Imagine spitting into a $2 test tube, dozing off, and waking up to an AI-written health roadmap that flags hidden genetic typos and tells you exactly how to dodge disease. That’s the jaw-dropping future unlocked by Google’s new “Alpha Genome.” 🧬✨ In this episode, Josh and Ejaaz break down how this model reads a million DNA letters at once, pairs with CRISPR to correct single-letter glitches, and slashes genome-sequencing time from 30 days to a single night. They also reveal Microsoft’s new diagnostic AI that outperforms top physicians 4-to-1, why personalized “always-on” medicine could save $225 billion a year, and how bio-engineering is quietly becoming the next trillion-dollar wave. Hit play to see how AI is rewriting the code of life, and why living to 150 might be closer than you think.

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TIMESTAMPS

00:00 What Is Alpha Genome?
04:56 DNA For Dummies
10:34 The Next Multi Trillion Dollar Industry
11:59 Microsoft's Superhuman Doctor
16:30 How Does It Work?
22:09 Local Models on Your Phone
26:44 The Role of Humans
29:39 The Most Important Tech Of This Decade

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RESOURCES

Josh: https://x.com/Josh_Kale

Ejaaz:https://x.com/cryptopunk7213

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Not financial or tax advice. See our investment disclosures here:
https://www.bankless.com/disclosures⁠

Mark Zuckerberg just wrote the biggest talent-check in tech history - $2.5 B (about $300 M per head) to poach eight of the minds behind GPT-4 and launch “Meta Super-Intelligence Labs.” We unpack how Zuck assembled his AI Avengers, why elite researchers now cost more than NBA rosters, and what this arms race means for OpenAI, Anthropic, and the entire job market. You’ll hear the back-story on secret dinner pitches, eye-watering sign-on bonuses, and whether Meta’s next frontier model will stay open-source or slam the vault shut. Stick around for hard truths about junior dev jobs, the three skills that will keep you relevant, and a few spicy predictions for the road to super-intelligence.
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TIMESTAMPS

00:00 Start
03:42 Who Secured The Bag?
08:43 $100M Signing Bonus
12:01 Founder Mode Zuck
18:54 Is OpenAI Cooked?
27:59 Meta Going Closed Source?

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RESOURCES

David: https://x.com/trustlessstate

Josh: https://x.com/Josh_Kale

Ejaaz:https://x.com/cryptopunk7213

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Not financial or tax advice. See our investment disclosures here:
https://www.bankless.com/disclosures⁠

In this episode, we dissect the fallout from the highly-anticipated AI hardware reveal by Sam Altman and Johnny Ive. Initially celebrated, the excitement vanished when the announcement and its website disappeared overnight...

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TIMESTAMPS

00:00 Start
07:27 The Human Soul Is Missing
16:11 How To Properly Use AI
20:32 Multi Agent Breakthrough
28:58 Takeaways
42:54 AirPods With Cameras
48:02 Email Screenshots
56:05 The OpenAI Files

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RESOURCES

David: https://x.com/trustlessstate

Josh: https://x.com/Josh_Kale

Ejaaz:https://x.com/cryptopunk7213

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Not financial or tax advice. See our investment disclosures here:
https://www.bankless.com/disclosures⁠

ChatGPT has become ubiquitous, transforming how we write, code, and even think. Today we explore the potential downsides of relying too heavily on AI, examining whether its convenience might be hindering our own cognitive abilities.

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💫 LIMITLESS | SUBSCRIBE & FOLLOW
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TIMESTAMPS

00:00 Start
07:27 The Human Soul Is Missing
16:11 How To Properly Use AI
20:32 Multi Agent Breakthrough
28:58 Takeaways

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RESOURCES

David: https://x.com/trustlessstate

Josh: https://x.com/Josh_Kale

Ejaaz:https://x.com/cryptopunk7213

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Not financial or tax advice. See our investment disclosures here:
https://www.bankless.com/disclosures⁠

Blake Scholl, Founder of Boom Supersonic, shares how he's reviving commercial supersonic flight for the first time in over 50 years. From Concorde’s failure to Boom’s modern breakthroughs, Blake walks us through the engineering, regulatory, and economic obstacles that once grounded high-speed air travel and how they’re finally being overcome.

