Today, we go to a spot that may be one of the most philosophical places in the universe: the thymus, an organ that knows what is you, and what is not you. Its mood may be existential, but its role is practical — the thymus is the biological training ground where the body learns to protect itself from outside invaders (think: bacteria, coronaviruses). But this training is not the humdrum bit of science you might expect. It’s a magical shadowland with dire consequences.

Then, we’ll leave the thymus to visit a team of doctors who are using this organ that protects you as a way to protect someone… else. Their work could change everything.

Special Thanks:

One thousand thanks to Hannah Meyer, Salomé Carcy, Josh Torres, and Cold Spring Harbor Laboratory for showing us a real-life (mouse) thymus for this episode. Special thanks also go to Diane Mathis and Kate Webb.

Further reading:

Wanna do a little light reading? Here’s the immunology textbook Jenni Punt and Sharon Stranford helped write, including a whole section on that funny little thing called AIRE! Kuby Immunology

The science paper that first described what happens inside the thymus as an, “immunological self shadow”.

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And, by the way, Radiolab is looking for a remote intern! If you happen to be a creative, science-obsessed nerd who is interested in learning how to make longform radio… Apply! We would LOVE to work with you. You can find more info at wnyc.org/careers.

As our co-Hosts Lulu Miller and Latif Nasser are out this week, we are re-sharing the perfect episode to start the summer season!

This one, which first aired in 2014, tells the strange story of a small group of islands that keeps us wondering: will our most sacred natural landscapes inevitably get swallowed up by humans? How far are we willing to go to stop that from happening?

This hour is about the Galápagos archipelago, which inspired Darwin’s theory of evolution and natural selection. Nearly 200 years later, the Galápagos are undergoing rapid changes that continue to pose — and perhaps answer — critical questions about the fragility and resilience of life on Earth.

Episode Credits:Reported and produced by Tim Howard.

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about special events. Sign up (https://radiolab.org/newsletter)!

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Since the massacre that took the lives of 19 schoolchildren in Uvalde, Texas, people across the world began to ask versions of one question: why did police wait outside the door instead of protecting the kids?

It's not the first time this question has come up. Two years ago, as she watched police respond to the protests that followed the death of George Floyd, Producer B.A. Parker wondered: what are police for? With the help of our Producer Sarah Qari, she found that the United States’ Supreme Court had given this a most consequential and bewildering answer.

We decided to re-air this episode to shed light on how a case from 2005 upended our assumptions about the role police are meant to play in our lives.

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Radiolab is on YouTube! (https://zpr.io/MTSFMLXQWDkE) Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe!

A few months ago, co-Host Latif Nasser, who was otherwise healthy, saw blood in his poop. It was the start of a medical journey that made him not only question what was going on in his body, but also dig into the secret genetic story of how we became human. Curled up in a hospital bathroom, Latif tries to sort out whether his ordeal is the result of a long-lost sibling knifing him in the gut or, on the contrary, a long-forgotten kindness shared between two human-ish travelers.

Special thanks to Azra Premiji, Avir Mitra, Suzanne Lehrer, David Reich, Sriram Sankararaman, Ainara Sistiaga, Carl Zimmer, Carly Mensch, Nihal Kaur, Charlotte Hsu and Bert Gambini at the University at Buffalo Media Relations, and Latif's GI Doctor Florence Damilola Odufalu and her entire team, as well as all the staff at LA County-USC Medical Center and Keck USC hospitals who looked after Latif during his hospitalization.

Support Radiolab by becoming a member of The Lab today.

Radiolab is on YouTube! Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe!Editorial Note: This podcast was amended after initial release to change the way we refer to those afflicted by addiction.

We’re all in a tizzy here at Radiolab on account of our 20-year anniversary. And, as one does upon passing a milestone, we’ve been looking back in all kinds of ways. Two weeks ago, we went out over the airwaves, “Live on your FM dial,” a callback to our origins as a radio show. We revamped our logo and redid our website (get your Freq on, people!). More recently, Lulu's and Latif’s first stories came up in a meeting. They weren’t always the intrepid hosts of our collective journey in wonder. Soren Wheeler, our editor, thought it would be fun to highlight those firsts for you.

So here they are, baby Latif and Lulu, doing their darndest to make audio magic.

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Radiolab is on YouTube! Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe!

Back in 2002, Jad Abumrad started Radiolab as a live radio show. He DJ’d out into the ether and 20 years later we do the same. To commemorate the 20-year anniversary of the show, the Radiolab team went old school and took over WNYC Radio, live on the FM band. We answered the phones, played some wonderfully weird audio, including one piece where Kurt Vonnegut—yes, that Kurt Vonnegut—interviews the dead, took part in some games and tomfoolery, and did everything we could to have and to share in our good time.

All the world’s a stage. Or, sometimes it feels that way, especially these days. In this episode, originally aired in 2015, we push through the fourth wall, pierce the spandex-ed heart of professional wrestling, and travel 400 years into the past to unmask our obsession with authenticity and our desire to walk the line between reality and fantasy.

Thanks to Nick Hakim for the use of his song "The Light".

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Radiolab is on YouTube! Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe!

This week, we bring you two stories about little guys trying to do big big things.

First, self-proclaimed animal grinch producer Becca Bressler introduces us to perhaps the one creature that has warmed her heart: a cricket. And more specifically, a male cricket. This is a tale about a tiny Romeo insect trying to find a mate, and the ingenious lengths he’ll go to have his beckoning heard.

The hero of our story

And second, producer Annie McEwen journeys through perhaps the zaniest game of football that has ever been played. When a ragtag group of players take on the top team, will it be an underdog tale for the ages or an absolute disaster?

Special thanks to Stephen Spann and Joshua Baxter at the Doris and Harry Vice University Library at Cumberland University as well as Alison Reynolds at Georgia Tech Library. Thanks also to Rick Bell, and to Scott Larson who wrote a book all about this game called Cumberland: The True Story of the Highest Scoring Football Game in History. And finally, thanks so much to our tape syncer Ambriehl Crutchfield for her help with this episode.

If you’re still interested in learning more about this epic football game, be sure to check out this brilliant and hilarious video by sportswriter Jon Bois.

Lastly, don't forget to check out Death Sex and Money. We recommend episode titled Hard, which is deep dive into our relationship with erectile dysfunction, and the drugs developed to treat it.

Support Radiolab by becoming a member of The Lab today.

Radiolab is on YouTube! Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe!

DOWNLOAD BRAILLE READY FILE HERE (https://zpr.io/YPQjmqjec5g7)