In this episode of the Lupus Science and Medicine Podcast, host Dr. Anna Wolska speaks with Dr. Amerie Grammer about how genetic breakthroughs are paving the way for personalized lupus care. Researchers have identified distinct “genetic endotypes,” patterns of gene activity that explain why lupus affects people differently, including symptoms like kidney disease. These insights could one day enable more precise, targeted treatments. Tune in as we unpack what genetic endotypes are, what they reveal about lupus, and how this research brings us closer to truly individualized care for everyone living with the disease.

Read the paper published in LSM: https://doi.org/10.1136/lupus-2025-001526

In this podcast, Dr. Anna Wolska sits down with Dr. Eric Morand to discuss a groundbreaking effort to improve how lupus treatment success is measured in clinical trials. Dr. Morand explains why existing tools weren’t designed for tracking treatment response and describes a rigorous, patient-inclusive Delphi process that narrowed dozens of possible disease aspects down to eight meaningful domains. By involving patients at every step, the new measure focuses on what patients truly feel and function. Early work on defining precise assessments for each domain is underway, with practical use in trials expected by 2026, promising clearer results and faster access to new lupus therapies.

Read the paper published in LSM - https://doi.org/10.1136/lupus-2024-001484

Lupus nephritis, affecting nearly half of lupus patients, can cause severe kidney damage. Traditionally, high-dose glucocorticoids (~1 mg per kg prednisone) have been used despite significant side effects. In this episode, host Anna Wolska speaks with Dr. Amit Saxena, a rheumatologist and Associate Professor at NYU Langone Health, about his recent research on the use of glucocorticoids in treating kidney disease in lupus. His study pooled standard-of-care arms from several major clinical trials to compare the efficacy and safety of lower versus higher oral glucocorticoid doses—administered after an initial IV steroid pulse—in treating lupus nephritis.

Read the article published in LSM - https://doi.org/10.1136/lupus-2024-001351