Adrenal insufficiency is a syndrome of cortisol deficiency. A recent JAMA Review summarizes the pathophysiology, diagnosis, and treatment of adrenal insufficiency and adrenal crisis. JAMA Associate Editor David Simel, MD, MHS, discusses this and more with author Anand Vaidya, MD, MMSc.

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Interview with Anne P. Cameron, MD and Glenn T. Werneburg, MD, PhD, authors of Foley Catheter Management: A Review. Hosted by Amalia Cochran, MD.

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• Foley Catheter Management

Patients' treatment expectations may affect their treatment outcomes. Coauthor Johannes A. C. Laferton, PhD, joins JAMA Senior Editor Anne Cappola, MD, ScM, to discuss the latest article in JAMA's Communicating Medicine series, which explores how to help patients have a better experience and better outcomes with treatment.

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• Improving Patients’ Treatment Expectations

Elevated levels of lipoprotein(a) are associated with higher rates of cardiovascular events. Author Samia Mora, MD, MHS, of Brigham and Women’s Hospital and Harvard Medical School discusses measurement and interpretation of lipoprotein (a) levels with JAMA Deputy Editor Mary McGrae McDermott, MD.

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• Lipoprotein(a)

A central question in platelet transfusion is whether to follow a restrictive or liberal strategy in decisions about which patients should receive platelets. Author Ryan Metcalf, MD, University of Utah, discusses new clinical guidelines for platelet transfusion and more with JAMA Executive Editor Gregory Curfman, MD.

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Immune thrombotic thrombocytopenic purpura (iTTP) is a rare coagulopathic disorder characterized by immune-mediated thrombocytopenia and microangiopathic hemolytic anemia, that can cause life-threatening thrombosis. Coauthor Allyson M. Pishko, MD, MSCE, of the University of Pennsylvania joins JAMA Associate Editor David Simel, MD, MHS, to discuss the recent review of iTTP published in JAMA.

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• Immune Thrombotic Thrombocytopenic Purpura

The human microbiome appears to influence risk for development and progression of cancer and response to treatment. Author Jennifer Wargo, MD, University of Texas M.D. Anderson Cancer Center, discusses basic science and clinical evidence regarding the human microbiome and cancer risk with JAMA Deputy Editor Mary McGrae McDermott, MD.

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• The Microbiome and Cancer

Endometriosis, a common cause of pelvic pain, affects approximately 10% of reproductive-age females. Author Sawsan As-Sanie, MD, MPH, University of Michigan, discusses the epidemiology, pathophysiology, diagnosis, and treatment of endometriosis with JAMA Senior Editor Karen E. Lasser, MD, MPH.

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• Endometriosis