Kennedy Schaal ⁠ CEO of ⁠Rejuve.Bio⁠ shares her inspiring journey from a childhood curiosity about aging to leading groundbreaking longevity research.

As head of the world's longest-running evolutionary biology experiment, the Methuselah fruit flies, Kennedy explains how selective breeding has dramatically extended fruit fly lifespan from just a few weeks up to seven months, revealing clear genetic signals related to longevity.

Kennedy dives into the science behind this remarkable achievement, highlighting the importance of genes like Yamanaka factors, which offer direct parallels to human aging. She underscores how evolutionary biology combined with advanced genomic analysis could unlock new ways to prevent age-related diseases.

Beyond fruit flies, Kennedy discusses the transformative potential of AI in biomedical research, detailing how artificial intelligence can uncover critical insights hidden within complex datasets. Through her collaboration with renowned AI scientist ⁠Ben Goertzel ⁠and ⁠SingularityNet⁠, Kennedy's work has already led to promising interventions for Alzheimer's disease.

While optimistic about the rapid mainstream adoption of longevity research, Kennedy also emphasizes the need for greater collaboration and openness in the scientific community.

She passionately advocates for nurturing young scientists and investing in preventive healthcare, envisioning profound societal benefits if aging is brought under greater medical control.

This conversation captures the excitement, challenges, and incredible potential of current longevity science, highlighting Kennedy Schaal’s role at the forefront of research that could reshape human healthspan.

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In this conversation, Rozalyn Anderson and Martin explore the complexities of aging, the impact of caloric restriction on longevity, and the scientific journey that led Rozalyn to her current research. They discuss the intersection of aging and disease, the role of adipose tissue, and the importance of understanding aging in the context of health and disease. The conversation highlights the significance of caloric restriction studies in both animal models and humans, emphasizing the need for a deeper understanding of the aging process. In this conversation, Rozalyn Anderson discusses the implications of caloric restriction studies, the role of GLP-1 in metabolic health, and the challenges of aging in the context of obesity. She highlights the significance of senescent cells in aging and the potential of stem cell therapies. The discussion also touches on the need for more geriatricians and the importance of investing in aging research and healthcare to improve outcomes for older adults.

Stay tuned for updates from

Longevity Summit Dublin | July 2-4 | Trinity College Dublin

Takeaways from this episode

• Aging is often perceived negatively, but it brings wisdom and experience.
• Caloric restriction can delay aging and improve survival rates.
• The study of yeast has provided significant insights into aging.
• Geroscience aims to understand the relationship between aging and diseases.
• Aging is a gradual decline in bodily systems.
• Inflammation increases with age, affecting health responses.
• Adipose tissue plays a crucial role in overall health.
• Research in monkeys can provide parallels to human aging.
• Caloric restriction has been shown to have non-permissive effects on tumor growth.
• Understanding aging can lead to better treatments for age-related diseases.
• Caloric restriction studies show promise but face compliance challenges.
• The biology of aging is complex and requires extensive research.
• GLP-1 has fascinating implications for metabolic health.
• Obesity complicates aging but is not the sole issue.
• Senescent cells contribute to inflammation and aging.
• Investing in geriatric care is crucial for an aging population.
• Longitudinal studies provide better insights into aging.
• Stem cell therapies hold potential for rejuvenating tissues.
• Aging research needs more focus on practical applications.
• Collaboration in aging research can lead to significant advancements.

Hosted on Acast. See acast.com/privacy for more information.

Hosted on Acast. See acast.com/privacy for more information.