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Genetic Testing in Depression: Promises, Pitfalls, and the Path Forward

DOI: 10.5281/zenodo.16113884

ABSTRACT

This podcast episode explores the growing field of genetic testing in depression—unpacking both its exciting promises and sobering limitations. It delves into how pharmacogenomics (PGX) and polygenic risk scores (PRS) are being marketed to personalize antidepressant treatment and predict risk for major depressive disorder (MDD). We examine the strength (and weakness) of current scientific evidence, regulatory positions from the FDA and APA, and the real-world clinical impact—or lack thereof—seen in major studies like GUIDED and PRIMECARE. The episode also tackles the ethical dilemmas of data privacy, discrimination, and informed consent, especially as these tools edge closer to mainstream psychiatry. Ultimately, the conversation calls for caution, equity, and evidence-based integration of these powerful technologies.

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OBJECTIVES

1. What is the current role of genetic factors in major depressive disorder (MDD)?

2. How do pharmacogenomic (PGX) tests aim to guide antidepressant selection and dosing?

3. What does the evidence say about the clinical utility of PGX testing, especially from studies like GUIDED and PRIMECARE?

4. How do polygenic risk scores (PRS) work, and why are they not yet ready for clinical prediction in individuals?

5. What do major regulatory and psychiatric bodies like the FDA and APA recommend regarding these tests?

6. Why is transparency in test algorithms and independent funding critical to trust and clinical adoption?

7. What ethical, legal, and social risks do genetic tests in psychiatry pose—particularly regarding stigma, insurance, and family privacy?

8. How might future advances in systems biology and multi-omics bring us closer to truly personalized psychiatric care?

Join the conversation—Have questions or thoughts about genetic testing for depression? Share them in the comments below.

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https://health.conciercare.net/news/post/10.5281.cjmg.16240973 - Funding & Ethical Disclosures

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