Episode Description: In this episode of GasGasGas, we a plunge into the pharmacology of oxycodone, a potent semi-synthetic opioid analgesic widely used in perioperative and chronic pain settings. Aimed at FRCA Primary candidates and anaesthetic trainees, this episode explores oxycodone's mechanism of action, pharmacokinetics, and pharmacodynamics, as well as its clinical indications, side effect profile, and relevance in anaesthesia and acute pain management.

We dissect its action on mu-opioid receptors, compare it to morphine and other opioids, and review evidence regarding oral vs intravenous formulations, metabolism via CYP450 enzymes (notably CYP3A4 and CYP2D6), and implications for renal and hepatic impairment.

Key FRCA-focused discussions include its use in multimodal analgesia, potential for respiratory depression, and issues of dependence and controlled drug legislation.

Show notes at: https://gasgasgas.uk/oxycodone-frca-primary/

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Website: www.gasgasgas.uk

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Want to have a chat? james@gasgasgas.uk

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Disclaimer / Sage Advice

All content is educational in nature, but is never intended to be acted upon independent of organised educational and training structures, and under appropriate supervision for your stage of training.

This information is not a suitable substitute for medical advice and requests for medical advice will not be acted upon.

Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed. Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.