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The For Kidneys Sake podcast series is brought to you by Imperial College Healthcare NHS Trust and North West London Integrated Care Board (NWL NHS).

In this episode, consultants Prof Jeremy Levy and Dr Andrew Frankel, both nephrologists at Imperial College Healthcare NHS Trust, discuss the significance and management of microscopic (non-visible) haematuria in primary care. They provide practical guidance for general practitioners on how to interpret urine dipstick findings, the appropriate steps for investigation, and when specialist referral is warranted. The conversation emphasises the importance of not overlooking persistent haematuria, while also acknowledging the challenges in balancing appropriate concern with unnecessary anxiety or over-referral.

The clinicians explore differential diagnoses, such as glomerulonephritis, IgA nephropathy, and hereditary conditions like thin basement membrane disorder or Alport syndrome. They stress the role of imaging, the presence of proteinuria, and age-based referral pathways in forming a management plan. A key theme is the long-term follow-up of patients with isolated haematuria, even when kidney function is normal, to monitor for progression via regular kidney health checks in primary care. The discussion is informative and grounded in real-world experience, aiming to clarify an area that is often perceived as ambiguous in general practice.

Three Main Takeaways:

1. Persistent microscopic haematuria warrants investigation and should not be dismissed, particularly when confirmed on repeat testing and associated with other findings such as proteinuria.
2. All patients with confirmed haematuria should undergo a renal ultrasound, and referral decisions should be guided by age and associated symptoms or findings. Generally, referrals are made to urology if the patient is over 50, and to nephrology if the patient is under 50 or if proteinuria is present.
3. Even when no serious underlying condition is identified, patients with isolated haematuria require annual monitoring, including blood pressure, kidney function (GFR), and urine albumin-to-creatinine ratio, ideally recorded in primary care records to ensure lifelong follow-up.

Resource Links:
NICE GUIDELINES [NG203] chronic kidney disease: assessment and management Overview | Chronic kidney disease: assessment and management | Guidance | NICE

Northwest London CKD guidelines for primary care Chronic kidney disease (nwlondonicb.nhs.uk)

The purpose of this podcast is to inform and educate health care professionals working in the primary care and community setting. The content is evidence based and consistent with NICE guidelines and North West Guidelines available at the time of publication.

The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement.

Produced by award-winning media and marketing specialist Heather Pownall of Heather's Media Hub

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The For Kidneys Sake podcast series is brought to you by Imperial College Healthcare NHS Trust and North West London Integrated Care Board (NWL NHS).

In this episode of For Kidneys Sake, consultants Prof Jeremy Levy and Dr Andrew Frankel are joined by Dr Melanie Dani, a geriatrician, to discuss the complexities of managing chronic kidney disease (CKD) in older adults. They highlight the importance of distinguishing between chronological age and frailty, two overlapping but distinct concepts that significantly influence clinical decision-making. The conversation explores how kidney function naturally declines with age, and raises the critical question of when this becomes a pathological concern requiring medical intervention.

Dr Dani stresses the value of personalised care, reminding listeners that older adults are not a homogenous group. Whether someone is a fit 85-year-old playing tennis or a frail resident in a care home, their values, priorities and tolerance for medical treatment will differ. The episode encourages shared decision-making, consideration of overall health context, and careful use of medications like ACE inhibitors and SGLT2 inhibitors based on likely benefits and side effects, rather than age alone.

Three Key Takeaways

1. Ageing vs Frailty: Frailty is a better predictor of health outcomes than age alone. It’s essential to assess a patient’s overall vulnerability and resilience when managing CKD.
2. Reduced GFR in Older Adults: A declining GFR may reflect normal ageing rather than disease, but it still carries risks, particularly cardiovascular. Management should be tailored to the individual, not solely guided by guidelines.
3. Personalised, Contextualised Care: Decisions about referral, investigation and treatment must consider the whole person—their wishes, comorbidities, and quality of life—rather than focusing only on kidney function metrics.

Resource Links:
NICE GUIDELINES [NG203] chronic kidney disease: assessment and management Overview | Chronic kidney disease: assessment and management | Guidance | NICE

Northwest London CKD guidelines for primary care Chronic kidney disease (nwlondonicb.nhs.uk)

The purpose of this podcast is to inform and educate health care professionals working in the primary care and community setting. The content is evidence based and consistent with NICE guidelines and North West Guidelines available at the time of publication.

The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement.

Produced by award-winning media and marketing specialist Heather Pownall of Heather's Media Hub

Send us a text

The For Kidneys Sake podcast series is brought to you by Imperial College Healthcare NHS Trust and North West London Integrated Care Board (NWL NHS).

Welcome to For Kidneys’ Sake! The new name for our podcast series is previously known as The Rest Is Kidneys. In this first episode of our new 20-part series, Prof Jeremy Levy and Dr Andrew Frankel return to tackle a topic that crops up frequently in both clinic and primary care: supplements, herbal remedies, and recreational drugs and what they really mean for people with chronic kidney disease (CKD).

This episode explores everything from high-dose vitamins and gym-related creatine use to the dangers of anabolic steroids, ketamine, and certain traditional herbal medicines. With their usual clarity and clinical insight, Jeremy and Andrew offer practical advice for clinicians and thoughtful guidance on how to approach these often-overlooked areas of patient care.

Key Takeaways:

1. Ask directly about supplements, herbs, and non-prescribed products – especially in anyone with reduced kidney function or a CKD diagnosis. These are often missed unless specifically asked about.
2. Standard multivitamins are safe in CKD, but high-dose vitamin C and extra vitamin D can be harmful, especially when kidney function is already reduced.
3. Creatine, high-protein diets, and muscle mass can raise creatinine without indicating CKD. Use a urine dipstick, ACR, blood pressure, and ultrasound to assess properly.
4. Anabolic steroids and ketamine carry serious risks, including nephrotic syndrome and irreversible bladder damage. These are increasingly common but poorly understood dangers.
5. Herbal remedies are not without harm – some are directly nephrotoxic, others interact with prescribed treatments. These should be avoided in CKD, but conversations must be handled with care and cultural awareness.

This opening discussion sets the tone for the series: practical, collaborative, and focused on bridging gaps between clinical insight and everyday patient care. Supplements and herbal products are everywhere, and understanding their impact is more important than ever for improving kidney health.

References:

Creatine and kidneys: Nutrients 2023, 15, 1466. doi.org/10.3390/nu15061466

Herbal medicines and CKD; Nephrology 15 (2010) 10–17 doi:10.1111/j.1440-1797.2010.01305.x

Herbs and more: Drug stewardship for people with chronic kidney disease; towards effective, safe, and sustainable use of medications: Nat Rev Nephrol. 2024 June ; 20(6): 386–401. doi:10.1038/s41581-024-00823-3

Resource Links:
NICE GUIDELINES [NG203] chronic kidney disease: assessment and management Overview | Chronic kidney disease: assessment and management | Guidance | NICE

Northwest London CKD guidelines for primary care

The purpose of this podcast is to inform and educate health care professionals working in the primary care and community setting. The content is evidence based and consistent with NICE guidelines and North West Guidelines available at the time of publication.

The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement.

Produced by award-winning media and marketing specialist Heather Pownall of Heather's Media Hub