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A Fatal Inheritance
How a Family Misfortune Revealed a Deadly Medical Mystery
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Narrated by:
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Roger Wayne
About this listen
Long-listed, BookPage Best Books of the Year, 2024
National Book Critics Circle Award nominee, 2024
Long-listed, Amazon.com Best Books of the Year, 2024
Long-listed, NPR Best Book of the Year, 2024
"Listeners will find A Fatal Inheritance to be an effective overview of research on cancer and hereditary predisposition, one that achieves serious investigation while remaining intensely human.”—BookPage
Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller
Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.
Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families.
In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.
A Macmillan Audio production from Henry Holt & Company.
©2024 Lawrence Ingrassia (P)2024 Macmillan AudioListeners also enjoyed...
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Critic reviews
“A Fatal Inheritance by Lawrence Ingrassia is a compelling personal chronicle of tragedy and triumph. It captures both the ineffable pain of families riddled with cancers and the remarkable research over the past half century by scientists determined to help them.”—Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer
"When two young doctors came across a family riddled with cancer for generations, they wondered why and began a decades long search for the answer. In A Fatal Inheritance, a riveting narrative of their quest, Lawrence Ingrassia intertwines a deeply personal and tearful story of unbearable family loss with an inspiring story of scientific discovery that revolutionized the understanding and treatment of cancer."—Walter Isaacson, author of Elon Musk, The Code Breaker and Steve Jobs
"When Lawrence Ingrassia lost his mother, sisters, brother and nephew to cancer, was it appallingly bad luck, or was there a common cause? This is the story of a family tragedy, a medical mystery, and the painstaking work of insightful scientists. By turns heartbreaking and hopeful, A Fatal Inheritance is a story of mortal loss and human resilience."—Geraldine Brooks, author of Horse and March
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- By Concerned_llama on 12-11-20
By: Phil Mason
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The Selfish Gene
- By: Richard Dawkins
- Narrated by: Richard Dawkins, Lalla Ward
- Length: 16 hrs and 12 mins
- Unabridged
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Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.
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Better than print!
- By J. D. May on 07-31-12
By: Richard Dawkins
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Welcome to the Universe
- An Astrophysical Tour
- By: Michael A. Strauss, J. Richard Gott, Neil deGrasse Tyson
- Narrated by: Michael Butler Murray
- Length: 17 hrs and 53 mins
- Unabridged
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Welcome to the Universe is a personal guided tour of the cosmos by three of today's leading astrophysicists. Inspired by the enormously popular introductory astronomy course that Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott taught together at Princeton, this book covers it all - from planets, stars, and galaxies to black holes, wormholes, and time travel.
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All About What We Know About the Universe - ALL
- By J.B. on 02-17-17
By: Michael A. Strauss, and others
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Letters from an Astrophysicist
- By: Neil deGrasse Tyson
- Narrated by: Neil deGrasse Tyson, Vikas Adam, Piper Goodeve, and others
- Length: 5 hrs and 35 mins
- Unabridged
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Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.
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Dear Neil...
- By Tina G. on 10-14-19
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Inspired
- How to Create Tech Products Customers Love, Second Edition
- By: Marty Cagan
- Narrated by: Marty Cagan
- Length: 7 hrs and 45 mins
- Unabridged
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How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.
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Great book, terrible audio wanted to ask a refund
- By Srikanth Ramanujam on 11-15-18
By: Marty Cagan
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Cosmic Queries
- StarTalk’s Guide to Who We Are, How We Got Here, and Where We’re Going
- By: James Trefil, Lindsey N. Walker - editor, Neil deGrasse Tyson
- Narrated by: Neil deGrasse Tyson, Lauren Fortgang
- Length: 6 hrs and 18 mins
- Unabridged
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In this illuminating audiobook, Tyson and coauthor James Trefil, a renowned physicist and science popularizer, take on the big questions that humanity has been posing for millennia - How did life begin? What is our place in the universe? Are we alone? - and provide answers based on the most current data, observations, and theories.
