Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.

For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.

Pharmaceutical breakthroughs such as antibiotics and vaccines rank among some of the greatest advancements in human history. Yet, exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry.

Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year. But now GM is rapidly being supplanted by a new system called CRISPR or "gene editing". Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.

Beneath the gloss of star chefs and crystal-laden tables, the truffle supply chain is touched by theft, secrecy, sabotage, and fraud. Farmers patrol their fields with rifles and fear losing trade secrets to spies. Hunters plant poisoned meatballs to eliminate rival truffle-hunting dogs. Naive buyers and even experts are duped by liars and counterfeits. Deeply reported and elegantly written, this exposé documents the dark, sometimes deadly crimes at each level of the truffle’s path from ground to plate, making sense of an industry that traffics in scarcity, seduction, and cash.

While serving with the Peace Corps in Swaziland, Thomas Cowan encountered the work of Rudolf Steiner and Weston A. Price - two men whose ideas would fascinate and challenge him for decades to come. Both drawn to the art of healing and repelled by the way medicine was - and continues to be - practiced in the United States, Cowan returned from Swaziland, went to medical school, and established a practice.

The New York Times best-selling author traces the development of technology from the Industrial Age to the Digital Age to explore the single component crucial to advancement - precision - in a superb history that is both an homage and a warning for our future.

The prize-winning and best-selling author of Say Nothing presents a grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

A breakout best seller in Italy, now available for American listeners for the first time, Genesis: The Story of How Everything Began is a short, humanistic tour of the origins of the universe, earth, and life - drawing on the latest discoveries in physics to explain the seven most significant moments in the creation of the cosmos.

In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the next Steve Jobs: a brilliant Stanford dropout whose startup “unicorn” promised to revolutionize the medical industry with its breakthrough device, which performed the whole range of laboratory tests from a single drop of blood. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.5 billion.

From the New York Times best-selling author of Dreamland, a searing follow-up that explores the terrifying next stages of the opioid epidemic and the quiet yet ardent stories of community repair.

Are art and science separated by an unbridgeable divide? Can they find common ground? In this book, neuroscientist Eric R. Kandel, whose remarkable scientific career and deep interest in art give him a unique perspective, demonstrates how science can inform the way we experience a work of art and seek to understand its meaning. Kandel illustrates how reductionism - the distillation of larger scientific or aesthetic concepts into smaller, more tractable components - has been used by scientists and artists alike to pursue their respective truths.

A panoramic investigation of the subterranean landscape, from sacred caves and derelict subway stations to nuclear bunkers and ancient underground cities - an exploration of the history, science, architecture, and mythology of the worlds beneath our feet.

The Real Anthony Fauci details how Fauci, Gates, and their cohorts use their control of media outlets, scientific journals, key government and quasi-governmental agencies, global intelligence agencies, and influential scientists and physicians to flood the public with fearful propaganda about COVID-19 virulence and pathogenesis, and to muzzle debate and ruthlessly censor dissent.

"Ants are the most warlike of all animals, with colony pitted against colony.... Their clashes dwarf Waterloo and Gettysburg", writes Edward O. Wilson in his most finely observed work in decades. In a myrmecological tour to such far-flung destinations as Mozambique and New Guinea, the Gulf of Mexico's Dauphin Island and even his parents' overgrown yard back in Alabama, Wilson thrillingly evokes his nine-decade-long scientific obsession with more than 15,000 ant species.

Traveling across millennia, weaving the experiences and world views of cultures both extinct and extant, The Invention of Yesterday shows that the engine of history is not so much heroic (battles won), geographic (farmers thrive), or anthropogenic (humans change the planet) as it is narrative. Many thousands of years ago, when we existed only as countless small autonomous bands of hunter-gatherers widely distributed through the wilderness, we began inventing stories - to organize for survival, to find purpose and meaning, to explain the unfathomable.

Two pharmacists sit in a Boston courtroom accused of murder. The weapon: the fungus Exserohilum rostratum. The death count: 100 and rising. Kill Shot is the story of their hubris and fraud, discovered by a team of medical detectives who raced against the clock to hunt the killers and the fungal meningitis they'd unleashed.

