Episodios

  • Nyrada’s drug candidate aims to protect brain and heart cells

    Nyrada’s drug candidate aims to protect brain and heart cells
    May 21 2025
    Nyrada Inc. CEO James Bonnar talked with Proactive about the company’s progress developing a first-in-class TRPC ion channel blocker. This drug candidate is currently in a Phase I clinical trial and has demonstrated both neuroprotective and cardioprotective effects in preclinical models. Bonnar explained that TRPC channels play a crucial role in cellular injury, especially in heart and brain cells, and once these cells die, they are difficult to regenerate. Bonnar said the drug is showing efficacy in three key indications: stroke, traumatic brain injury, and myocardial infarction. “This drug is shown broad activity in these three indications, and it's really proving itself to be a Swiss Army knife type drug,” he noted. Recent preclinical results highlighted strong cardioprotective effects, including an 86% preservation of myocardial tissue and anti-arrhythmic activity — a key benefit given the risk of sudden cardiac death in heart attack patients. The Phase I study involves dose escalation in healthy volunteers, and so far, safety benchmarks have been met in the first two cohorts. Nyrada plans to complete the study by Q3, paving the way for Phase II trials in patient populations. For more updates on Nyrada and other biotech innovators, visit Proactive’s YouTube channel. Don’t forget to like this video, subscribe to the channel, and turn on notifications so you never miss an update. #Nyrada #BiotechStocks #TRPCBlocker #Cardioprotection #Neuroprotection #StrokeTreatment #HeartAttackRecovery #PharmaInnovation #DrugDevelopment #ClinicalTrials #ProactiveInvestors
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    8 m
  • Inside Caledonia Mining's 2024 ESG Report & key projects

    Inside Caledonia Mining's 2024 ESG Report & key projects
    May 20 2025
    ESG Colleen Parkins takes Proactive's Stephen Gunnion through the company’s newly-released 2024 ESG report, its second to follow the Global Reporting Initiative standards. Parkins noted that this year’s report also includes an IFRS standards readiness assessment, as Caledonia benchmarks itself against the latest expectations in sustainability reporting. Key achievements highlighted include infrastructure projects in the Sitezi community near Blanket Mine — notably a high school upgrade featuring a new science and computer lab, and a Waiting Mothers Shelter at the local clinic. “The Sitezi Clinic services a 20-kilometre radius,” Parkins said, “and the Waiting Mothers Shelter lets expectant mothers stay near the clinic as they approach delivery, which is really important to me personally.” Caledonia has also made operational strides, with 20% of its power needs now met by solar energy, and 25% of its water sourced from recycling — critical during Zimbabwe’s 2024 drought. The company has aligned its tailings management with the Global Industry Standard for Tailings Management (GISTM). Looking ahead, Parkins confirmed an integrated safety, health, environment and community management system is set to go live in July 2025. Visit Proactive’s YouTube channel for more videos. Don’t forget to give this video a like, subscribe to the channel, and enable notifications for future content. #CaledoniaMining #ESGReport2024 #SustainableMining #SolarEnergy #WaterRecycling #ZimbabweMining #CommunityDevelopment #TailingsManagement #GRIStandards #IFRSReporting
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    8 m
  • Giyani Metals achieves major milestone with shipment of first high purity manganese oxide samples

    Giyani Metals achieves major milestone with shipment of first high purity manganese oxide samples
    May 20 2025
    Giyani Metals Corp CEO Charles FitzRoy talked with Proactive's Stephen Gunnion about the company’s successful shipment of its first high purity manganese oxide samples from its demonstration plant in Johannesburg. These samples have been sent to multiple potential off-takers and represent a major milestone in Giyani’s development pathway. FitzRoy noted that this is a foundational step for the company’s strategy to serve various battery chemistries. “Manganese oxide is the first step in our process,” he said, explaining that the company is now progressing towards producing manganese sulphate for additional off-takers, with samples expected to be ready in early Q3 2025. He highlighted that Giyani is the only group outside of China to have reached this demonstration scale in battery-grade manganese, calling it “the biggest de-risking event for any flow sheet.” The plant has also helped the company reduce harmful reagents, improve waste streams, and generate a valuable byproduct, all of which feed into the design of its commercial plant planned for Botswana. The Definitive Feasibility Study (DFS) timeline has been adjusted to Q1 2026 to incorporate these learnings, with commercial construction expected in 2027. FitzRoy added that increasing demand for high-manganese battery chemistries is expected from 2027/2028 onwards. For more interviews and updates, visit Proactive’s YouTube channel. Don’t forget to like this video, subscribe to our channel, and turn on notifications for future content. #GiyaniMetals #BatteryMetals #Manganese #EnergyStorage #EVbatteries #CleanEnergy #BatteryMaterials #MiningNews #GreenTech #CharlesFitzRoy #ProactiveInvestors
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    5 m
  • TNR Gold sees M&A interest as it develops royalty portfolio and delivers above market returns