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Not worth it
- By Daniel Earl on 03-15-21
By: James Trefil, and others
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Your Brain Is a Time Machine
- The Neuroscience and Physics of Time
- By: Dean Buonomano
- Narrated by: Aaron Abano
- Length: 8 hrs and 51 mins
- Unabridged
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In Your Brain Is a Time Machine, brain researcher and best-selling author Dean Buonomano draws on evolutionary biology, physics, and philosophy to present his influential theory of how we tell and perceive time. The human brain, he argues, is a complex system that not only tells time but creates it; it constructs our sense of chronological flow and enables "mental time travel" - simulations of future and past events.
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Great book on an underrated subject
- By Neuron on 05-09-17
By: Dean Buonomano
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The Last Season
- By: Eric Blehm
- Narrated by: Jonathan Davis
- Length: 12 hrs and 34 mins
- Unabridged
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Destined to become a classic of adventure literature, The Last Season examines the extraordinary life of legendary backcountry ranger Randy Morgenson and his mysterious disappearance in California's unforgiving Sierra Nevada - mountains as perilous as they are beautiful. Eric Blehm's masterful work is a gripping detective story interwoven with the riveting biography of a complicated, original, and wholly fascinating man.
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Well Written Character Study of an NPS Ranger
- By Kathy in CA on 06-23-16
By: Eric Blehm
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what a story! But not a "story", which is often synonymous with "lie", in southern speak. This one is true.
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Cloistered takes the listener deep into the hidden world of a traditional Carmelite monastery as it approaches the third Millennium and tells the story of an intense personal journey into and out of an enclosed life of poverty, chastity, and obedience. Finding an apparently perfect world at Akenside Priory, in Northumberland, Catherine trusts herself to a group of twenty silent women, believing she is trusting herself to God. As the beauty and mystery of an ancient way of life enfold her, she surrenders herself wholly to its power, quite unaware of the complexity and dangers that lie ahead.
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Humans are complex, in life and death
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Dana Trent is only a preschooler the first time she uses a razor blade to cut up weed and fill dime bags for her schizophrenic father, King. While King struggles with his unmedicated psychosis, Dana’s mother, the Lady, a cold and self-absorbed woman whose personality disorders rule the home, guards large bricks of drugs from the safety of their squalid trailer. But when the Lady impulsively plucks Dana from the Midwest and moves the two of them south, their fresh start results in homelessness and bankruptcy.
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In this close-up look at the ardent love affair between the author and her painting teacher, which began in the 1970s, when she was seventeen and he was forty-seven and married with two children, Ciment not only reflects on how their love ignited (who leaned in first for that kiss?) but interrogates her 1990s memoir on the subject, Half a Life. She asks herself if she told the whole truth when she wrote about their passion back then, and what truth looked like to her in the even longer-ago era of love-bead curtains when she fell in love.
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Tracing a loose arc from Edwidge Danticat’s childhood to the COVID-19 pandemic and recent events in Haiti, the essays gathered in We’re Alone include personal narrative, reportage, and tributes to mentors and heroes such as Toni Morrison, Paule Marshall, Gabriel García Márquez, and James Baldwin that explore several abiding themes: environmental catastrophe, the traumas of colonialism, motherhood, and the complexities of resilience.
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Always a story to tell
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Grief Is for People is a deeply moving and surprisingly suspenseful portrait of friendship, and a book about loss packed with verve for life. Sloane Crosley is one of our most renowned observers of contemporary behavior, and now the pathos that has been ever present in her trademark wit is on full display. After the pain and confusion of losing her closest friend to suicide, Crosley looks for answers in friends, philosophy, and art, hoping for a framework more useful than the unavoidable stages of grief.
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Beautiful
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The Masters of Medicine
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Human history hinges on the battle to confront our most dangerous enemies—the half-dozen diseases responsible for killing almost all of mankind. The story of our medical triumphs reveals an inspiring tapestry of human achievement, but the journey was far from smooth. It is a tale replete with dramatic episodes as spellbinding as any blockbuster Hollywood movie. In The Masters of Medicine, Dr. Andrew Lam, an award-winning author and retinal surgeon, distills the long arc of medical progress down to the crucial moments that were responsible for the world's greatest medical miracles.
