
A Fatal Inheritance
How a Family Misfortune Revealed a Deadly Medical Mystery
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Narrado por:
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Roger Wayne
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Long-listed, BookPage Best Books of the Year, 2024
National Book Critics Circle Award nominee, 2024
Long-listed, Amazon.com Best Books of the Year, 2024
Long-listed, NPR Best Book of the Year, 2024
"Listeners will find A Fatal Inheritance to be an effective overview of research on cancer and hereditary predisposition, one that achieves serious investigation while remaining intensely human.”—BookPage
Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller
Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.
Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families.
In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.
A Macmillan Audio production from Henry Holt & Company.
©2024 Lawrence Ingrassia (P)2024 Macmillan AudioLos oyentes también disfrutaron...
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Reseñas de la Crítica
“A Fatal Inheritance by Lawrence Ingrassia is a compelling personal chronicle of tragedy and triumph. It captures both the ineffable pain of families riddled with cancers and the remarkable research over the past half century by scientists determined to help them.”—Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer
"When two young doctors came across a family riddled with cancer for generations, they wondered why and began a decades long search for the answer. In A Fatal Inheritance, a riveting narrative of their quest, Lawrence Ingrassia intertwines a deeply personal and tearful story of unbearable family loss with an inspiring story of scientific discovery that revolutionized the understanding and treatment of cancer."—Walter Isaacson, author of Elon Musk, The Code Breaker and Steve Jobs
"When Lawrence Ingrassia lost his mother, sisters, brother and nephew to cancer, was it appallingly bad luck, or was there a common cause? This is the story of a family tragedy, a medical mystery, and the painstaking work of insightful scientists. By turns heartbreaking and hopeful, A Fatal Inheritance is a story of mortal loss and human resilience."—Geraldine Brooks, author of Horse and March
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I Am Bunny
- How a ""Talking"" Dog Taught Me Everything I Need to Know About Being Human
- De: Alexis Devine
- Narrado por: Alexis Devine
- Duración: 6 h y 35 m
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When Bunny, a fluffy, black-and-white sheepadoodle, was eight weeks old, her guardian Alexis presented her with an odd gift: a button programed to say “outside” when pressed. Within a few weeks, Bunny was using it all the time and Alexis, encouraged by Bunny’s progress, continued to introduce more buttons and more words . . . Three years later, Bunny can now communicate using over one hundred buttons, stringing together important, relatable, philosophical phrases such as “Love you Mom,” “Dad went poop,” and “Ugh why?”
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Ya gotta love animals
- De Vicky Snow en 10-31-24
De: Alexis Devine
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Beneath the Surface
- Killer Whales, SeaWorld, and the Truth Beyond Blackfish
- De: John Hargrove, Howard Chua-Eoan
- Narrado por: John Hargrove
- Duración: 8 h y 21 m
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Over the course of two decades, John Hargrove worked with 20 different whales on two continents and at two of SeaWorld's U.S. facilities. For Hargrove, becoming an orca trainer fulfilled a childhood dream. However, as his experience with the whales deepened, Hargrove came to doubt that their needs could ever be met in captivity.
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Tragic, Brutal
- De Gillian en 04-16-15
De: John Hargrove, y otros
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The Treeline
- The Last Forest and the Future of Life on Earth
- De: Ben Rawlence
- Narrado por: Jamie Parker
- Duración: 11 h y 59 m
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For the last 50 years, the trees of the boreal forest have been moving north. The Treeline takes us along this critical frontier of our warming planet from Norway to Siberia, Alaska to Greenland, to meet the scientists, residents, and trees confronting huge geological changes.
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A surprising find
- De BearheartRaven en 02-23-22
De: Ben Rawlence
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The King's Assassin
- The Secret Plot to Murder King James I
- De: Benjamin Woolley
- Narrado por: David Timson
- Duración: 12 h y 17 m
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An absorbing account of the conspiracy to kill King James I by his handsome lover, the duke of Buckingham, a historical crime that has remained hidden for 400 years....
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Wonderful read!