    TNR Gold sees M&A interest as it develops royalty portfolio and delivers above market returns
    May 20 2025
    TNR Gold Corp executive chairman Kirill Klip talked with Proactive's Stephen Gunnion about the company's latest corporate update, strategic growth outlook, and increased M&A interest. Klip emphasized TNR Gold's focus on delivering value to shareholders by reducing dilution, generating strong returns, and controlling expenses. He highlighted growing industry interest in the company’s royalty holdings and disclosed that the board is actively reviewing M&A opportunities. “We succeeded with our marketing, and we managed to tell our story,” Klip said, noting a previous deal with Lithium Royalty Corp as a benchmark transaction. Key assets such as the Mariana Lithium Project and Los Azules Copper Project are advancing, with the Mariana Lithium Project starting production in February. Klip noted the importance of this development in potentially supporting future share buybacks. Key assets such as the Mariana Lithium Project and Los Azules Copper Project are advancing, with the Mariana Lithium Project starting production in February. Klip noted the importance of this development in potentially supporting future share buybacks. The company is also pursuing a strategic partner for the Shotgun Gold Project in Alaska, aiming to spin it out through a newly formed entity, AmeriGold. Additional updates included progress on the Batidero I and II royalty interests, tied to Lundin Mining's Josemaria Project, where a 43-101 report is expected soon. Klip reiterated TNR Gold’s intent to maximize shareholder value and affirmed management’s long-term investment in the business. For more updates like this, visit Proactive’s YouTube channel. Don’t forget to like the video, subscribe, and enable notifications to stay informed. #TNRGold #MiningNews #Lithium #Copper #Gold #MarianaProject #LosAzules #JosemariaProject #RoyaltyInvesting #MiningStocks #StrategicInvestments #MergersAndAcquisitions
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    13 m
  • Silver47 and Summa Silver merge to create premier U.S.-focused high-grade silver explorer

    Silver47 and Summa Silver merge to create premier U.S.-focused high-grade silver explorer
    May 20 2025
    Silver47 Exploration Corp CEO Gary Thompson joined Steve Darling from Proactive to announce a major development: Silver47 and Summa Silver Corp have entered into a definitive arrangement agreement to merge the two companies via a court-approved plan of arrangement. Upon completion, the combined entity will retain the name Silver47 Exploration Corp, signaling a unified brand underpinned by a strategic vision for silver exploration and development. Thompson emphasized that the merger positions the company for enhanced access to capital markets, stronger operational capabilities, and greater investor visibility. The newly combined company will boast an impressive portfolio of high-grade, silver-rich projects across top-tier U.S. mining jurisdictions, including Alaska, Nevada, and New Mexico. Collectively, the companies’ assets contain an estimated 10 million ounces silver equivalent (AgEq) in Indicated resources at an average grade of 333 g/t AgEq, and 236 million ounces AgEq in Inferred resources averaging 334 g/t AgEq. With strong geological potential, the combined company is well positioned to pursue significant resource expansion and future consolidation opportunities within the sector. In conjunction with the transaction, Summa and Silver47 have also entered into an engagement letter agreement with Research Capital Corporation and Haywood Securities to conduct a brokered private placement. The offering aims to raise up to CAD $5 million in gross proceeds, further supporting the growth and exploration plans of the merged company. Those proceeds will be put to use on the Red Mountain project in Alaska. This flagship project currently holds 168.00 million ounces of silver equivalent, and Thompson emphasized the company’s plan to expand that resource through a new drilling campaign. Thompson described the transaction as a "transformational step forward" that aligns both companies’ goals of becoming a leading silver exploration and development company in North America. #proactiveinvestors #silver47explorationcorp #tsx #exn #mining #MiningMerger #SilverExploration #RedMountainProject #SilverStocks #JuniorMining #ResourceGrowth #PEA #TSXV #MiningNews #AlaskaMining #NevadaSilver #NewMexicoMining
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    5 m
  • Trust Stamp partners with Partisia to deliver privacy-first biometric identity verification