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Medical history comes to life
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Rosalind Brown's Practice shows us just one day. Annabel, sitting in her small student room, attempts to write an essay about Shakespeare. She follows a meticulous, solitary routine but finds it repeatedly thrown off course as the day progresses: by family and friends who demand her attention and time, by thoughts of her much older boyfriend and his impending visit, by wild sexual fantasies and stories of her own invented characters—and by darker crises, obliquely glimpsed but capable of derailing Annabel's carefully laid plans.
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Talented author; book won’t be for everyone
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The Swans of Harlem
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At the height of the Civil Rights movement, Lydia Abarca was a Black prima ballerina with a major international dance company—the Dance Theatre of Harlem, a troupe of women and men who became each other’s chosen family. She performed in some of ballet’s most iconic works with other trailblazing ballerinas, including the young women who became her closest friends—founding Dance Theatre of Harlem members Gayle McKinney-Griffith and Sheila Rohan, as well as first-generation dancers Karlya Shelton and Marcia Sells. The Swans of Harlem is a riveting account of these five accomplished women.
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An important story finally told
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My Girls
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In December 2016, the world was shaken by the sudden deaths of Carrie Fisher and her mother Debbie Reynolds, two unspeakable losses. The stunned public turned for solace to Debbie’s only remaining child, Todd Fisher. The son of "America’s Sweethearts" Debbie Reynolds and Eddie Fisher, Todd grew up amid the glamorous wealth and pretense of Hollywood. Thanks to his mother, Todd remained down to earth, his own man, but always close to his cherished mom, and to his sister through her meteoric rise to stardom and her struggle with demons that never diminished her humor, talent, or spirit.
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Detailed & heartfelt tribute
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Our Narrow Hiding Places
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Eighty-year-old Mieke Geborn’s life is one of quiet routine. Widowed for many years, she enjoys the view from her home on the New Jersey shore, visits with friends, and tai chi at the local retirement community. But when her beloved grandson, Will, and his wife, Teru, show up for a visit, things are soon upended. Their marriage is threatening to unravel, and Will has questions for his grandmother—questions about family secrets that have been lost for decades and are now finally rising to the surface.
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Imagination +History
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Sociopath
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Patric Gagne realized she made others uncomfortable before she started kindergarten. Something about her caused people to react in a way she didn’t understand. She suspected it was because she didn’t feel things the way other kids did. Emotions like fear, guilt, and empathy eluded her. For the most part, she felt nothing. And she didn’t like the way that “nothing” felt.
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Fascinating and Perfect Performance!
- By ScoobaRubio on 04-05-24
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Did I Ever Tell You?
- A Memoir
- By: Genevieve Kingston
- Narrated by: Genevieve Kingston
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Genevieve (Gwen) Kingston was just eleven years old when her mother passed away, leaving behind a chest filled with gifts and letters to celebrate the milestones of Gwen’s life and each of her birthdays until age thirty.
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Beautiful
- By Paloma M. Lee on 05-25-24
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Our Hidden Conversations
- What Americans Really Think About Race and Identity
- By: Michele Norris
- Narrated by: Michele Norris, full cast
- Length: 17 hrs and 44 mins
- Unabridged
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The prompt seemed simple: Race. Your Story. Six Words. Please Send. The answers, though, have been challenging and complicated. In the twelve years since award-winning journalist Michele Norris first posed that question, over half a million people have submitted their stories to The Race Card Project inbox. The stories are shocking in their depth and candor, spanning the full spectrum of race, ethnicity, identity, and class. Even at just six words, the micro-essays can pack quite a punch, revealing, fear, pain, triumph, and sometimes humor.
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Excellent in every way
- By Deb Evans on 02-21-24
By: Michele Norris
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American Daughter
- A Memoir
- By: Stephanie Thornton Plymale, Elissa Wald
- Narrated by: Mozhan Marno
- Length: 9 hrs and 5 mins
- Unabridged
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The sharp and surprising true story of a woman who finally sets out to understand her past, and the mother she had one day hoped to forget. Full of unexpected twists and unbelievable revelations, American Daughter is an immersive memoir that will have you on the edge of your seat to the very last minute.
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Amazing memoir
- By talltower4 on 09-02-21
By: Stephanie Thornton Plymale, and others
What listeners say about A Fatal Inheritance
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- Penelope
- 01-28-25
Fascinating medical nonfiction
Beautifully told story of families suffering from an inherited medical disorder and the researchers looking for the cause. The author uses the story of his own extended family and of several others to make this an unusually poignant and affecting book. The writing is outstanding and the narration is perfect.