- De LaDonna en 10-26-24
De: Benjamin Woolley
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God Save Benedict Arnold
- The True Story of America's Most Hated Man
- De: Jack Kelly
- Narrado por: Jim Seybert
- Duración: 8 h y 38 m
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Benedict Arnold committed treason—for more than two centuries, that's all that most Americans have known about him. Yet Arnold was much more than a turncoat—his achievements during the early years of the Revolutionary War defined him as the most successful soldier of the era. God Save Benedict Arnold tells the gripping story of Arnold's rush of audacious feats—his capture of Fort Ticonderoga, his Maine mountain expedition to attack Quebec, the famous artillery brawl at Valcour Island, the turning-point battle at Saratoga—that laid the groundwork for our independence.
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Missing the Whole Story
- De Derek L. en 08-14-24
De: Jack Kelly
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Riding Home
- The Power of Horses to Heal
- De: Tim Hayes
- Narrado por: David Stifel
- Duración: 8 h y 23 m
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Riding Home:The Power of Horses to Heal, is the first and only audiobook to scientifically and experientially explain why horses have the extraordinary ability to emotionally transform the lives of thousands of men, women and children, whether they are horse lovers, or suffering from deep psychological wounds. It is an audiobook for anyone who wants to experience the joy, wonder, self-awareness and peace of mind that comes from creating a horse/human relationship, and it puts forth and clarifies the principles of today's Natural Horsemanship....
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So disappointed
- De Crystal Matthews en 03-24-22
De: Tim Hayes
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Lucid Dying
- The New Science Revolutionizing How We Understand Life and Death
- De: Sam Parnia MD PhD
- Narrado por: Brian Nishii
- Duración: 11 h y 39 m
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Today, for the first time in history, the scientific exploration of death and what happens when we die is real, active and ongoing. Contrary to popular perceptions, this subject is no longer the remit of philosophy, religion, or personal opinion. Truly remarkable scientific discoveries that will fundamentally affect everyone’s lives now and in the future are taking place, yet very few people are aware of them. Most people—including scientists and doctors—maintain strong beliefs about death and its experience. Those beliefs are rooted in traditional, and often cultural, notions of death.
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Excited to See Scientific Rigor Applied to This Vital Topic
- De Mav en 08-27-24
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Nazi Wives
- The Women at the Top of Hitler's Germany
- De: James Wyllie
- Narrado por: Dalya Raphael
- Duración: 9 h y 30 m
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Goering, Goebbels, Himmler, Heydrich, Hess, Bormann - names synonymous with power and influence in the Third Reich. Perhaps less familiar are Carin, Emmy, Magda, Margarete, Lina, Ilse, and Gerda. These are the women behind the infamous men - complex individuals with distinctive personalities who were captivated by Hitler and whose everyday lives were governed by Nazi ideology. Throughout the rise and fall of Nazism these women loved and lost, raised families, and quarreled with their husbands and each other, all the while jostling for position with the Fuhrer himself.
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Scary
- De Three River en 05-15-21
De: James Wyllie
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The Cure for Women
- Dr. Mary Putnam Jacobi and the Challenge to Victorian Medicine That Changed Women's Lives Forever
- De: Lydia Reeder
- Narrado por: Sara Sheckells
- Duración: 14 h y 9 m
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Full of larger than life characters and cinematically written, The Cure for Women documents the birth of a sexist science still haunting us today as the fight for control of women’s bodies and lives continues.
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Well organized sadly relevant today
- De UnreliableHeart en 03-18-25
De: Lydia Reeder
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Descent into Darkness
- Pearl Harbor, 1941, A Navy Diver's Memoir
- De: Edward C. Raymer
- Narrado por: Peter Johnson
- Duración: 7 h y 24 m
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On December 7, 1941, as the great battleships Arizona, Oklahoma, and Utah lie paralyzed and burning in the aftermath of the Japanese attack on Pearl Harbor. A crack team of U.S. Navy salvage divers headed by Edward C. Raymer are hurriedly flown to Oahu from the mainland. Their two-part orders are direct and straightforward: (1) rescue as many trapped sailors and Marines as possible, and (2) resurrect what remains of America's once mighty pacific fleet. Descent Into Darkness tells their story.