A memoir of unblinking honesty and poignant, laugh-out-loud humor, Blackout is the story of a woman stumbling into a new kind of adventure - the sober life she never wanted. For Sarah Hepola, alcohol was "the gasoline of all adventure". She spent her evenings at cocktail parties and dark bars where she proudly stayed till last call. But there was a price. Publicly, she covered her shame with self-deprecating jokes, and her career flourished, but as the blackouts accumulated, she could no longer avoid a sinking truth.

Yes, you can become rich. No, it's not easy, but it's not as difficult as many people imagine - and it's definitely not impossible, as many cynics would have us believe.

If you’re like most people, the relentless daily grind of go-go-go, do-do-do, can run down your energy and deplete your resources. While most of us find our lives full of “Upstate” moments that rev up our stress engines, it doesn’t have to be this way. World-renowned sleep researcher Sara C. Mednick, PhD, shows us how we can access the most replenishing and repairing aspects of sleep through activities and moments that happen during our day by diving into our “Downstate”.

Now a number-one international best seller, Billion Dollar Whale is "an epic tale of white-collar crime on a global scale" (Publishers Weekly), revealing how a young social climber from Malaysia pulled off one of the biggest heists in history. In 2009, a chubby, mild-mannered graduate of the University of Pennsylvania's Wharton School of Business named Jho Low set in motion a fraud of unprecedented gall and magnitude—one that would come to symbolize the next great threat to the global financial system.

Pharmaceutical breakthroughs such as antibiotics and vaccines rank among some of the greatest advancements in human history. Yet, exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry.

Hardly anyone is happy with American health care these days. Patients are getting sicker and going bankrupt from medical bills. Doctors are burning out and making dangerous mistakes. Both parties blame our nation’s outdated and dysfunctional health care system. But that’s only part of the problem. In this important and timely book, Dr. Robert Pearl shines a light on the unseen and often toxic culture of medicine.

The author of the celebrated Victory tells the fascinating story of the intertwined lives of Sandra Day O'Connor and Ruth Bader Ginsburg, the first and second women to serve as Supreme Court justices.

From the masters of storytelling-meets-science, Patient Zero tells the long and fascinating history of disease outbreaks—how they start, how they spread, the science that lets us understand them, and how we race to destroy them before they destroy us. Written in the authors’ lively style, chapters include gripping medical stories about a particular disease or virus—smallpox, Bubonic plague, polio, HIV—that combine “Patient Zero” narratives, or the human stories behind outbreaks, with historical examinations of missteps, milestones, scientific theories, and more.

Aubrey Clayton traces the history of how statistics went astray, beginning with the groundbreaking work of the 17th-century mathematician Jacob Bernoulli and winding through gambling, astronomy, and genetics. Clayton recounts the feuds among rival schools of statistics, exploring the surprisingly human problems that gave rise to the discipline and the all-too-human shortcomings that derailed it.

At 26, apprentice baker Mia West has her entire life planned out: a Craftsman cottage in Seattle, a job baking at the Butter Emporium, and her first love - her boyfriend, Ethan - by her side. But when Ethan declares he “needs some space”, Mia’s carefully planned future crumbles. Feeling adrift, Mia joins her vivacious housemate Rosie on a humanitarian trip around the world funded by a reclusive billionaire.

The inspiring true story of a US Special Forces soldier who was medically retired after stepping on an IED and his incredible return to active duty. An engaging and harrowing account, Tip of the Spear tells the amazing story of one Green Beret's indomitable spirit.

Laurence Rees has spent 25 years meeting the survivors and perpetrators of the Third Reich and the Holocaust. In this sweeping history, he combines this testimony with the latest academic research to investigate how history's greatest crime was possible. Rees argues that while hatred of the Jews was at the epicenter of Nazi thinking, we cannot fully understand the Holocaust without considering Nazi plans to kill millions of non-Jews as well.

In The Formula: Unlocking the Secrets to Raising Highly Successful Children, Harvard economist Ronald Ferguson, named in a New York Times profile as the foremost expert on the US educational "achievement gap," along with award-winning journalist Tatsha Robertson, reveal an intriguing blueprint for helping children from all types of backgrounds become successful adults.