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- Avid reader
- 05-17-24
Powerful story told incredibly well
Cancer decimated the author's family, taking lives way too soon, way too often, as he recounts in this book. But this story is much bigger than that. It's an incredibly powerful tale, not just of his family, but of other families, of posing questions and seeking answers. The lyrical prose of his retelling reads like a novel, while his decades as a journalist with the Wall Street Journal, the New York Times, and the Los Angeles Times come through in his detailed chronicling of the journey to unwrap the medical mystery of why his branch of the family (and so many other families) have been plagued by cancer. He skillfully distills medical research into everyday language so that readers can understand the science, while he pieces in families' stories so that they can empathize with the real-life toll cancer takes on so many.
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1 person found this helpful
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- Charlene
- 09-27-24
Absolutely beautifully written, fascinating, poignant, tragic and unforgettable.
I am an oncology nurse practitioner and the nerd in me adores a good biomedical documentary. This is more than that, it is an odyssey, and from the moment I started it, I could not put it down. The writing is also at a level that is understandable for people without backgrounds in science, nursing or medicine.
The history of the discovery of this particularly brutal heritable cancer syndrome is absolutely fascinating and Lawrence Engrassia skillfully weaves this together with stories from the initial families studied to ascertain the cause of the syndrome with stories of his own family. The details of these families repeated suffering as family member after family member is torn from them will forever be indelibly seared into my memory.
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- Lisa Ingrassia
- 06-07-24
Stunning story and great reporting
Beautifully reported book, wonderfully read by the narrator. The book intertwines the authors story of losing his entire family to cancer with the story of the epidemiologists who discovered a cancer gene, and the families they studied on their path. This book will be interesting to anyone who has lost a family member to cancer and grappled with fear and grief around that loss.
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- Patricia Elizondo
- 07-05-24
Touching story with powerful lessons in hope.
This book provides an overview of the history of cancer diagnosis and treatments in a thoughtful way that is accessible to the non-scientific community. It sets the story context in the lives of cancer patients and their families. If you have a loved one who experienced cancer, you will cry painful tears and hopeful ones. I had to take breaks from the book, and each time it was easy to pick it back up. 🫶
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- Mildred
- 01-08-25
The research
The personal facts of these families was so honest. The cancer research into the causes of cancer was very talented.
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- patricia Caballero Rodriguez
- 01-15-25
Full of emotion
Honest and straightforward prose , full of emotion. I felt the story and learned so much as well . Worth enduring the technical parts , overall enjoyed .
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- Katherine
- 05-20-24
An important book
This book blends the heart wrenching story of the Ingrassia family and how cancer shadowed three generations with chronicling the discovery of a genetic link. Superb story telling that keeps the reader engaged even as we can anticipate the devastating outcome. The science is conveyed clearly, so that non-scientists can grasp the progress to discovering the key mutation. Engrossing, illuminating and personal.
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- Linda Thompson
- 06-02-24
An Elucidating Memoir
Mr. Ingrassia has managed to write a reader friendly treatise on cancer research that reads like a novel. With a journalist’s talent for getting to the heart of a story in a clear and concise manner, he educates the reader on the process of medical research all the while interspersing the technical issues with the very touching human stories of families, including his own, plagued by recurring cancers. This memoir is truly a masterpiece of research by the author as well as a love letter to his family.
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- mmk
- 06-05-24
Fascinating history, heartbreaking story
I am affected by an inherited genetic mutation with increased cancer risk, and an advocate for expanded germline genetic testing for more people, I feel like I am pretty knowledgeable about the topic but I did not know the backstory and history of the way researchers worked to discover and demonstrate the cancer-genetic link. It was very interesting and told in a way that was technical yet understandable - and interesting! The author wove this background history into the devastating losses in his own family that came, one after another, just a bit too early in time for the discoveries of the genetic link to be beneficial for them. I listened to this audiobook twice to absorb it all. I rarely leave reviews, but this one touched me. I hope it is read widely and that even one family will take a closer look at their family experience with cancer and inquire about germline testing - it could save the lives of the current and next generations.
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