Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

The three sisters of Victory Walk in East London will face heartache and tears on the home front. As rationing, blackouts and bombs start to bite, life will change forever for the three sisters.

Liverpool, 1946: the blackout blinds may be coming down, but one family is about to face devastating misfortune. Dora Evans is finally marrying the love of her life, and her dreams of opening a dressmaking business look as if they might come true. With twin daughters on the way, Dora has everything she's ever wanted. But then tragedy strikes: one of Dora's babies dies in infancy, and a catastrophic fire changes their lives forever. Can Dora save herself, her marriage and her daughter?

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.

Lady Joanna Harcourt and her daughter, Sarah, discover their life of luxury at Goodwill House is over. Because with Lord Harcourt away fighting, the Harcourt girls are facing financial ruin. Lady Joanna is terrified of losing their home, but for Sarah, this means her dreams of becoming a doctor are over. Headstrong Sarah isn’t one to quit! War or not, she’s determined to find a way to save her home and follow her dreams - whatever it takes.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds.

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

Devon, 1918. When Jessie Hale loses her nursing job, she leaves London to become the nurse maid to the Kendle family. On arrival she finds the family in disarray. When their elderly Nanny suffers a bad fall, Jessie has to try to bring the household together. Gradually, Jessie finds her place in their lives. Jessie soon starts to love her life at Kendlebury Hall, but problems arise when her feelings for her employer start to change....

Dublin, 1952. When Mary Kate Ryan receives a surprise inheritance from the woman who abandoned her as a tiny baby, she’s stunned. All her life, she has longed to know why her mother disappeared, and now she’s devastated to realize that every lonely night she spent without a home or family of her own, her mother knew exactly where she was.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

London, 1940. Bombs fall and Josie Banks’ world crumbles around her. Her overbearing husband, Stan, is unreachable, called to service. Her home, a ruin of rubble and ash. Josie’s beloved tearoom boss has been killed, and Josie herself is injured, with nothing left and nowhere to go. Evacuated to the English countryside, Josie ends up at the estate of the aristocratic Miss Harcourt, a reluctant host to the survivors of the Blitz. Now a threat looms larger than anyone imagined. And a dangerous secret is about to upend Josie’s life again.

It’s 1942, and London remains under constant threat of enemy attack as the second world war rages on. In the Bethnal Green neighborhood, Nellie Morris counts every day lucky that she emerges from the underground shelters unharmed, her loving family still surrounding her. Three years into the war, she’s grateful to hold onto remnants of normalcy—her job as assisting the mayor and nights spent at the local pub with her best friend. But after a chance encounter with Ray, an American airman stationed nearby, Nellie becomes enchanted with the idea of a broader world.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.