Stacia Altman has just received some terrible news. She was just diagnosed with a terminal disease. Worse yet, she's not sure if her death will matter to anyone-including herself. Once an adventurous young girl with a passion for art history, she has somehow evolved into a sarcastic and listless 38-year-old wife of an ultra-controlling husband…. Instead of lying down on the tracks and waiting for a train to run her over, Stacia decides to abandon the societal role she has played, in order to piece together whatever shreds of her life she can, before it's too late.

Anastasia (Stacia) Uqualla has been dead for 11 years when she suddenly awakens in the body of the renowned Renaissance beauty, Simonetta Vespucci. She reunites with Mariano, the father of Botticelli, whose ghostly presence has kept her company in the afterlife. Her journey through the Renaissance will also find her rubbing elbows with the young Leonardo da Vinci, Lorenzo de' Medici, and many other Renaissance painters, including Botticelli himself.