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Professor Marc Possover reveals how our nervous system drives endometriosis pain and offers practical tools for managing symptoms through vagus nerve regulation. This groundbreaking conversation challenges traditional views of endometriosis by exploring neuropelviology – the study of pelvic nerves – and how nerve function impacts everything from pain perception to fertility.

• The pelvic nervous system controls all pelvic functions and pain signals
• Our autonomic nervous system has two branches: sympathetic (fight-or-flight) and parasympathetic (rest-and-digest)
• Endometriosis activates the sympathetic nervous system, creating widespread effects beyond the pelvis
• Vagus nerve stimulation can increase parasympathetic activity and decrease pain
• Simple techniques like ear stimulation, breath work, positive thinking, and physical activity can regulate the nervous system
• Symptoms often dismissed as "comorbidities" are actually part of one connected nervous system dysfunction
• Many patients with persistent pain after surgery may be experiencing nervous system sensitization rather than disease recurrence
• Future treatments may include neuromodulation techniques that decrease both pain and inflammation
• Understanding neuropelviology could reduce unnecessary surgeries and improve outcomes
• Both patients and doctors need education about the nervous system's role in endometriosis

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