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A Massive Disappointment
- De Matthew en 10-14-15
De: Edward C. Raymer
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Around the World in Eighty Games
- From Tarot to Tic-Tac-Toe, Catan to Chutes and Ladders, a Mathematician Unlocks the Secrets of the World's Greatest Games
- De: Marcus du Sautoy
- Narrado por: Mark Elstob
- Duración: 12 h y 36 m
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Spanning millennia, oceans and continents, countries and cultures, Around the World in Eighty Games gleefully explores how mathematics and games have always been deeply intertwined. Renowned mathematician Marcus du Sautoy investigates how games provided the first opportunities for deep mathematical insight into the world, how understanding math can help us play games better, and how both math and games are integral to human psychology and culture.
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Overall, a very entertaining read.
- De Matt en 11-13-23
De: Marcus du Sautoy
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Interpretation of Cats
- Understanding the Psychology of Our Feline Companions
- De: Claude Béata
- Narrado por: David Watson, Neil Gardner
- Duración: 7 h y 27 m
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Cats are mysterious creatures, and the relationship between humans and cats has never been simple. Curious and affectionate, independent and uninterested, predator and prey. Their true nature continues to elude us, and their subtle and complex behavioral problems can often seem unsolvable or incomprehensible. So, how can we tell if a cat is suffering? What are the root causes of feline aggression? And how can we treat patients who can’t speak for themselves?
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Wonderful insight
- De Tom C en 01-31-25
De: Claude Béata
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The Burning Shore
- How Hitler's U-Boats Brought World War II to America
- De: Ed Offley
- Narrado por: Robertson Dean
- Duración: 7 h y 18 m
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On June 15, 1942, as thousands of vacationers lounged in the sun on Virginia Beach, a massive fireball erupted from a convoy of oil tankers steaming into Chesapeake Bay. By the next day, three ships lay at the bottom of the channel, victims of Lieutenant-Commander Horst Degen and his crew on the German submarine U-701. In The Burning Shore, acclaimed military reporter Ed Offley presents a thrilling account of Degen's rampage along the American coast and of US Lieutenant Harry J. Kane's quest to bring him down.
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Ugh, Perhaps a Second Listen is Required?
- De Matthew en 09-05-15
De: Ed Offley
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At Any Cost
- A Father's Betrayal, a Wife's Murder, and a Ten-Year War for Justice
- De: Rebecca Rosenberg, Selim Algar
- Narrado por: Gabra Zackman
- Duración: 8 h y 45 m
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Wealthy, beautiful, and brilliant, Shele Danishefsky had fulfillment at her fingertips. Having conquered Wall Street, she was eager to build a family with her much younger husband, promising Ivy League graduate Rod Covlin. But when his hidden vices surfaced, marital harmony gave way to a merciless divorce. Rod had long depended on Shele's income to fund his tastes for high stakes backgammon and infidelity - and she finally vowed to sever him from her will. In late December 2009, Shele made an appointment with her lawyer. She would never make it to that meeting.
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Tightly-written true crime; excellent narration.
- De Janean Laidlaw en 06-27-21
De: Rebecca Rosenberg, y otros
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Index, a History of The
- A Bookish Adventure from Medieval Manuscripts to the Digital Age
- De: Dennis Duncan
- Narrado por: Neil Gardner
- Duración: 8 h y 9 m
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Most of us give little thought to the back of the book - it's just where you go to look things up. But as Dennis Duncan reveals in this delightful and witty history, hiding in plain sight is an unlikely realm of ambition and obsession, sparring and politicking, pleasure and play. In the pages of the index, we might find "Butchers, to be avoided", or "Cows that shite Fire", or even catch "Calvin in his chamber with a Nonne". Here, for the first time, is the secret world of the index: an unsung but extraordinary everyday tool, with an illustrious but little-known past.
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Maybe a book that should be read rather than listened to
- De Amazon Customer en 11-09-22
De: Dennis Duncan
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Through the Valley
- My Captivity in Vietnam
- De: William Reeder Jr.