    Trust Stamp partners with Partisia to deliver privacy-first biometric identity verification
    May 20 2025
    Trust Stamp Vice President Jonathan Patscheider joined Steve Darling from Proactive to announce a new strategic partnership with deep tech innovator Partisia, marking a major advancement in digital identity verification and cybersecurity. The two companies will jointly develop a next-generation solution for biometric holder binding—a foundational technology that enables secure and privacy-preserving identity verification across digital platforms. By merging Trust Stamp’s biometric tokenization technology with Partisia’s cutting-edge Multi-Party Computation (MPC) platform, the collaboration aims to set a new standard for how digital credentials are securely linked to an individual’s biometric data. “This partnership enables us to bring a simplified and privacy-centric identity solution to market,” said Patscheider. “With growing global demand for secure digital authentication, we are building a platform that protects individuals’ privacy without sacrificing reliability or user experience.” The combined solution removes the need for traditional biometric templates or centralized databases. Instead, it converts live biometric inputs into secure, non-reversible cryptographic representations. No raw biometric data or encryption keys are stored, ensuring the user maintains complete control over their personal information. Designed to meet the regulatory and security demands of high-stakes sectors like banking, healthcare, and government services, the Trust Stamp–Partisia solution promises to streamline onboarding, combat fraud, and help organizations maintain compliance in increasingly complex digital environments. The companies emphasize a privacy-first, decentralized model that is resilient against breaches and future-proofed for emerging global data regulations. As biometric authentication continues to gain traction, this partnership offers a powerful new approach for organizations looking to modernize their identity systems while placing user trust and privacy at the forefront. #proactiveinvestors #truststamp #nasdaq #idai #DigitalIdentity #BiometricSecurity #Partisia #BlockchainSecurity #DecentralizedID #Cybersecurity #MPC #DataPrivacy #Web3Identity #ZeroKnowledgeProofs
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    5 m
  • Fortune Minerals advances NICO project with Bismuth Circuit validation and Government support

    Fortune Minerals advances NICO project with Bismuth Circuit validation and Government support
    May 20 2025
    Fortune Minerals CEO Robin Goad joined Steve Darling from Proactive to announce that metallurgical test work validation is now essentially complete for the bismuth recovery circuits at the company’s flagship NICO cobalt-gold-bismuth-copper critical minerals project in Canada's Northwest Territories and Alberta. Goad confirmed that the Process Design Criteria for the bismuth circuits has been finalized and delivered to engineering teams for incorporation into an updated Feasibility Study. The development aligns with growing global demand for bismuth—a metal seeing renewed interest amid its use in pharmaceuticals, alloys, and green technologies—as well as soaring prices driven by China’s recent export restrictions on bismuth and other critical minerals. With 12% of the world’s known bismuth reserves, Fortune Minerals is positioned to become a key North American supplier of this increasingly strategic metal. The improved process flows have enhanced the efficiency of bismuth leaching and cementation, leading to higher metal recoveries and an expected reduction in both capital and operating costs. Additionally, the company has validated the efficient regeneration of ferric chloride lixiviant, reducing reagent costs while ensuring environmentally safe disposal of excess process water. Significantly, Fortune also announced the successful production of high-purity 4N (99.99%) bismuth ingots, confirming the commercial viability of its smelting and refining capabilities. These advancements are being supported by 17 million of non-dilutive government contribution including $6.3 million U.S. from the U.S. Department of Defense, underscoring the strategic importance of domestic critical minerals supply chains. The funding is being used to validate process improvements, complete front-end engineering and design (FEED) studies, and secure the remaining permits and authorizations for both the mine and concentrator in the NWT and the hydrometallurgical processing facility in Alberta. #proaxtiveinvestors #fortunemineralslimited #tsx #ft #otcqb #ftmdf #CriticalMinerals #NICOProject #USDoDFunding #CobaltSupply #BatteryMetals #MiningNews #ProactiveInvestors #NorthAmericanMining #MineralSecurity #ResourceInvestment
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    6 m
  • Angel Academe and SyndicateRoom back female founders with new EIS

    Angel Academe and SyndicateRoom back female founders with new EIS
    May 20 2025
    Angel Academe co-founder and CEO Sarah Turner and SyndicateRoom co-founder Tom Britton joined Stephen Gunnion in the Proactive studio following the launch of a new EIS fund focused on supporting female-led startups. Turner explained that this is the first EIS fund of its kind in the UK, aiming to correct the imbalance in venture capital allocation. “We're still at a point where women-only founded businesses are receiving less than 2% of all venture capital invested,” she said. The fund offers immediate diversification by targeting 8 to 12 companies, allowing investors to spread risk in what Turner described as a high-risk asset class. The initiative builds on Angel Academe's track record of over 100 funding rounds across 54 companies, including notable successes such as Béa Fertility, which recently secured FDA approval for its fertility device. Britton outlined his firm’s role in structuring and administering the fund. He emphasised the importance of supporting female founders and explained the tax benefits associated with EIS investments, including 30% income tax relief and capital gains exemptions. The fund is now open to retail investors via SyndicateRoom.com, with a minimum investment of £10,000. Visit Proactive’s YouTube channel for more investor interviews. Don’t forget to like this video, subscribe to our channel, and turn on notifications for future updates. #AngelAcademe #EISFund #FemaleFounders #StartupInvestment #WomenInBusiness #SyndicateRoom #VentureCapital #ImpactInvesting #BéaFertility #TaxRelief #EarlyStageInvestment #DiversifiedPortfolio #SocialImpact #CleanTech #AlternativeProteins #AngelInvesting #UKStartups #InvestmentOpportunities
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    12 m
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