We explore the design of Boom’s Overture jet, the technology stack behind “boomless” cruise, and the company’s lean, high-stakes path from prototype to production. Blake also reflects on his journey from Amazon and Groupon to building jets, proving that audacious missions attract the best people and the boldest ideas.

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TIMESTAMPS

0:00 Intro
4:06 The Supersonic Ban Mistake
8:37 Reviving Speed: Boom’s Mission

13:09 Cracking the Business Model

15:10 The Tech Stack Behind Overture

20:51 Building at Scale

33:00 Risk and Resilience

37:58 What Makes Overture Different

45:44 Pricing Supersonic Travel
51:27 Prototype to Passenger Flight

1:04:17 Clearing Regulatory Hurdles

1:06:21 Boomless Cruise

1:13:35 Why This Could Still Fail

1:18:04 Advice

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RESOURCES

Blake Scholl

https://x.com/bscholl

Boom Supersonic

https://boomsupersonic.com/

Boomless Cruise

https://boomsupersonic.com/boomless-cruise

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Not financial or tax advice. See our investment disclosures here:

https://www.bankless.com/disclosures⁠

AI director PJ Ace walks us through how he used Google’s Veo3 to craft the first fully AI-generated commercial to air during the NBA Finals, racking up 100 million views while slashing production costs by 10×. In this conversation he breaks down his prompt stack, the viral storytelling formulas brands crave, and the coming disruption to bloated ad agencies and Hollywood workflows. Tune in to hear why hyper-personalized ads, instant character creation, and daily blockbuster-quality content are about to redefine the creator economy and how you can ride the wave.

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TIMESTAMPS

0:00 Intro
05:32 How To Guide
10:05 Is AI Cheating?
15:04 Disrupting Industries
19:25 Incoming Unlocks
22:51 Impacting Culture
29:22 Future Of TV Shows
33:30 Looking Forward

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RESOURCES

Find PJ Here:
https://x.com/PJaccetturo
https://pjace.beehiiv.com/

David: https://x.com/trustlessstate

Josh: https://x.com/Josh_Kale

Ejaaz:https://x.com/cryptopunk7213

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Not financial or tax advice. See our investment disclosures here:
https://www.bankless.com/disclosures⁠

Google’s new video model Veo 3 just let one creator crank out a $2 k, three-day commercial that ran in the NBA Finals—proof that AI can out-produce multimillion-dollar ad agencies overnight. We break down how its eight-second clips with built-in sound now enable talking characters, viral absurdity, and creator-less channels, from stormtrooper vlogs to fake pharma spots. But Veo 3’s realism also fuels deep-fake missile strikes and reality-bending stunts, so spotting the fraud is becoming a full-time job. Stick around for our chat with solo mastermind PJ Ace to hear how he pulled off the ad that fooled millions.

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TIMESTAMPS

00:00 Veo3 Is Out Of Control
10:37 Stormtroopers
20:26 How Far Does This Go?
23:53 Fake Missiles
28:59 Pro's And Cons
32:21 What To Watch

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RESOURCES

David: https://x.com/trustlessstate

Josh: https://x.com/Josh_Kale

Ejaaz:https://x.com/cryptopunk7213

Imagine answering the phone with Mark Zuckerberg on the line offering you $100 Million Dollars to come work for him 💰

That's the reality some OpenAI employees found themselves in as Meta goes on a $15B spending spree to acquire ScaleAI and some of the best talent in the world

Oh and also Meta's been publishing your AI history publicly for everyone to see... it's an interesting week for Meta
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💫 LIMITLESS | SUBSCRIBE & FOLLOW
https://limitless.bankless.com/
https://x.com/LimitlessFT
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TIMESTAMPS

0:00 $100M employee bonus?
17:58 META's AI Flop

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RESOURCES

David: https://x.com/trustlessstate

Josh: https://x.com/Josh_Kale

Ejaaz: https://x.com/cryptopunk7213

------
Not financial or tax advice. See our investment disclosures here:
https://www.bankless.com/disclosures⁠