- Narrado por: Corey M. Snow
- Duración: 8 h y 11 m
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In 1971 William Reeder was a senior captain on his second tour in Vietnam. He had flown armed, fixed-wing OV-1 Mohawks on secret missions deep into enemy territory in Laos, Cambodia, and North Vietnam, on his first tour. He returned as a helicopter pilot eager to experience a whole new perspective as a Cobra gunship pilot. Believing that Nixon's Vietnamization would soon end the war, Reeder was anxious to see combat action. To him, it appeared that the Americans had prevailed, beaten the Viet Cong, and were passing everything over to the South Vietnamese Army so Americans could leave.
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Best narration.
- De Speed77 en 01-05-25
Lo que los oyentes dicen sobre A Fatal Inheritance
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- Avid reader
- 05-17-24
Powerful story told incredibly well
Cancer decimated the author's family, taking lives way too soon, way too often, as he recounts in this book. But this story is much bigger than that. It's an incredibly powerful tale, not just of his family, but of other families, of posing questions and seeking answers. The lyrical prose of his retelling reads like a novel, while his decades as a journalist with the Wall Street Journal, the New York Times, and the Los Angeles Times come through in his detailed chronicling of the journey to unwrap the medical mystery of why his branch of the family (and so many other families) have been plagued by cancer. He skillfully distills medical research into everyday language so that readers can understand the science, while he pieces in families' stories so that they can empathize with the real-life toll cancer takes on so many.
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- Penelope
- 01-28-25
Fascinating medical nonfiction
Beautifully told story of families suffering from an inherited medical disorder and the researchers looking for the cause. The author uses the story of his own extended family and of several others to make this an unusually poignant and affecting book. The writing is outstanding and the narration is perfect.
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- Patricia Elizondo
- 07-05-24
Touching story with powerful lessons in hope.
This book provides an overview of the history of cancer diagnosis and treatments in a thoughtful way that is accessible to the non-scientific community. It sets the story context in the lives of cancer patients and their families. If you have a loved one who experienced cancer, you will cry painful tears and hopeful ones. I had to take breaks from the book, and each time it was easy to pick it back up. 🫶
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- Charlene
- 09-27-24
Absolutely beautifully written, fascinating, poignant, tragic and unforgettable.
I am an oncology nurse practitioner and the nerd in me adores a good biomedical documentary. This is more than that, it is an odyssey, and from the moment I started it, I could not put it down. The writing is also at a level that is understandable for people without backgrounds in science, nursing or medicine.
The history of the discovery of this particularly brutal heritable cancer syndrome is absolutely fascinating and Lawrence Engrassia skillfully weaves this together with stories from the initial families studied to ascertain the cause of the syndrome with stories of his own family. The details of these families repeated suffering as family member after family member is torn from them will forever be indelibly seared into my memory.
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- Mildred
- 01-08-25
The research
The personal facts of these families was so honest. The cancer research into the causes of cancer was very talented.
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- patricia Caballero Rodriguez
- 01-15-25
Full of emotion
Honest and straightforward prose , full of emotion. I felt the story and learned so much as well . Worth enduring the technical parts , overall enjoyed .
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- Katherine
- 05-20-24
An important book
This book blends the heart wrenching story of the Ingrassia family and how cancer shadowed three generations with chronicling the discovery of a genetic link. Superb story telling that keeps the reader engaged even as we can anticipate the devastating outcome. The science is conveyed clearly, so that non-scientists can grasp the progress to discovering the key mutation. Engrossing, illuminating and personal.
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- Linda Thompson
- 06-02-24
An Elucidating Memoir
Mr. Ingrassia has managed to write a reader friendly treatise on cancer research that reads like a novel. With a journalist’s talent for getting to the heart of a story in a clear and concise manner, he educates the reader on the process of medical research all the while interspersing the technical issues with the very touching human stories of families, including his own, plagued by recurring cancers. This memoir is truly a masterpiece of research by the author as well as a love letter to his family.
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- Lisa Ingrassia
- 06-07-24
Stunning story and great reporting
Beautifully reported book, wonderfully read by the narrator. The book intertwines the authors story of losing his entire family to cancer with the story of the epidemiologists who discovered a cancer gene, and the families they studied on their path. This book will be interesting to anyone who has lost a family member to cancer and grappled with fear and grief around that loss.
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- Margaret
- 03-23-25
Very Interesting and Informative
I found this audio book fascinating and easy to listen to. I highly recommend this book and author.
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