is all she's ever known or planned for. One summer she spent in Carlisle Bay before heading to Juilliard left her both heartbroken and more focused on her career than ever. A back injury has forced some changes. She'll take on a new role as the manager of her aunt's coastal boutique. After all, she's completely over the boy who broke her heart forever ago.

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

East London, 1888 - a city apart. A place of shadow and light where thieves, whores, and dreamers mingle, where children play in the cobbled streets by day and a killer stalks at night, where bright hopes meet the darkest truths. Here, by the whispering waters of the Thames, Fiona Finnegan, a worker in a tea factory, hopes to own a shop one day, together with her lifelong love, Joe Bristow, a costermonger's son. With nothing but their faith in each other to spur them on, Fiona and Joe struggle, save, and sacrifice to achieve their dreams.

Some women are destined to arouse in men either fierce hatred or insatiable desire. Such a woman was Katie Mulholland. At 15, a scullery maid in the house of the Rosires, she had been raped by the master. Now, many years later, she had enough money to maintain three carriages if she wanted to and she was on her way to see Bernard Rosier under very different circumstances.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Lavender Road boasts a pawnbroker, a pub, two rows of terraced working class homes, and, at one end, the big house owned by the local brewer. When war breaks out, the lives and fortunes of the families who live in Lavender Road are changed out of all recognition.